Nitrotyrosine
Mostrando 1-12 de 86 artigos, teses e dissertações.
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1. Strong renal expression of heat shock protein 70, high mobility group box 1, inducible nitric oxide synthase, and nitrotyrosine in mice model of severe malaria
Abstract INTRODUCTION Renal damage is a consequence of severe malaria, and is generally caused by sequestration of Plasmodium falciparum -infected erythrocytes in the renal microcirculation, which leads to obstruction, hypoxia, and ischemia. This triggers high mobility group box 1 (HMGB1) to send a danger signal through toll-like receptors 2 and 4. This sig
Rev. Soc. Bras. Med. Trop.. Publicado em: 2017-08
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2. N-acetyl-cysteine inhibits liver oxidative stress markers in BALB/c mice infected with Leishmania amazonensis
BACKGROUND Leishmaniasis is a parasitosis caused by several species of the genus Leishmania. These parasites present high resistance against oxidative stress generated by inflammatory cells. OBJECTIVES To investigate oxidative stress and molecular inflammatory markers in BALB/c mice infected with L. amazonensis and the effect of antioxidant treatment on
Mem. Inst. Oswaldo Cruz. Publicado em: 2017-02
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3. Angiotensin-(1-7) relieved renal injury induced by chronic intermittent hypoxia in rats by reducing inflammation, oxidative stress and fibrosis
We aimed to study the renal injury and hypertension induced by chronic intermittent hypoxia (CIH) and the protective effects mediated by angiotensin 1-7 [Ang(1-7)]. We randomly assigned 32 male Sprague-Dawley rats (body weight 180-200 g) to normoxia control, CIH, Ang(1-7)-treated normoxia, and Ang(1-7)-treated CIH groups. Systolic blood pressure (SBP) was mo
Braz J Med Biol Res. Publicado em: 09/01/2017
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4. Sodium nitroprusside has leishmanicidal activity independent of iNOS
Abstract: INTRODUCTION: Leishmaniasis is a zoonotic disease caused by protozoa of the genus Leishmania . Cutaneous leishmaniasis is the most common form, with millions of new cases worldwide each year. Treatments are ineffective due to the toxicity of existing drugs and the resistance acquired by certain strains of the parasite. METHODS: We evaluated the
Rev. Soc. Bras. Med. Trop.. Publicado em: 2016-02
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5. Identificação de alvos protéicos com potencial diagnóstico e prognóstico em doença arterial coronária / Identification of protein targets with potential diagnostic and prognostic in coronary artery disease
Worldwide, millions of patients are treated in emergencies because they had acute-onset chest pain, but only a portion is due to coronary syndrome. In situations like this is extremely important to distinguish when the chest pain is due to myocardial ischemia, as this is high risk and initiation of treatment should be immediate. New biomarkers are needed to
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 15/06/2012
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6. Terapia laser de baixa intensidade a 808 nm reduz a resposta inflamatória e favorece a regeneração muscular
Muscle regeneration is a complex phenomenon, involving coordinated activation of several cellular responses. During this process, oxidative stress, and consequent tissue damage occur with a severity that may depend on the intensity and duration of the inflammatory response. Among the therapeutic approaches to attenuate inflammation and increase tissue repair
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 02/03/2012
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7. Hypertonic saline and reduced peroxynitrite formation in experimental pancreatitis
OBJECTIVES: In this study, we tested the hypothesis that hypertonic saline exerts anti-inflammatory effects by modulating hepatic oxidative stress in pancreatitis. INTRODUCTION: The incidence of hepatic injury is related to severe pancreatitis, and hypertonic saline reduces pancreatic injury and mortality in pancreatitis. METHODS: Wistar rats were divided in
Clinics. Publicado em: 2011
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8. Estudo do efeito farmacolÃgico da alfa, beta-amirina, uma mistura de triterpenos isolada de Protium heptaphyllum, na pancreatite aguda experimental / Pharmacological study of the effect of alfa,β-amyrin, a mixture of triterpenes isolated from Protium hepthaphyllum in acute pancreatitis experimental
Triterpenes are natural compounds with anti-inflammatory and cytoprotective effects relatively non-toxic. Acute pancreatitis, an inflammation of the pancreas, may lead to systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS), conditions that can lead the patient to death. In this study, a mixture of triterpenes isolate
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 23/11/2009
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9. Papel do macrófago na nefrotoxicidade crônica induzida pela ciclosporina A.
The aim of this study was to investigate the role of macrophage, nitric oxide pathway and oxidative stress on chronic cyclosporin (CsA) nephrotoxicity. Methods: Macrophages were depleted by clodronate liposomes (CL). Male rats on a low salt diet, were distributed in 3 groups: vehicle (VH, olive oil), CsA 7.5 mg/Kg/day (CsA, 21 days), or CsA plus CL (CsA-CL,
Publicado em: 2009
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10. O papel do receptor toll-like 4 na aterogênese em modelo experimental de aterosclerose / Role of toll-like receptor 4 in atherogenesis in an experimental model of atherosclerosis
A crucial role has been suggested for toll-like receptor 4 (TLR4) in atherosclerotic plaque formation and development. TLR4 was described primarily, as a receptor for gram-negative bacteria lipopolisacharide; later it was showed that its expression is increased in atherosclerotic plaques and patients that carries a TLR4 dysfunctional polymorphism are less su
Publicado em: 2008
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11. O cha verde (Camellia sinensis) atenua a nefropatia atraves da redução da expressão da subunidade NOX-4 da ND(P)H oxidase no diabetes mellitus experimental / Green tea (Camellia sinensis) attenuates nephropath by downregulating Nox4 NADPH oxidase in experimental diabetes mellitus
It has been suggested that green tea (GT) has beneficial properties in the treatment or prevention of human disease. The major biological mechanisms of action of GT are being attributed to its antioxidant properties. Several lines of evidence suggest that oxidative stress contributes to the pathogenesis of diabetic nephropathy. The effect of GT on diabetic n
Publicado em: 2008
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12. Oxidação e nitração de proteínas mediadas por peroxinitrito e peroxidases. Mecanismos, inibição por tempol e implicações patofisiológicas / Oxidation and nitration of proteins by peroxynitrite and peroxidases. Mechanisms, tempol inhibition and patophysiological implications
The oxidants derived from peroxynitrite and peroxidase enzymes, such as myeloperoxidase (MPO), and the lesions they promote in proteins are being extensively investigated because of their relevance in inflammatory processes. Here, the proteins RNase and lysozyme were employed as targets of oxidations/nitrations mediated by peroxynitrite and MPO/H
Publicado em: 2008