Myocardial Ischemic Preconditioning
Mostrando 1-12 de 30 artigos, teses e dissertações.
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1. Late cardiac perconditioning by phenylephrine in an isolated rat heart model is mediated by mitochondrial potassium channels
The present study was designed to investigate the effect of early and late administration of phenylephrine during ischemia against regional ischemia-reperfusion injuries in an isolated rat heart model. All animals were randomly divided into experimental groups: (I) IR (Ischemic/ reperfusion): the hearts underwent 35 min of regional ischemia followed by 60 mi
Braz. J. Pharm. Sci.. Publicado em: 24/10/2019
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2. Cardioprotective effect of preconditioning is more efficient than postconditioning in rats submitted to cardiac ischemia and reperfusion
Abstract Purpose: To investigate the cardioprotective effects of ischemic preconditioning (preIC) and postconditioning (postIC) in animal model of cardiac ischemia/reperfusion. Methods: Adult rats were submitted to protocol of cardiac ischemia/reperfusion (I/R) and randomized into three experimental groups: cardiac I/R (n=33), preCI + cardiac I/R (n=7) an
Acta Cir. Bras.. Publicado em: 2018-07
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3. Protective effects of fentanyl preconditioning on cardiomyocyte apoptosis induced by ischemia-reperfusion in rats
We aimed to study the effect of fentanyl (Fen) preconditioning on cardiomyocyte apoptosis induced by ischemia-reperfusion (I/R) in rats. A total of 120 Sprague Dawley male rats (age: 3 months) were randomly divided into: sham operation group (S group), I/R group, normal saline I/R group (NS group), and fentanyl low, middle, and high dose groups (Fen1: 2 μg/
Braz J Med Biol Res. Publicado em: 16/02/2017
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4. Long-term, regular remote ischemic preconditioning improves endothelial function in patients with coronary heart disease
Remote ischemic preconditioning (RIPre) can prevent myocardial injury. The purpose of this study was to assess the beneficial effects of long-term regular RIPre on human arteries. Forty patients scheduled for coronary artery bypass graft (CABG) surgery were assigned randomly to a RIPre group (n=20) or coronary heart disease (CHD) group (n=20). Twenty pati
Braz J Med Biol Res. Publicado em: 28/04/2015
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5. Myocardial ischemic preconditioning upregulated protein 1(Mipu1):zinc finger protein 667 - a multifunctional KRAB/C2H2 zinc finger protein
Myocardial ischemic preconditioning upregulated protein 1 (Mipu1) is a newly discovered upregulated gene produced in rats during the myocardial ischemic preconditioning process. Mipu1 cDNA contains a 1824-base pair open reading frame and encodes a 608 amino acid protein with an N-terminal Krüppel-associated box (KRAB) domain and classical zinc finger C2H2 m
Braz J Med Biol Res. Publicado em: 31/10/2014
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6. Remote preconditioning, perconditioning, and postconditioning: a comparative study of their cardio-protective properties in rat models
OBJECTIVE: Ischemia reperfusion injury is partly responsible for the high mortality associated with induced myocardial injury and the reduction in the full benefit of myocardial reperfusion. Remote ischemic preconditioning, perconditioning, and postconditioning have all been shown to be cardioprotective. However, it is still unknown which one is the most ben
Clinics. Publicado em: 2013
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7. Ação do inibidor da enzima dipeptidil peptidase 4 sobre o pré-condicionamento isquêmico em pacientes portadores de diabetes mellitus tipo 2 e doença arterial coronariana estável / Effect of dipeptidyl peptidase-4 enzyme inhibitor on ischemic preconditioning in patients with type 2 diabetes and symptomatic coronary artery disease
Ischemic preconditioning (IPC) refers to the phenomenon in which short periods of myocardial ischemia and reperfusion promote resistance to a subsequent prolonged ischemic insult. Some hypoglycemic drugs, such as glibenclamide and repaglinide, are able to inhibit this protective phenomenon probably by its effects as blockers of adenosine triphosphate-depende
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 19/10/2012
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8. A eritropoietina protege a função sistólica de corações neonatais submetidos a isquemia e reperfusão regional : trabalho experimental / Erythropoietin protects the systolic function of neonatal hearts against ischemiareperfusion injury
Background: The effect of erythropoietin (EPOT) on neonatal hearts is not well understood. The current hypothesis is that erythropoietin has protective effects against ischemia-reperfusion when administered prior to ischemia induction. Methods: Systolic and diastolic indices, as well as the Akt and extracellular regulated kinase (ERK) signaling pathways, wer
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 29/04/2012
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9. Comparação entre o teste ergométrico e a cintilografia miocárdica na avaliação do precondicionamento isquémico precoce. / The comparison between the exercise testing and myocardial scintigraphy in the assessment of early ischemic preconditiong.
O fenômeno do precondicionamento isquêmico é definido como o aumento da tolerância à isquemia e à lesão de reperfusão, induzida por curtos e sucessivos episódios de isquemia prévios a período de isquemia prolongada. A angina do aquecimento e a de pré-infarto são duas condições clínicas relacionadas ao precondicionamento. Este fenômeno aprese
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 19/04/2012
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10. Estudo dos efeitos do sevoflurano, propofol e sufentanil sobre o miocárdio na lesão de isquemia e reperfusão: estudo experimental em ratos / Study on the effects of sevoflurane, propofol and sufentanil on the myocardial ischemia and reperfusion injury: an experimental study in rats
A interrupção do fluxo sanguíneo, ou isquemia, representa um dos problemas mais importantes de doenças cardiovasculares e cerebrovasculares enfrentados pelos médicos na sua rotina. Em relação ao miocárdio muitos estudos têm sido realizados nessa área e sabe-se que os anestésicos inalatórios e os opiódes podem protege as células cardíacas contr
Publicado em: 2010
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11. Tissue expression and subcellular localization of Mipu1, a novel myocardial ischemia-related gene
Myocardial ischemic preconditioning up-regulated protein 1 (Mipu1), a novel zinc finger protein, was originally cloned using bioinformatic analysis and 5' RACE technology of rat heart after a transient myocardial ischemia/reperfusion procedure in our laboratory. In order to investigate the functions of Mipu1, the recombinant prokaryotic expression vector pQE
Brazilian Journal of Medical and Biological Research. Publicado em: 31/07/2009
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12. Escore eletrocardiográfico para avaliação de isquemia miocárdica: aplicação em testes ergométricos sequenciais para avaliação do fenômeno do aquecimento / Electrocardiographic score for myocardial ischemia evaluation: application in sequential exercise tests for warm-up phenomenon evaluation
The time to 1.0mm ST-segment depression (T-1.0mm), adopted to document the warm-up phenomenon, an expression of the ischemic preconditioning (IPC), during sequential exercise tests is considered reliable and reproductible, although with several limitations. The main goal of this study was to apply an electrocardiographic ischemic myocardium score to sequenti
Publicado em: 2009