Nitrazepam
Mostrando 1-8 de 8 artigos, teses e dissertações.
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1. Tratamento de crises epilépticas de queda súbita (drop attacks) com a associação de ácido valproico, lamotrigina e um benzodiazepínico
Introdução: A epilepsia generalizada sintomática é normalmente caracterizada pela presença de crises tônicas e atônicas, muitas vezes levando o paciente a quedas súbitas. Quando isto acontece, chamamos estas crises de drop attacks. Seu tratamento é usualmente desapontador.Objetivo: Avaliar a eficácia de uma associação de três fármacos antiepil�
Publicado em: 2011
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2. Síndrome de West: evolução clínica e eletrencefalográfica de 70 pacientes e resposta ao tratamento com hormônio adrenocorticotrófico, prednisona, vigabatrina, nitrazepam e ácido valpróico
Em estudo retrospectivo avaliamos a evolução clínica e eletrencefalográfica das formas criptogênica e sintomática da síndrome de West e analisamos a eficácia do hormônio adrenocorticotrófico, vigabatrina, prednisona, ácido valpróico e nitrazepam no controle dos espasmos. Participaram do estudo 70 pacientes, acompanhados por período maior que 2 a
Arquivos de Neuro-Psiquiatria. Publicado em: 2000-09
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3. Depression of central respiratory drive by nitrazepam.
In a group of patients with chronic bronchitis, repeated night sedation with 10 mg nitrazepam produced a fall in central respiratory drive and a steady rise in arterial carbon dioxide tension. The changes produced over a five-day period were not clinically important, except in two patients who were already hypercapnic before receiving nitrazepam. The use of
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4. Polymorphic acetylation of nitrazepam.
Nitrazepam is metabolized in part by nitro-reduction to an amine followed by acetylation. This acetylation step has been shown to be under the control of the same genetic polymorphism as sulphamethazine (syn: sulphadimidine).
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5. Nitrazepam (Mogadon) in blood serum and urine and librium in urine
A method is described for the determination of nitrazepam and its reduced product in blood serum and urine. The metabolite, the reduced product, is the principal substance to be encountered in these fluids. A method is also described for the determination of librium (and the lactam) in urine.
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6. Effect of nitrazepam and flurazepam on the ventilatory response to carbon dioxide.
Ventilatory response to CO2 was measured before and after two different benzodiazepine hypnotics in both chronic bronchitics and patients without chest disease. Flurazepam, but not nitrazepam, produced a significant decrease in CO2 sensitivity, although there was no significant change in FEV1 or mixed venous PCO2. This is the first unequivocal evidence of ce
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7. Detection of superoxide generated by endothelial cells.
Superoxide and lipid free-radical generation in cultured endothelial cells treated with menadione or nitrazepam were measured using electron paramagnetic resonance spectroscopy. Superoxide was detected both intracellularly and extracellularly. Extracellular generation of superoxide and hydrogen peroxide was also measured, either by spectrophotometric measure
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8. Benzodiazepines have high-affinity binding sites and induce melanogenesis in B16/C3 melanoma cells.
We found that two markers of differentiation, tyrosinase (monophenol, dihydroxyphenylalanine:oxygen oxidoreductase, EC 1.14.18.1) activity and melanin synthesis, are induced by diazepam in B16/C3 mouse melanoma cells. We also demonstrated high-affinity binding sites for [3H]diazepam in these cells by radioreceptor assay, and we visualized binding to the cell