Nitric Oxide And Ace
Mostrando 1-12 de 12 artigos, teses e dissertações.
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1. Captopril alleviates hypertension-induced renal damage, inflammation, and NF-κB activation
Hypertensive renal damage generally occurs during the middle and late stages of hypertension, which is typically characterized by proteinuria and renal inflammation. Captopril, an angiotensin-converting enzyme (ACE) inhibitor, has been widely used for therapy of arterial hypertension and cardiovascular diseases. However, the protective effects of captopril o
Braz J Med Biol Res. Publicado em: 03/09/2018
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2. Impact of chronic administration of anabolic androgenic steroids and taurine on blood pressure in rats
Supraphysiological administration of anabolic androgenic steroids has been linked to increased blood pressure. The widely distributed amino acid taurine seems to be an effective depressor agent in drug-induced hypertension. The purpose of this study was to assess the impact of chronic high dose administration of nandrolone decanoate (DECA) and taurine on blo
Braz J Med Biol Res. Publicado em: 31/05/2016
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3. Fitoquímica e atividade vasodilatadora "in vitro de" "Mansoa hirsuta D.C.".
Mansoa hirsuta DC (Bignoniaceae) is a liana found in the Atlantic forest. There is no record of ethnomedical use for this species, although its leaves have been reported to inhibit in vitro the angiotensin-converting enzyme (ACE). The goal of the present study was to evaluate the potential antihypertensive effect of this species and to isolate the bioactive
Publicado em: 2008
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4. Alterações morfologicas e atividades e expressão de citocromos P450 no figado de ratos tratados com L-NAME / Hepatic morphological alterations and cytochrome P450 activities and expression in rats treated with L-NAME
Nitric oxide (NO), a co-product of the metabolism of L-arginine to L-citrulline by NO synthases (NOS), has an important role in regulating vascular tone, inflammatory responses, and the gene expression and enzymatic activity of various proteins, including cytochrome P450 and NOS. The chronic inhibition of NOS by Nffi-nitro-L-arginine methyl ester (L-NAME) pr
Publicado em: 2006
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5. A hipertensão arterial refrataria : caracterização fenotipica, avalliação cardiovascular morfo-funcional e correlação com polimorfismos geneticos de sistema renina-angiotensina e da sintase endotelial do oxido nitrico / Refractory hypertension : phenotypic characterization, cardiovascular morpho-functional assesssment and correlation with the renin-angiotensin-aldosterene and endothelial nitric oxide synthase gene polymorphisms
Refractory hypertension (HAR) is defined, according to the Seventh Joint National Committee (JNC VII), when the systolic arterial pressure remains above 140 mmHg and the diastolic arterial pressure above 90 mmHg even when taking three or more classes of anti-hypertensive agents including full-dose of a diuretic and the other agents at sub maximum doses with
Publicado em: 2006
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6. Nitric oxide regulates angiotensin-I converting enzyme under static conditions but not under shear stress
Mechanical forces including pressure and shear stress play an important role in vascular homeostasis via the control of the production and release of a variety of vasoactive factors. An increase in vascular shear stress is accompanied by nitric oxide (NO) release and NO synthase activation. Previously, we have demonstrated that shear stress induces angiotens
Brazilian Journal of Medical and Biological Research. Publicado em: 2003-09
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7. Interação angiotensina-(1-7) e bradicinina na microcirculação mesentérica, in vivo in situ. / Synergistic effect of angiotensin-(1-7) on bradykinin arteriolar dilation in vivo.
Interação entre angiotensina-(1-7) [Ang-(1-7)] e bradicinina (BK) foi determinada no mesentério de ratos Wistar anestesiados utilizando-se microscopia intravital. Aplicação tópica de BK e Ang-(1-7) induziram vasodilatação que foi abolida por HOE-140 e A-779, respectivamente. Ang-(1-7) (100 pmol) potencializou a vasodilatação de BK (1 pmol) mas não
Publicado em: 2000
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8. The interaction of nitric oxide (NO) with the yeast transcription factor Ace1: A model system for NO-protein thiol interactions with implications to metal metabolism
Nitric oxide (NO) was found to inhibit the copper-dependent induction of the yeast CUP1 gene. This effect is attributable to an inhibition of the copper-responsive CUP1 transcriptional activator Ace1. A mechanism is proposed whereby the metal binding thiols of Ace1 are chemically modified via NO- and O2-dependent chemistry, thereby diminishing the abil
The National Academy of Sciences.
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9. Important role of tissue angiotensin-converting enzyme activity in the pathogenesis of coronary vascular and myocardial structural changes induced by long-term blockade of nitric oxide synthesis in rats.
The long-term administration of N(omega)-nitro-L-arginine methyl ester (L-NAME), an inhibitor of nitric oxide synthesis, produces coronary vascular remodeling and myocardial hypertrophy in animals. This study used a rat model to investigate the role of angiotensin I converting enzyme (ACE) in the pathogenesis of such changes. We studied the following groups,
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10. Locus for the inducible, but not a constitutive, nitric oxide synthase cosegregates with blood pressure in the Dahl salt-sensitive rat.
Alleles of the inducible nitric oxide synthase locus (Nos2) cosegregated highly significantly (P < 0.0001) with blood pressure in an F2 population [F2(S x MNS), n = 171] derived from a cross of inbred Dahl salt-sensitive (S) rats with Milan normotensive rats (MNS). In contrast, alleles at the constitutive brain nitric oxide synthase locus (Nos1) did not cose
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11. Improvement in endothelial function by angiotensin converting enzyme inhibition in insulin-dependent diabetes mellitus.
We postulated that nitric oxide (NO)-mediated endothelial function would be improved by acute and short-term treatment with an angiotensin converting enzyme (ACE) inhibitor in patients with type I diabetes mellitus, in whom endothelial function is depressed. Nine type I diabetic patients and eight healthy subjects underwent forearm blood flow measurement usi
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12. Oxidative stress and redox signalling in cardiac hypertrophy and heart failure
Substantial evidence suggests the involvement of oxidative stress in the pathophysiology of congestive heart failure and its antecedent conditions such as cardiac hypertrophy and adverse remodelling after MI. Oxidative stress describes an imbalance between antioxidant defences and the production of reactive oxygen species (ROS), which at high levels cause ce
BMJ Group.