Mutant Sequences
Mostrando 1-12 de 3413 artigos, teses e dissertações.
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1. Comparative transcriptome profile of the leaf elongation zone of wild barley (Hordeum spontaneum) eibi1 mutant and its isogenic wild type
Abstract The naturally occurring wild barley mutant eibi1/hvabcg31 suffers from severe water loss due to the permeable leaf cuticle. Eibi1/HvABCG31 encodes a full ATP-binding cassette (ABC) transporter, HvABCG31, playing a role in cutin deposition in the elongation zone of growing barley leaves. The eibi1 allele has pleiotropic effects on the appearance of l
Genet. Mol. Biol.. Publicado em: 23/10/2017
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2. PITX2C loss-of-function mutations responsible for idiopathic atrial fibrillation
OBJECTIVE: This study aimed to identify novel PITX2c mutations responsible for idiopathic atrial fibrillation. METHODS: A cohort of 210 unrelated patients with idiopathic atrial fibrillation and 200 unrelated, ethnically matched healthy individuals used as controls were recruited. The whole coding exons and splice junctions of the PITX2c gene, which encod
Clinics. Publicado em: 2014-01
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3. Prevalence and spectrum of Nkx2.5 mutations associated with idiopathic atrial fibrillation
OBJECTIVE: The aim of this study was to evaluate the prevalence and spectrum of Nkx2.5 mutations associated with idiopathic atrial fibrillation (AF). METHODS: A cohort of 136 unrelated patients with idiopathic atrial fibrillation and 200 unrelated, ethnically matched healthy controls were enrolled. The coding exons and splice junctions of the Nkx2.5 gene
Clinics. Publicado em: 2013-06
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4. Rational design of diagnostic and vaccination strategies for tuberculosis
The development of diagnostic tests which can readily differentiate between vaccinated and tuberculosis-infected individuals is crucial for the wider utilization of bacillus Calmette-Guérin (BCG) as vaccine in humans and animals. BCG_0092 is an antigen that elicits specific delayed type hypersensitivity reactions similar in size and morphological aspects to
Brazilian Journal of Infectious Diseases. Publicado em: 2012-02
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5. Simultaneous detection of hepatitis B virus genotypes and mutations associated with resistance to lamivudine, adefovir, and telbivudine by the polymerase chain reaction-ligase detection reaction
OBJECTIVES: Detection of mutations associated to nucleos(t)ide analogs and hepatitis B virus (HBV) genotyping are essential for monitoring treatment of HBV infection. We developed a multiplex polymerase chain reaction-ligase detection reaction (PCR-LDR) assay for the rapid detection of HBV genotypes and mutations associated with lamivudine, adefovir, and tel
Brazilian Journal of Infectious Diseases. Publicado em: 2011-12
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6. Polymorphisms in promoter sequences of MDM2, p53, and p16INK4a genes in normal Japanese individuals
Research has been conducted to identify sequence polymorphisms of gene promoter regions in patients and control subjects, including normal individuals, and to determine the influence of these polymorphisms on transcriptional regulation in cells that express wild-type or mutant p53. In this study we isolated genomic DNA from whole blood of healthy Japanese in
Genetics and Molecular Biology. Publicado em: 2010
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7. Influência de KlRox1p no metabolismo fermentativo de Kluyveromyces lactis / Influence of KlRox1p on fermentative metabolism of Kluyveromyces lactis
This work is a contribution to the studies about the role of KlRox1p in fermentative metabolism of Kluyveromyces lactis. Rox1p is known in Saccharomyces cerevisiae by repressing in aerobic conditions genes that are expressed when oxygen is limited. The kinetics growth of lineages of Kluyveromyces lactis MW270-7B and its derivative mutant K. lactis MW270- 7B
Publicado em: 2009
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8. Construction of auxotrophic marker in Mycobacterium bovis BCG, knockout strain for the DPPD and proteomic study of tuberculin / Construção de marcador auxotrófico em Mycobacterium bovis BCG, de uma cepa knockout para DPPD e estudo proteômico da tuberculina
Mycobacterium bovis BCG has the potential to be an effective live vector for multivalent vaccines. However, there are two problems regarding the utilization of recombinant BCG as vaccine. The first one is that most mycobacterial cloning vectors rely on antibiotic resistance gene as selectable marker, which is used for genetic transformation. The second one i
Publicado em: 2008
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9. Characterization of the Leishmania (Leishmania) amazonensis genomic region containing the META 1 gene. / Caracterização da região genômica META 1 de Leishmania (Leishmania) amazonensis e comparação com a região ortóloga de L. (L.) major.
The characterization of coding sequences in the vicinity of the META 1 gene allowed the identification of some genes preferentially expressed in L. (L.) amazonensis infective stages. One of the identified transcripts presents a distinct pattern of expression with higher levels of mRNA in amastigotes. This gene was named LaLRR17 since it encodes a 72 kDa prot
Publicado em: 2008
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10. Regulação da expressão da fímbria CupD por sistemas de dois componentes de Pseudomonas aeruginosa Pa14 e ensaios de virulência no hospedeiro-modelo Dictyostelium discoideum / Genes involved with Pseudomonas aeruginosa PA14 pathogenicity: characterization of the promoter regions and virulence assays in the Dictyostelium discoideum host model
Pseudomonas aeruginosa is a ubiquitous gammaproteobacteria able to infect immunocompromised individuals and to cause nosocomial infections. Between two direct repeats in the PAPI-1 pathogenicity island present in strain PA14, there are two gene clusters transcribed in opposite directions. The first, composed of pvrS, pvrR, rcsC and rcsB, encodes two-componen
Publicado em: 2008
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11. Is propionate alfa-oxidation involved in the reduction of biodegradable plastic production in Burkholderia sacchari? / Alfa-oxidação de propionato está envolvida na redução da produção de plástico biodegradável em Burkholderia sacchari?
Burkholderia sacchari is a new bacterial species from brazilian soil, able to grow in sucrose, accumulating intracellular granules of polyester belonging to the polyhydroxyalkanoate family (PHA). When cultivated on sucrose, the homopolymer poly-3-hydroxybutyrate is accumulated by this bacterium, which is used as biodegradable and biocompatible plastic. When
Publicado em: 2008
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12. p53 immunostaining is correlated with reduced survival and is not correlated with gene mutations in resected pulmonary large cell carcinomas
Malignancy of pulmonary large cell carcinomas (LCC) increases from classic LCC through LCC with neuroendocrine morphology (LCCNM) to large cell neuroendocrine carcinomas (LCNEC). However, the histological classification has sometimes proved to be difficult. Because the malignancy of LCC is highly dependent on proteins with functions in the cell cycle, DNA re
Brazilian Journal of Medical and Biological Research. Publicado em: 04/06/2007