Nitric Oxide Synthase Type Iii
Mostrando 1-12 de 13 artigos, teses e dissertações.
-
1. Efeitos do polimorfismo T-786C do gene da óxido nítrico sintase endotelial (eNOS) e/ou da atorvastatina sobre parâmetros do metabolismo lipídico em adultos assintmáticos / Effects of the polymorphism T-786C of endothelial nitric oxide synthase (eNOS) gene and/or atorvastatin on parameters of lipid metabolism in asymptomatic adults
Nitric oxide (NO) is produced in the vascular endothelium by endothelial nitric oxide synthase (eNOS), an enzyme negatively regulated by the presence of the T-786C polymorphism, leading to endothelial dysfunction. High-density lipoproteins (HDL) have well-established anti-atherogenic functions, for example mechanisms that enhance eNOS activity. Statins are d
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 11/08/2010
-
2. Ação protetora da eritropoietina na injúria renal aguda em modelo experimental de sepse / Erithropoietin protects from acute kidney injury in a experimental model of sepsis
A sepse envolve mecanismos complexos de respostas imunológicas e inflamatórias, e o papel do NF- B é essencial. A diminuição da NO sintase endotelial (eNOS) durante a sepse contribui com a disfunção endotelial. A eritropoietina (EPO) é uma citocina protetora de diversos tecidos durante o estresse. Investigamos o papel da EPO na injúria renal aguda (
Publicado em: 2010
-
3. Autonomic function and vascular reactivity in first-degree relatives of subjects with type 2 diabetes and subjects with the 894G>T polimorphism of the endothelial nitric oxide synthase / Função autonômica e reatividade vascular em indivíduos com parentesco de diabetes tipo 2 e em portadores do polimorfismo 894G>T da óxido nítrico sintase endotelial
As doenças cardiovasculares estão entre as principais causas de mortalidade em muitos países. O sistema nervoso autônomo e a função endotelial constituem mecanismos centrais no desenvolvimento e progressão de doenças cardiovasculares. A função autonômica e a reatividade vascular podem estar alteradas em indivíduos com maior risco para doença car
Publicado em: 2009
-
4. Involvment of nitric oxide, prostaglandins and tumor necrosis factor on the development of ectopic endometrial implants (peritoneal) and its repercussions on pain and fertility in rats / Envolvimento de óxido nítrico, prostaglandinas e fator de necrose tumoral no desenvolvimento de implantes endometriais ectópicos (peritoneais) e suas repercussões sobre a dor e infertilidade em ratas
Endometriosis is a disease characterized by the presence of endometrial glands and stroma out of the uterine cavity and of the myometrium. It may cause tumor, pain (chronic pelvic pain, dyspareunia and dysmenorrhea) and infertility. Currently available evidence indicates that endometrial cells misplaced during menses into the peritoneal cavity in women with
Publicado em: 2005
-
5. Localisation of immunoreactive factor VIII, nitric oxide synthase, substance P, endothelin-1 and 5-hydroxytryptamine in human postmortem middle cerebral artery.
This pre-embedding electron-immunocytochemical study investigated the localisation of endothelial (type III) and neuronal (type I) isoforms of nitric oxide synthase, substance P, endothelin-1 and 5-hydroxytryptamine in the human middle cerebral artery taken up to 40 h postmortem. To ¿recover' from the anoxic period some of the vessels were incubated in oxyg
-
6. Nitric oxide synthase (NOS3) and contractile responsiveness to adrenergic and cholinergic agonists in the heart. Regulation of NOS3 transcription in vitro and in vivo by cyclic adenosine monophosphate in rat cardiac myocytes.
Cardiac myocytes express the nitric oxide synthase isoform originally identified in constitutive nitric oxide synthase cells (NOS3), which mediates the attenuation by muscarinic cholinergic agonists of beta-adrenergic stimulation of L-type calcium current and contractility in these cells. However, calcium current and contractility in these cells. However, th
-
7. Inducible Nitric Oxide Synthase and Nitrotyrosine Are Found in Monocytes/Macrophages and/or Astrocytes in Acute, but Not in Chronic, Multiple Sclerosis
We have examined the localization of inducible nitric oxide synthase (iNOS) and nitrotyrosine (the product of nitration of tyrosine by peroxynitrite, a highly reactive derivative of nitric oxide [NO]) in demyelinating lesions from (i) two young adult patients with acute multiple sclerosis (MS), (ii) a child with MS (consistent with diffuse sclerosis), and (i
American Society for Microbiology.
-
8. Pharmacological and immunohistochemical evidence for a functional nitric oxide synthase system in rat peritoneal eosinophils
Eosinophil migration in vivo is markedly attenuated in rats treated chronically with the NO synthase (NOS) inhibitor Nω-nitro-l-arginine methyl ester (l-NAME). In this study, we investigated the existence of a NOS system in eosinophils. Our results demonstrated that rat peritoneal eosinophils strongly express both type II (30.2 ± 11.6% of counted cells) an
The National Academy of Sciences of the USA.
-
9. Salmonella enterica Serovar Typhimurium-Dependent Regulation of Inducible Nitric Oxide Synthase Expression in Macrophages by Invasins SipB, SipC, and SipD and Effector SopE2
When Salmonella enterica invades mammalian cells, it activates signals leading to increased expression of inflammatory mediators. One such mediator is nitric oxide (NO), which is produced under control of the enzyme inducible NO synthase (iNOS). Induction of iNOS in response to Salmonella infection has been demonstrated, but the bacterial effector molecules
American Society for Microbiology.
-
10. Neither Neutrophils nor Reactive Oxygen Species Contribute to Tissue Damage during Pneumocystis Pneumonia in Mice
Neutrophils are implicated in the damage of lung tissue in many disease states, including infectious diseases and environmental insults. These effects may be due to oxidative or nonoxidative functions of the neutrophil or both. We examined the role of neutrophils in pulmonary damage during infection with the opportunistic fungal pathogen Pneumocystis sp. in
American Society for Microbiology.
-
11. Role of Cytokines and Major Histocompatibility Complex Restriction in Mouse Resistance to Infection with a Natural Recombinant Strain (Type I-III) of Toxoplasma gondii
Herein we characterized various genetic markers and the biological behavior of a natural recombinant strain of Toxoplasma gondii (P-Br). From nine genetic markers analyzed, three (B1, ROP1, and SAG1) and three (cS10-A6, GRA6, and SAG3) markers belong to parasites from the type I and type III lineages, respectively. The SAG2 and L363 loci were shown to be typ
American Society for Microbiology.
-
12. Codependent and Independent Effects of Nitric Oxide-Mediated Suppression of PhoPQ and Salmonella Pathogenicity Island 2 on Intracellular Salmonella enterica Serovar Typhimurium Survival▿
Here we show that the Salmonella enterica serovar Typhimurium PhoQ sensor kinase lessens the cytotoxicity of reactive nitrogen species (RNS) generated by inducible nitric oxide synthase (iNOS) in the innate response of mononuclear phagocytic cells. This observation is consistent with the expression patterns of PhoP-activated genes during moderate nitrosative
American Society for Microbiology (ASM).