Nicotinic Receptors Development
Mostrando 1-12 de 18 artigos, teses e dissertações.
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1. Influence of melatonin on the development of functional nicotinic acetylcholine receptors in cultured chick retinal cells
The influence of melatonin on the developmental pattern of functional nicotinic acetylcholine receptors was investigated in embryonic 8-day-old chick retinal cells in culture. The functional response to acetylcholine was measured in cultured retina cells by microphysiometry. The maximal functional response to acetylcholine increased 2.7 times between the 4th
Brazilian Journal of Medical and Biological Research. Publicado em: 2005-04
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2. Ectopic development of skeletal muscle induced by subcutaneous transplant of rat satellite cells
The present study analyzes the ectopic development of the rat skeletal muscle originated from transplanted satellite cells. Satellite cells (10(6) cells) obtained from hindlimb muscles of newborn female 2BAW Wistar rats were injected subcutaneously into the dorsal area of adult male rats. After 3, 7, and 14 days, the transplanted tissues (N = 4-5) were proce
Brazilian Journal of Medical and Biological Research. Publicado em: 2005-03
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3. Neurotransmitter regulation of neural development: acetylcholine and nicotinic receptors
Na última década vários sistemas de neurotransmissores têm sido relacionados ao controle do desenvolvimento do sistema nervoso. Nesta revisão, nós discutimos as evidências de que os receptores nicotínicos da acetilcolina podem apresentar uma função incomum durante o desenvolvimento, que não deve estar relacionada com seu papel na neurotransmissão
Anais da Academia Brasileira de Ciências. Publicado em: 2002-09
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4. "Nicotinic acetylcholine receptors in the chick retina in culture development: modulation by endogenous melatonin" / "Receptores nicotínicos de acetilcolina no desenvolvimento da retina de pinto em cultura: modulação por melatonina endógena"
Receptores nicotínicos da acetilcolina são encontrados na retina de pintos desde o início do desenvolvimento embrionário. As propostas desse trabalho foram caracterizar esses receptores no desenvolvimento de células de retinas embrionárias de pinto com oito dias, em cultura, e investigar se luzindole, um antagonista de receptores de melatonina, interfe
Publicado em: 2002
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5. Localization of acetylcholine receptors during synaptogenesis in retina.
Nicotinic acetylcholine receptors are synthesized in chick embryo retina before synapses appear. Most of the receptors are found associated with neurites in the inner synaptic layer of the retina; later in development the receptors appear in the outer synaptic layer. Cells dissociated from retina and cultured in vitro form aggregates and also sort out into r
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6. An Allosteric Modulator of α7 Nicotinic Receptors, N-(5-Chloro-2,4-dimethoxyphenyl)-N′-(5-methyl-3-isoxazolyl)-urea (PNU-120596), Causes Conformational Changes in the Extracellular Ligand Binding Domain Similar to Those Caused by AcetylcholineS⃞
Nicotinic acetylcholine receptors are implicated in several neuropsychiatric disorders, including nicotine addiction, Alzheimer's, schizophrenia, and depression. Therefore, they represent a critical molecular target for drug development and targeted therapeutic intervention. Understanding the molecular mechanisms by which allosteric modulators enhance a
American Society for Pharmacology and Experimental Therapeutics.
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7. Prenatal nicotine increases pulmonary α7 nicotinic receptor expression and alters fetal lung development in monkeys
It is well established that maternal smoking during pregnancy is a leading preventable cause of low birth weight and prematurity. Less appreciated is that maternal smoking during pregnancy is also associated with alterations in pulmonary function at birth and greater incidence of respiratory illnesses after birth. To determine if this is the direct result of
American Society for Clinical Investigation.
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8. Perinatal exposure to nicotine causes deficits associated with a loss of nicotinic receptor function
We investigated the role played by β2-containing neuronal nicotinic receptors [nicotinic acetylcholine receptors (nAChRs)] in mediating nicotine's side effects in the fetus and newborn. Pregnant WT and mutant mice lacking the β2 nAChR subunit were implanted with osmotic minipumps that delivered either water or a controlled dose of nicotine. Subsequently, w
National Academy of Sciences.
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9. Coordinate regulation of RNAs encoding two isoforms of the rat muscle nicotinic acetylcholine receptor beta-subunit.
The nicotinic acetylcholine receptor (nAchR) mediates communication between nerve and skeletal muscle. The properties, levels and distribution of these receptors change during development of the neuromuscular junction. These changes may be due, in part, to expression of different gene products. We are using nuclease protection experiments and cDNA cloning to
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10. Activation and Desensitization of Nicotinic α7-type Acetylcholine Receptors by Benzylidene Anabaseines and Nicotine
Nicotinic receptor activation is inextricably linked to desensitization. This duality affects our ability to develop useful therapeutics targeting nicotinic acetylcholine receptor (nAChR). Nicotine and some α7-selective experimental partial agonists produce a transient activation of α7 receptors followed by a period of prolonged residual inhibition or
American Society for Pharmacology and Experimental Therapeutics.
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11. Spontaneous muscle action potentials fail to develop without fetal-type acetylcholine receptors
In mammals, two combinations of muscle nicotinic acetylcholine receptors (AChRs) are used: α2βγδ (γ-AChR) or α2βɛδ (ɛ-AChR). After birth, γ-AChRs are replaced by ɛ-AChRs (γ/ɛ-switch). The two receptors have different conductances and open times. During perinatal period, the long open time γ-AChRs generate random myofiber action potentials from
Oxford University Press.
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12. Nicotine activates immature “silent” connections in the developing hippocampus
In the hippocampus at birth, most glutamatergic synapses are immature and functionally “silent” either because the neurotransmitter is released in insufficient amount to activate low-affinity α-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptors or because the appropriate receptor system is missing or nonfunctional. Here we show that, in the newbo
The National Academy of Sciences.