Non Genomic
Mostrando 1-12 de 794 artigos, teses e dissertações.
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1. A novel mutation in PRKAR1A gene in a patient with Carney complex presenting with pituitary macroadenoma, acromegaly, Cushing's syndrome and recurrent atrial myxoma
SUMMARY Carney complex (CNC) is a rare syndrome of multiple endocrine and non-endocrine tumors. In this paper we present a 23-year-old Iranian woman with CNC who harbored a novel mutation (c.642dupT) in PRKAR1A gene. This patient presented with pituitary macroadenoma, acromegaly, recurrent atrial myxoma, Cushing's syndrome secondary to primary pigmented nodu
Arch. Endocrinol. Metab.. Publicado em: 2021-06
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2. Identification of genomic imbalances in oral clefts
Abstract Objective This article presents a clinical and cytogenomic approach that focuses on the diagnosis of syndromic oral clefts (OCs). Methods The inclusion criteria were individuals with OC presenting four or more minor signs and no major defects (non-syndromic oral clefts [NSOCs]) as well as individuals with OC presenting at least another major defec
J. Pediatr. (Rio J.). Publicado em: 2021-06
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3. Optimized protocol to isolate high quality genomic DNA from different tissues of a palm species
RESUMO A aplicação de técnicas moleculares para lidar com questões ecológicas e evolutivas requer DNA genômico de boa qualidade e quantidade. A qualidade do DNA isolado, no entanto, pode ser influenciada pelo tipo de tecido e pela maneira como a amostra foi conservada e manipulada. Portanto, personalizar protocolos para melhorar o isolamento do DNA e a
Hoehnea. Publicado em: 22/07/2019
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4. New insights into genomic selection through population-based non-parametric prediction methods
ABSTRACT: Genome-wide selection (GWS) is based on a large number of markers widely distributed throughout the genome. Genome-wide selection provides for the estimation of the effect of each molecular marker on the phenotype, thereby allowing for the capture of all genes affecting the quantitative traits of interest. The main statistical tools applied to GWS
Sci. agric. (Piracicaba, Braz.). Publicado em: 2019-07
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5. Genomic basis of antibiotic resistance in Vibrio parahaemolyticus strain JPA1
A multi-resistant strain of Vibrio parahaemolyticus was isolated from a tropical estuary in Rio de Janeiro, Brazil. Genome sequencing was conducted to establish the molecular basis of antibiotic resistance in this organism. The genetic content of this strain revealed it to be a non-virulent lineage that nevertheless possesses several antibiotic resistance de
Mem. Inst. Oswaldo Cruz. Publicado em: 25/04/2019
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6. Determination of TNF-a Gene Polymorphisms on Skeletal Pattern in Class II Malocclusion
Resumo O desenvolvimento e crescimento ósseo é um processo contínuo, que dura toda a vida, variando muito entre os indivíduos e grande parte dessa variação pode ser modulada por fatores genéticos. O objetivo deste estudo foi avaliar a associação entre os polimorfismos no gene TNF-a e a má oclusão da classe II esquelética. Polimorfismos no gene TN
Braz. Dent. J.. Publicado em: 04/04/2019
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7. Lack of quadruple and quintuple mutant alleles associated with sulfadoxine-pyrimethamine resistance in Plasmodium vivax isolates from Brazilian endemic areas
BACKGROUND AND OBJECTIVE Brazil is responsible for a large number of Plasmodium vivax cases in America. Given the emergence of P. vivax parasites resistant to chloroquine and the effectiveness of antifolates in vivax malaria treatment together with a correlation between mutations in P. vivax dhfr and dhps genes and SP treatment failure, the point mutations
Mem. Inst. Oswaldo Cruz. Publicado em: 04/02/2019
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8. Assessment of genetic mutation frequency induced by oxidative stress in Trypanosoma cruzi
Abstract Trypanosoma cruzi is the etiological agent of Chagas disease, a public health challenge due to its morbidity and mortality rates, which affects around 6-7 million people worldwide. Symptoms, response to chemotherapy, and the course of Chagas disease are greatly influenced by T. cruzi‘s intra-specific variability. Thus, DNA mutations in this parasi
Genet. Mol. Biol.. Publicado em: 11/06/2018
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9. Genomic analysis of bifunctional Class C-Class D β-lactamases in environmental bacteria
β-lactamases, which are found in several bacterial species and environments, are the main cause of resistance to β-lactams in Gram-negative bacteria. In 2009, a protein (LRA-13) with two β-lactamase domains (one class C domain and one class D domain) was experimentally characterised, and an extended action spectrum against β-lactams consistent with two f
Mem. Inst. Oswaldo Cruz. Publicado em: 28/05/2018
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10. Trypanosoma cruzi strain TcIV infects raccoons from Illinois
BACKGROUND The northern limits of Trypanosoma cruzi across the territory of the United States remain unknown. The known vectors Triatoma sanguisuga and T. lecticularia find their northernmost limits in Illinois; yet, earlier screenings of those insects did not reveal the presence of the pathogen, which has not been reported in vectors or reservoir hosts in
Mem. Inst. Oswaldo Cruz. Publicado em: 2018-01
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11. Variability in the clinical distributions of Candida species and the emergence of azole-resistant non-Candida albicans species in public hospitals in the Midwest region of Brazil
Abstract INTRODUCTION Incidence and antifungal susceptibility of Candida spp. from two teaching public hospitals are described. METHODS The minimum inhibitory concentrations of fluconazole, voriconazole, itraconazole, and amphotericin B were determined using Clinical Laboratory Standard Institute broth microdilution and genomic differentiation using PCR.
Rev. Soc. Bras. Med. Trop.. Publicado em: 2017-12
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12. Topical application of bFGF on acid-conditioned and non-conditioned dentin: effect on cell proliferation and gene expression in cells relevant for periodontal regeneration
Abstract Periodontal regeneration is still a challenge in terms of predictability and magnitude of effect. In this study we assess the biological effects of combining chemical root conditioning and biological mediators on three relevant cell types for periodontal regeneration. Material and Methods: Bovine dentin slices were conditioned with 25% citric acid
J. Appl. Oral Sci.. Publicado em: 2017-12