Neuroadaptations
Mostrando 1-4 de 4 artigos, teses e dissertações.
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1. Sensibilização comportamental à cocaína e neuroadaptações na via mesocorticolímbica : interação com ontogênese, estresse e ambiente
Investigamos a influência da ontogênese, do estresse e do ambiente onde a substância psicoativa é administrada sobre a sensibilização comportamental à cocaína e o desenvolvimento de neuroadaptações. Para tanto, esse trabalho de tese foi dividido em duas partes. Na primeira, avaliamos os efeitos da administração repetida à cocaína ou exposição
Publicado em: 2009
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2. Extinction Training Regulates Neuroadaptive Responses to Withdrawal from Chronic Cocaine Self-Administration
Cocaine produces multiple neuroadaptations with chronic repeated use. Many of these neuroadaptations can be reversed or normalized by extinction training during withdrawal from chronic cocaine self-administration in rats. This article reviews our past and present studies on extinction-induced modulation of the neuroadaptive response to chronic cocaine in the
Cold Spring Harbor Laboratory Press.
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3. Extended Methamphetamine Self-Administration in Rats Results in a Selective Reduction of Dopamine Transporter Levels in the Prefrontal Cortex and Dorsal Striatum Not Accompanied by Marked Monoaminergic Depletion
Chronic abuse of methamphetamine leads to cognitive dysfunction and high rates of relapse, paralleled by significant changes of brain dopamine and serotonin neurotransmission. Previously, we found that rats with extended access to methamphetamine self-administration displayed enhanced methamphetamine-primed reinstatement of drug-seeking and cognitive deficit
The American Society for Pharmacology and Experimental Therapeutics.
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4. Sex-Specific Dissociations in Autonomic and HPA Responses to Stress and Cues in Alcohol-Dependent Patients with Cocaine Abuse
Aims: Chronic alcohol and drug dependence leads to neuroadaptations in hypothalamic–pituitary–adrenal (HPA) and sympathetic adrenal medullary (SAM) stress systems, which impact response sensitivity to stress and alcohol cue and facilitates risk of relapse. To date, gender variations in these systems have not been fully assessed in abstinent alcohol-depen
Oxford University Press.