Neurotoxicity Syndromes
Mostrando 1-3 de 3 artigos, teses e dissertações.
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1. A NEW MODEL OF DYSAUTONOMY INDUCED BY CHRONIC VINCRISTINE TREATMENT IN AWAKE RATS / Um novo modelo de disautonomia induzida pelo tratamento crÃnico com vincristina em ratos acordados
A vincristina à um quimioterÃpico e seu uso à limitado devido a neuropatia perifÃrica, com acometimento autonÃmico, sensitivo e motor. Sulfato de vincristina ou salina foram injetados na veia da cauda, nas doses de 50 Âg/Kg (5 doses), 100 Âg/Kg (2-5 doses) ou 150 Âg/Kg (1, 2 ou 5 doses) a cada dois dias em 144 ratos Wistar machos (200-250 g). No dia
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 12/03/2008
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2. Antiviral treatment of chronic hepatitis B virus infection: pharmacokinetics and side effects of interferon and adenine arabinoside alone and in combination.
In an uncontrolled trial, 29 patients with chronic hepatitis B virus infection were treated with 93 courses of adenine arabinoside at doses ranging from 2.5 to 15 mg/kg per day. Most patients were treated concomitantly with human leukocyte interferon. Significant, but transient, neurotoxicity was seen with adenine arabinoside therapy in 44% of all courses. M
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3. Neurotoxicity of human eosinophils
Eosinophils contain a substance that is neurotoxic when injected intracerebrally or intrathecally into laboratory animals—an effect known as the “Gordon phenomenon.” We found neurotoxic activity in eosinophils from three patients with eosinophilic syndromes by injecting cell preparations into rabbits and guinea pigs. These animals developed a syndrome