Nicastrin
Mostrando 1-12 de 13 artigos, teses e dissertações.
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1. Tau, APP, NCT and BACE1 in lymphocytes through cognitively normal ageing and neuropathology
Embora a doença de Alzheimer seja um distúrbio do cérebro, uma série de alterações periféricas têm sido encontradas nesses pacientes; no entanto, pouco se sabe sobre como os genes envolvidos na fisiopatologia se expressam nas células periféricas, tais como em linfócitos durante o envelhecimento normal em comparação com o neuropatológico. Analis
An. Acad. Bras. Ciênc.. Publicado em: 2013
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2. γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2
γ-Secretase catalyzes the intramembrane proteolysis of Notch, β-amyloid precursor protein, and other substrates as part of a new signaling paradigm and as a key step in the pathogenesis of Alzheimer's disease. This unusual protease has eluded identification, though evidence suggests that the presenilin heterodimer comprises the catalytic site and that
National Academy of Sciences.
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3. Alleles at the Nicastrin locus modify presenilin 1- deficiency phenotype
Presenilin 1 (PS1), presenilin 2, and nicastrin form high molecular weight complexes that are necessary for the endoproteolysis of several type 1 transmembrane proteins, including amyloid precursor protein (APP) and the Notch receptor, by apparently similar mechanisms. The cleavage of the Notch receptor at the “S3-site” releases a C-terminal cytoplasmic
National Academy of Sciences.
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4. Activity-dependent isolation of the presenilin– γ-secretase complex reveals nicastrin and a γ substrate
Presenilin heterodimers apparently contain the active site of γ-secretase, a polytopic aspartyl protease involved in the transmembrane processing of both the Notch receptor and the amyloid-β precursor protein. Although critical to embryonic development and the pathogenesis of Alzheimer's disease, this protease is difficult to characterize, primarily becaus
The National Academy of Sciences.
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5. APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos
Early embryonic cells in Caenorhabditis elegans embryos interact through a signaling pathway closely related to the Notch signaling pathway in Drosophila and vertebrates.Components of this pathway include a ligand, receptor, the presenilin proteins, and a novel protein, APH-2, that is related to the Nicastrin protein in humans. Here we identify the aph-1 gen
The National Academy of Sciences.
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6. The Gene Encoding Nicastrin, a Major γ-Secretase Component, Modifies Risk for Familial Early-Onset Alzheimer Disease in a Dutch Population-Based Sample
Nicastrin regulates γ-secretase cleavage of the amyloid precursor protein by forming complexes with presenilins, in which most mutations causing familial early-onset Alzheimer disease (EOAD) have been found. The gene encoding nicastrin (NCSTN) maps to 1q23, a region that has been linked and associated with late-onset Alzheimer disease (LOAD) in various geno
The American Society of Human Genetics.
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7. The presenilin C-terminus is required for ER-retention, nicastrin-binding and γ-secretase activity
γ-Secretase is an intramembrane cleaving protease involved in Alzheimer's disease. γ-Secretase occurs as a high molecular weight complex composed of presenilin (PS1/2), nicastrin (NCT), anterior pharynx-defective phenotype 1 and PS enhancer 2. Little is known about the cellular mechanisms of γ-secretase assembly. Here we demonstrate that the cytoplasmic t
Nature Publishing Group.
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8. Presenilin and nicastrin regulate each other and determine amyloid β-peptide production via complex formation
Amyloid β-peptide (Aβ) is generated by the consecutive cuts of two membrane-bound proteases. β-Secretase cuts at the N terminus of the Aβ domain, whereas γ-secretase mediates the C-terminal cut. Recent evidence suggests that the presenilin (PS) proteins, PS1 and PS2, may be γ-secretases. Because PSs principally exist as high molecular weight protein co
National Academy of Sciences.
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9. Glu-333 of Nicastrin Directly Participates in γ-Secretase Activity*
γ-Secretase is a proteolytic membrane complex that processes a variety of substrates including the amyloid precursor protein and the Notch receptor. Earlier we showed that one of the components of this complex, nicastrin (NCT), functions as a receptor for γ-secretase substrates. A recent report challenged this, arguing instead that the Glu-333 residue of N
American Society for Biochemistry and Molecular Biology.
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10. High-resolution SNP mapping by denaturing HPLC
With the availability of complete genome sequences, new rapid and reliable strategies for positional cloning become possible. Single-nucleotide polymorphisms (SNPs) permit the mapping of mutations at a resolution not amenable to classical genetics. Here we describe a SNP mapping procedure that relies on resolving polymorphisms by denaturing HPLC without the
National Academy of Sciences.
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11. Nicalin and its binding partner Nomo are novel Nodal signaling antagonists
Nodals are signaling factors of the transforming growth factor-β (TGFβ) superfamily with a key role in vertebrate development. They control a variety of cell fate decisions required for the establishment of the embryonic body plan. We have identified two highly conserved transmembrane proteins, Nicalin and Nomo (Nodal modulator, previously known as pM5), a
Nature Publishing Group.
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12. Differential contribution of the three Aph1 genes to γ-secretase activity in vivo
γ-Secretase is the protease responsible for amyloid β peptide release and is needed for Notch, N-Cadherin, and possibly other signaling pathways. The protease complex consists of at least four subunits, i.e., Presenilin, Aph1, Pen2, and Nicastrin. Two different genes encode Aph1A and Aph1B in man. A duplication of Aph1B in rodents has given rise to a third
National Academy of Sciences.