Novel Diet Induced Mice Model
Mostrando 1-7 de 7 artigos, teses e dissertações.
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1. Efeitos metabÃlicos in vivo de derivados Benzilideno-Tiazolidinadionas
Thiazolidinediones are insulin-sensitizing agents that working by binding to PPAR-γ, which leads to alteration in the expression of key regulators of lipid homeostasis, glucoregulatory and insulin resistance gene. In this study, it was evaluated the effect of treatment with novel benzylidene thiazolidinediones (BTZDs) derivatives: 5-(4-chlorobenzylidene
Publicado em: 2009
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2. Hapatic study of a diet-induced metabolic syndrome in mice : morphological profile, function and state rodox. / Estudo hepático de um modelo murino dietético para síndrome metabólica: perfil morfológico, funcional e balanço redox.
As alterações no estilo de vida das pessoas vem sendo dinamicamente observadas nas últimas décadas; destaque especial é dado aos aspectos dietéticos. Neste caso, como responsável direto por doenças crônicas, juntamente com outros aspectos do estilo de vida como sedentarismo, tabagismo, qualidade de vida. No contexto das doenças crônicas de elevada
Publicado em: 2009
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3. Esteato-hepatite não alcoólica (ENA) em camundongos obesos (ob/ob): avaliação do efeito citoprotetor do Yo Jyo Hen Shi Ko (YHK) / YO JYO HEN SHI KO, a novel Chinese herbal, prevents nonalcoholic steatohepatitis in ob/ob mice fed a high fat or methionine/choline deficient diet
Background: Oxidative stress plays a role in the pathogenesis of nonalcoholic steatohepatitis (NASH). Yo Jyo Hen Shi Ko (YHK) is a complex compound purported to reduce reactive oxygen species (ROS) by blocking the propagation of radical-induced reactions. Aim: The aim of this study was to evaluate the role of the effect of YHK in experimental NASH. Methods:
Publicado em: 2007
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4. New Zealand Ginger mouse: novel model that associates the tyrp1b pigmentation gene locus with regulation of lean body mass
The study of spontaneous mutations in mice over the last century has been fundamental to our understanding of normal physiology and mechanisms of disease. Here we studied the phenotype and genotype of a novel mouse model we have called the New Zealand Ginger (NZG/Kgm) mouse. NZG/Kgm mice are very large, rapidly growing, ginger-colored mice with pink eyes. Br
American Physiological Society.
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5. The Constitutive Androstane Receptor Is an Anti-obesity Nuclear Receptor That Improves Insulin Sensitivity*
Obesity and type 2 diabetes are related metabolic disorders of high prevalence. The constitutive androstane receptor (CAR) was initially characterized as a xenobiotic receptor regulating the responses of mammals to xenotoxicants. In this study, we have uncovered an unexpected role of CAR in preventing obesity and alleviating type 2 diabetes. Using a high fat
American Society for Biochemistry and Molecular Biology.
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6. Reduced Fat Mass in Mice Lacking Orphan Nuclear Receptor Estrogen-Related Receptor α
The estrogen-related receptor α (ERRα) is an orphan member of the superfamily of nuclear hormone receptors expressed in tissues that preferentially metabolize fatty acids. Despite the molecular characterization of ERRα and identification of target genes, determination of its physiological function has been hampered by the lack of a natural ligand. To furt
American Society for Microbiology.
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7. Biochemical and physiological function of stearoyl-CoA desaturase
A key and highly regulated enzyme that is required for the biosynthesis of monounsaturated fatty acids is stearoyl-CoA desaturase (SCD), which catalyzes the D9-cis desaturation of a range of fatty acyl-CoA substrates. The preferred substrates are palmitoyl- and stearoyl-CoA, which are converted into palmitoleoyl- and oleoyl-CoA respectively. Oleate is the mo
American Physiological Society.