Neurotransmitter Agents
Mostrando 1-12 de 33 artigos, teses e dissertações.
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1. Doença periodontal grave em pacientes com e sem queixa de dor crônica crânio-facial: correlação dos aspectos clínicos com a análise quantitativa da substância P e do óxido nítrico do tecido gengival inflamado / Severe Periodontal Disease in patients with and without chronic complaint of craniofacial pain: correlation with clinical aspects with the quantitative analysis of substance P and nitric oxide of inflamed gingival tissue
Objetivos: Avaliar a implicação da doença periodontal (DP) avançada, e da expressão da NOS e sP dos tecidos gengivais inflamados, na intensidade de dor e na qualidade de vida de pacientes com dor crônica crânio-facial. Casuística e Métodos: foram avaliados e tratados 20 pacientes com queixas de dores crônicas crânio-faciais e DP (Grupo de Estudo),
Publicado em: 2007
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2. "Efeito modulatório da nicotina sobre a neurotransmissão em núcleos encefálicos responsáveis pelo controle cardiovascular em ratos geneticamente hipertensos e normotensos" / "Nicotine modulatory effects on neurotransmiter systems in the cardiovascular brain areas of spontaneously hypertensive and normotensive rats"
Nicotine is one of the most important agents for cardiovascular diseases in tobacco smoking. This alkaloid acts in the blood stream, but it also crosses the blood-brain-barrier and participate in the regulation of pivotal neurotransmitter systems for the blood pressure control and, eventually, for hypertension development. In this context, nicotine abuse cou
Publicado em: 2006
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3. Cholinergic and catecholaminergic receptors in the Xenopus oocyte membrane
1. Neurotransmitter-receptors in the membrane of Xenopus oocytes have been studied using electrophysiological techniques. Neurotransmitters and related agents were applied while recording either membrane potential or membrane current. The majority of ovarian oocytes used were at stages IV and V.
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4. Convergence and divergence of neurotransmitter action in human cerebral cortex.
The postsynaptic actions of acetylcholine, adenosine, gamma-aminobutyric acid, histamine, norepinephrine, and serotonin were analyzed in human cortical pyramidal cells maintained in vitro. The actions of these six putative neurotransmitters converged onto three distinct potassium currents. Application of acetylcholine, histamine, norepinephrine, or serotonin
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5. Patch-clamp and amperometric recordings from norepinephrine transporters: Channel activity and voltage-dependent uptake
Transporters for the biogenic amines dopamine, norepinephrine, epinephrine and serotonin are largely responsible for transmitter inactivation after release. They also serve as high-affinity targets for a number of clinically relevant psychoactive agents, including antidepressants, cocaine, and amphetamines. Despite their prominent role in neurotransmitter in
The National Academy of Sciences.
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6. Free cytoplasmic Ca2+ and neurotransmitter release: studies on PC12 cells and synaptosomes exposed to alpha-latrotoxin.
The relationship between the free cytoplasmic Ca2+ concentration, [Ca2+]i, and neurotransmitter release was investigated in guinea pig brain synaptosomes and the neurosecretory cell line PC12. Release was induced by alpha-latrotoxin, which acts in both Ca2+ -containing and Ca2+ -free incubation media, or by the classical depolarizing agents high K+ and verat
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7. Stimulation by Dopamine of Adenylate Cyclase in Retinal Homogenates and of Adenosine-3′:5′-Cyclic Monophosphate Formation in Intact Retina
A catecholamine-sensitive adenylate cyclase system is present in homogenates of both calf and rat retinas. Dopamine is a more potent activator of the bovine enzyme than is norepinephrine or epinephrine. Cyclic AMP concentrations in intact bovine retina are increased by dopamine, as well as by other catecholamines, and by depolarizing agents. Studies with adr
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8. Characterization of a genetically reconstituted high-affinity system for serotonin transport.
By transfecting mouse fibroblast L-M cells with human genomic DNA, we have established and identified several clonal cell lines that stably express a high-affinity serotonin (5-HT)-uptake mechanism absent in untransfected host cells. One such cell line, L-S1, possesses features of 5-[3H]HT uptake similar to those previously characterized in the central nervo
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9. Glutamatergic modulation of hyperactivity in mice lacking the dopamine transporter
In the brain, dopamine exerts an important modulatory influence over behaviors such as emotion, cognition, and affect as well as mechanisms of reward and the control of locomotion. The dopamine transporter (DAT), which reuptakes the released neurotransmitter into presynaptic terminals, is a major determinant of the intensity and duration of the dopamine
The National Academy of Sciences.
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10. Targeted enhancement of the biological activity of the antineoplastic agent, neocarzinostatin. Studies in murine neuroblastoma cells.
The development of chemotherapeutic approaches to cancer has been hampered by the toxicity of proposed agents for normal rapidly dividing cells. By using neocarzinostatin, a "pro-drug" which is activated by reduction by thiol compounds, adjunctively with 6-mercaptodopamine, a thiol-containing dopamine analogue, we have been able to enhance neocarzinostatin t
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11. Phencyclidine in low doses selectively blocks a presynaptic voltage-regulated potassium channel in rat brain.
Phencylidine (PCP) is a major drug of abuse in the United States. It produces a toxic confusional psychosis in man. We show here that nanomolar to micromolar concentrations of PCP and behaviorally active congeners selectively block voltage-regulated noninactivating (or very slowly inactivating) presynaptic K channels in the brain. The rank order of potency f
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12. Effects of serotonergic agents on neuronal nicotinic acetylcholine receptors.
In Xenopus oocytes expressing neuronal nicotinic acetylcholine receptors (nAcChoRs), made up of alpha 2 and beta 4 subunits, acetylcholine (AcCho) elicited ionic membrane currents (AcCho currents) that were modulated by serotonergic agents. Both agonists and antagonists specific for various serotonin (5-hydroxytryptamine, 5HT) receptor subtypes interacted di