Nitroxyl
Mostrando 1-12 de 29 artigos, teses e dissertações.
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1. Dissociation of HNO and NO: leishmanicidal activity of nitrosil of ruthenium / Liberação de HNO e NO por nitrosilos de rutênio e sua atividade antileishmania
Ruthenium complexes type trans-[RuNO(NH3)4L](X)3 (X = BF4- or PF6- and L = imN, 4-pic, isn, py, pz, L- hist, nic, imC, P(OEt)3, SO32-), and [RuNO(Hedta)] were tested as antiproliferative agents against the Leishmania major parasite. The complexes where L = imN, pz, 4-pic, py, isn, and P(OEt)3 exhibited IC50pro ranging from 36 for trans-[RuNO(NH3)4imN](BF4)3
Publicado em: 2009
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2. Sobre a redução do óxido nítrico em complexos de tetraaminas de rutênio(II) / Aspects of the reduction of nitric oxide in ruthenium tetraammine complex
The electrochemical reduction behavior of the complexes trans-[Ru(NH3)4P(OEt)3NO]2+ was investigated in order to determine the possibility of these complexes to serve as nitroxyl donors (HNO/NO-). Special emphasis was given when L = P(OEt)3. Using cyclic voltammetry and differential pulse, square wave voltammetry and spectroelectrochemistry techniques was po
Publicado em: 2008
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3. Utilização do TEMPO (N-oxil-2,2,6,6-tetrametilpiperidina) na oxidação de álcoois primários e secundários
The oxidation of alcohols to obtain ketones, aldehydes or carboxylic acids is a fundamental transformation in organic synthesis and many reagents are known for these conversions. However, there is still a demand for mild and selective reagents for the oxidation of alcohols in the presence of other functional groups. As an alternative, the nitroxyl radical TE
Química Nova. Publicado em: 2004-04
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4. Nitroxyl gets to the heart of the matter
The National Academy of Sciences.
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5. A structural basis for the activity of retro-Diels–Alder catalytic antibodies: Evidence for a catalytic aromatic residue
The nitroxyl synthase catalytic antibodies 10F11, 9D9, and 27C5 catalyze the release of nitroxyl from a bicyclic pro-drug by accelerating a retro-Diels–Alder reaction. The Fabs (antigen-binding fragments) of these three catalytic antibodies were cloned and sequenced. Fab 9D9 was crystallized in the apo-form and in complex with one transition state analogue
The National Academy of Sciences.
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6. A role for nitroxyl (HNO) as an endothelium-derived relaxing and hyperpolarizing factor in resistance arteries
Blackwell Publishing Ltd.
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7. Nitroxyl anion – the universal signalling partner of endogenously produced nitric oxide?
Although it is generally assumed that the primary product of the three isoforms of NO synthase is the nitric oxide radical (NO•), growing evidence suggests that the one-electron reduced form of nitrogen monoxide, nitroxyl anion (NO−), may be a natural co-product. Thus, evidence from conduit and resistance arteries and nitrergically innervated tissues ind
Blackwell Publishing Ltd.
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8. Opposite effects of nitric oxide and nitroxyl on postischemic myocardial injury
Recent experimental evidence suggests that reactive nitrogen oxide species can contribute significantly to postischemic myocardial injury. The aim of the present study was to evaluate the role of two reactive nitrogen oxide species, nitroxyl (NO−) and nitric oxide (NO⋅), in myocardial ischemia and reperfusion injury. Rabbits were subjected to 45 min of r
The National Academy of Sciences.
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9. The reduction potential of nitric oxide (NO) and its importance to NO biochemistry
A potential of about −0.8 (±0.2) V (at 1 M versus normal hydrogen electrode) for the reduction of nitric oxide (NO) to its one-electron reduced species, nitroxyl anion (3NO−) has been determined by a combination of quantum mechanical calculations, cyclic voltammetry measurements, and chemical reduction experiments. This value is in accord with some, but
National Academy of Sciences.
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10. Identification of Nitroxyl-induced Modifications in Human Platelet Proteins Using a Novel Mass Spectrometric Detection Method*S⃞
Nitroxyl (HNO) exhibits many important pharmacological effects, including inhibition of platelet aggregation, and the HNO donor Angeli's salt has been proposed as a potential therapeutic agent in the treatment of many diseases including heart failure and alcoholism. Despite this, little is known about the mechanism of action of HNO, and its effects are rarel
American Society for Biochemistry and Molecular Biology.
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11. Nitroxyl and its anion in aqueous solutions: Spin states, protic equilibria, and reactivities toward oxygen and nitric oxide
The thermodynamic properties of aqueous nitroxyl (HNO) and its anion (NO−) have been revised to show that the ground state of NO− is triplet and that HNO in its singlet ground state has much lower acidity, pKa(1HNO/3NO−) ≈ 11.4, than previously believed. These conclusions are in accord with the observed large differences between 1HNO and 3NO− in th
The National Academy of Sciences.
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12. The decomposition of peroxynitrite to nitroxyl anion (NO−) and singlet oxygen in aqueous solution
The mechanism of decomposition of peroxynitrite (OONO−) in aqueous sodium phosphate buffer solution at neutral pH was investigated. The OONO− was synthesized by directly reacting nitric oxide with superoxide anion at pH 13. The hypothesis was explored that OONO−, after protonation at pH 7.0 to HOONO, decomposes into 1O2 and HNO according to a spin-cons
The National Academy of Sciences.