Neuromuscular Preparations
Mostrando 1-12 de 85 artigos, teses e dissertações.
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1. Association between levobupivacaine and pancuronium. Interference in neuromuscular transmission and blockade in rats
ABSTRACT PURPOSE: To evaluate the effects of levobupivacaine on neuromuscular transmission and neuromuscular blockade produced by pancuronium in vitro. METHODS: Thirty rats were distributed into groups (n = 5) according to the drug used alone or in combination: Group I - levobupivacaine (5 µg.mL-1); Group II - pancuronium (2 µg.mL-1); Group III - pancur
Acta Cir. Bras.. Publicado em: 2016-07
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2. Presynaptic neuromuscular action of a methanolic extract from the venom of Rhinella schneideri toad
Background Rhinella schneideri, previously known as Bufo paracnemis, is a common toad in many regions of Brazil. Its venom exerts important cardiovascular effects on humans and other animals. Although this toad venom has been the subject of intense investigations, little is known about its neuromuscular activity. Methods The neurotoxicity of a methanolic
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 02/09/2014
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3. Detection and identification of huwentoxin-IV interacting proteins by biotin-avidin chemistry combined with mass spectrometry
Background : Numerous spider toxins are of interest as tools for neurophysiological research or as lead molecules for the development of pharmaceuticals and insecticides. Direct detection and identification of the interacting proteins of a spider toxin are helpful for its action-mechanism analysis and practical application. The present study employed a com
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 20/05/2014
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4. Pharmacological and partial biochemical characterization of Bmaj-9 isolated from Bothrops marajoensis snake venom
Bmaj-9, a basic PLA2 (13679.33 Da), was isolated from Bothrops marajoensis snake venom through only one chromatographic step in reversed phase HPLC on ¼-Bondapak C-18 column. The amino acid composition showed that Bmaj-9 had a high content of Lys, His, and Arg, typical of a basic PLA2. The sequence of Bmaj-9 contains 124 amino acid residues with a pI value
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 2012
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5. Estudo dos efeitos do veneno da serpente Bothrops alcatraz em preparações neuromusculares in vitro / Neuromuscular activity of Bothrops alcatraz snake venom in chick biventer cervcis preparations
Bothrops alcatraz é uma serpente do Arquipélago de Alcatrazes no litoral norte do estado de São Paulo, Brasil, recentemente descrita. Neste trabalho foram analisados os efeitos neuromusculares do veneno de B. alcatraz em preparações isoladas de biventer cervicis de pintainho (BC) e nervo frênico-diafragma de camundongo (NFD), sob estimulação elétric
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 19/08/2011
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6. Heparin and commercial bothropic antivenom against the paralyzing effect of Bothrops jararacussu snake venom
The crude venom of Bothrops jararacussu (Bjssu) is known to induce muscular paralysis in vitro. Many studies have shown that various substances, including heparin, neutralize the damage caused by snake venom. In the present study, the ability of heparin (Hep) and commercial bothropic antivenom (CBA) to neutralize neuromuscular effects of Bjssu venom, at diff
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 26/02/2010
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7. Bothrops jararacussu venom-induced neuromuscular blockade inhibited by Casearia gossypiosperma Briquet hydroalcoholic extract
The hydroalcoholic extract of Casearia gossypiosperma Briquet (Flacourtiaceae) was standardized for the first time through quality control procedures including pharmacognostic methods, fingerprint chromatograms, defined amounts of marker substances and physicochemical characteristics. The pharmacological activity of C. gossypiosperma (Cg) hydroalcoholic extr
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 2010
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8. Avaliação de neurotoxicidade autonômica e neuromuscular esquelética de extrato bruto de Phillorhiza punctata e toxina de Tityus serrulatus. / Assessment of autonomic neurotoxicity and neuromuscular skeletal Phillorhiza punctata crude extract and toxin from Tityus serrulatus.
Atualmente; tem sido intensificada a pesquisa por novas drogas em venenos e toxinas. As águas-vivas e escorpiões são organismos de relevante importância econômica; ecológica e médica. Esse trabalho mostra a investigação dos efeitos do extrato de tentáculo da água-viva Phyllorhiza punctata (PHY-N) e da toxina do escorpião Tityus serrulatus; em pre
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 13/05/2009
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9. Efeitos dos anestesicos locais na transmissão neuromuscular e no bloqueio produzido pelo rocuronio : estudo experimental / The effects of local anesthetics on the neuromuscular transmission and on the blockade produced by rocuronium : experimental study
Local anesthetics can interact with neuromuscular blockers and modify their pharmacokinetics and pharmacodynamics properties but this mechanism of interaction is very controversial. This experimental study performed in rat phrenic nerve diaphragm preparation and chick biventer cervicis muscle, had the objective to evaluate the effect of different local anest
Publicado em: 2009
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10. Efeitos farmacologicos e morfologicos do polietilenoglicol (PEG 400) em preparações neuromusculares / The influence of polyethylene glycol 400 (PEG) on the neuromuscular junction
Polyethyleneglycol has been widely used in several areas such as cosmetic, odontology and pharmaceutical (even as drugs carrier) due to its chemical properties. Thus, it is considered a bioactive molecule being its internal consumption approved by the Food and Drug Administration (FDA). The aim of this study was to analyze the pharmacological effects of PEG
Publicado em: 2009
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11. Pharmacological characterization of ASP49 PLA2 isolated from Bothrops pauloensis venom / Caracterização farmacologica de uma fosfolipase A2 ASP49 isolada do veneno de Bothrops pauloensis
Bothropic venom has several substances necessary to serpent survival, among them, one of the most widely studied are phospholipase A2 enzymes, that hydrolise sn-2 from membrane phospholipids, releasing lysophospholipids and fatty acids, which beyond playing a biological action in the lipid digestion process, also exhibit a wide variety of pharmacological eff
Publicado em: 2008
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12. Estudo das atividades neurotoxica e miotoxica de uma fosfolipase A2 basica isolada do veneno total Bothrops marajoensis / Study of neurotoxic and myotoxic activities of a phospholipase A2 isolated from the Bothrops marajoensis venom
In the present work, the neuromuscular effects of the toxin Bmaj-9 isolated from the venom of Bothrops marajoensis in the laboratory of chemistry of proteins at Unicamp were studied. This toxin was assayed in biventer cervicis preparations of little chicken, phrenic diaphragm nerve of mice and in gastrocnemius muscles of mice. In birds preparation, Bmaj-9 ca
Publicado em: 2008