Non Nmda Receptor
Mostrando 1-12 de 131 artigos, teses e dissertações.
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1. Does mismatch negativity have utility for NMDA receptor drug development in depression?
Rapid antidepressant effects associated with ketamine have shifted the landscape for the development of therapeutics to treat major depressive disorder (MDD) from a monoaminergic to glutamatergic model. Treatment with ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, may be effective, but has many non-glutamatergic targets, and clinical and logis
Brazilian Journal of Psychiatry. Publicado em: 2022
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2. Um estudo sobre a interação dos sistemas colinérgico nicotínico e dopaminérgico na persistência de memórias aversivas
Long-term memory (LTM) storage requires activation of the ventral tegmental area (VTA)- hippocampus dopaminergic loop and synthesis of brain-derived neurotrophic factor (BDNF) late after learning (Bekinschtein et al., 2007; Rossato et al., 2009). Nicotinic acetylcholine receptors (nAChR) modulate VTA function. Therefore, we analyzed the involvement of these
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 31/08/2012
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3. Increased training prevents the impairing effect of intra-amygdala infusion of the non-NMDA receptor antagonist CNQX on inhibitory avoidance expression
Intra-amygdala infusion of the non-N-methyl-D-aspartate (NMDA) receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) prior to testing impairs inhibitory avoidance retention test performance. Increased training attenuates the impairing effects of amygdala lesions and intra-amygdala infusions of CNQX. The objective of the present study was to determi
Publicado em: 2010
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4. Expressão gênica de receptores e da catalase no circuito de recompensa de camundongos sensibilizados e não sensibilizados aos efeitos estimulantes do etanol / Receptors and catalase gene expression in the reward circuit of sensitized and non-sensitized mice to the stimulant effect of ethanol
Entre as neuroadaptações que podem contribuir para o desenvolvimento de dependência do álcool está a sensibilização comportamental definida como um aumento na locomoção ou efeito estimulante após administração repetida da mesma dose de etanol (ETOH) ou outra droga. Este fenômeno ocorre devido à repetida ativação do circuito de recompensa cere
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 28/10/2009
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5. NITRIC OXIDE MODULATES THE IMPROVEMENT OF THE MEMORY INDUCED BY SPERMIDINE IN RAT / ÓXIDO NÍTRICO MODULA A MELHORA DA MEMÓRIA INDUZIDA POR ESPERMIDINA EM RATOS
The endogenous poliaminas, putrescine, spermidina and spermine are aliphatics amines that are present in high concentrations in the central nervous system (SNC). The action of the poliamines involves the modulation of several ionic channels, including the subtype of glutamatergic N-methyl-D-aspartate receptor (NMDA). The processes mediated by NMDA receptor i
Publicado em: 2006
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6. Electrophysiological evidence for the presence of NR2C subunits of N-methyl-D-aspartate receptors in rat neurons of the nucleus tractus solitarius
The nucleus tractus solitarius (NTS) plays an important role in the control of autonomic reflex functions. Glutamate, acting on N-methyl-D-aspartate (NMDA) and non-NMDA ionotropic receptors, is the major neurotransmitter in this nucleus, and the relative contribution of each receptor to signal transmission is unclear. We have examined NMDA excitatory postsyn
Brazilian Journal of Medical and Biological Research. Publicado em: 2005-01
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7. Modeling the effect of glutamate diffusion and uptake on NMDA and non-NMDA receptor saturation.
One- and two-dimensional models of glutamate diffusion, uptake, and binding in the synaptic cleft were developed to determine if the release of single vesicles of glutamate would saturate NMDA and non-NMDA receptors. Ranges of parameter values were used in the simulations to determine the conditions when saturation could occur. Single vesicles of glutamate d
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8. Purified unitary kainate/alpha-amino-3-hydroxy-5-methylisooxazole-propionate (AMPA) and kainate/AMPA/N-methyl-D-aspartate receptors with interchangeable subunits.
We have purified and characterized two vertebrate excitatory amino acid ionotropic receptors from the Xenopus central nervous system. Each is a unitary receptor (i.e., having more than one class of excitatory amino acid agonist specificity within one protein oligomer). The first is a unitary non-N-methyl-D-aspartate (non-NMDA) receptor and the second is a un
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9. Role of excitatory amino acids in the generation and transmission of respiratory drive in neonatal rat.
1. The involvement of excitatory amino acids in the generation and transmission of rhythmic respiratory drive was studied in an in vitro neonatal rat brain stem-spinal cord preparation. The subclasses of excitatory amino acid receptors studied included: (i) N-methyl-D-aspartate (NMDA) receptors, (ii) (R, S)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic
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10. Non-NMDA receptors transmit cardiopulmonary C fibre input in nucleus tractus solitarii in rats.
1. We sought first to determine whether neurones in caudomedial aspects of commissural nucleus tractus solitarii (NTS) received input from cardiopulmonary C fibre endings supplied by the pulmonary versus systemic circulation. We then examined the role of N-methyl-D-aspartate (NMDA) and non-NMDA receptors in transmitting cardiopulmonary C fibre input to such
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11. Neuromodulatory actions of dopamine in the neostriatum are dependent upon the excitatory amino acid receptor subtypes activated.
In the mammalian neostriatum, dopamine modulates neuronal responses mediated by activation of excitatory amino acid receptors. The direction of this modulation varies with the specific subtype of excitatory amino acid receptor activated. Responses evoked by iontophoretic application of glutamate (Glu) and the non-N-methyl-D-aspartate (NMDA) agonists quisqual
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12. Long-term potentiation differentially affects two components of synaptic responses in hippocampus.
We have used low magnesium concentrations and the specific antagonist D-2-amino-5-phosphonopentanoate (D-AP5) to estimate the effects of long-term potentiation (LTP) on the N-methyl-D-aspartate (NMDA) and non-NMDA receptor-mediated components of postsynaptic responses. LTP induction resulted in a considerably larger potentiation of non-NMDA as opposed to NMD