Nuclear Aberrations
Mostrando 1-12 de 34 artigos, teses e dissertações.
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1. Assesment of the Genotoxic Effect of the Diazinon on Root Cells of Allium cepa (L.)
ABSTRACT Organophosphorous pesticides (OPs) posses a great potential of acute toxicity for exposed animals and men. To evaluate the toxic potential of the organophosphate diazinon on root meristematic cells of Allium cepa L., was created two groups: In group 1 (control group), was not given any chemical. In group 2 (diazinon-treatment group), different doses
Braz. arch. biol. technol.. Publicado em: 06/08/2018
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2. Análise morfológica de imagens e classificação de aberrações cromossômicass por meio de lógica fuzzy / Morphological images analysis and chromosomic aberrations classification based on Fuzzy Logic
Este trabalho desenvolve uma metodologia para a automação da análise morfológica de imagens de cromossomos humanos irradiados no reator nuclear IEA-R1 (localizado no Instituto de Pesquisas Energéticas e Nucleares, IPEN, em São Paulo, Brasil) e, portanto, sujeitos a aberrações morfológicas. Esta metodologia se propõe a auxiliar na identificação, c
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 18/10/2011
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3. Efeitos de ácido cinâmico sobre melanócitos e células derivadas de melanomas humanos: avaliação do seu potencial antitumoral e de proteção contra danos celulares causados por radiação ultravioleta. / Cinnamic acid effects on cultured human melanocytes and melanoma derived cells: evaluation of its antitumor potential and protection against cell damage caused by ultraviolet radiation.
Poucos tratamentos têm efeito sobre melanomas metastáticos, mas novas drogas vêm sendo estudadas para combater esta doença. Este trabalho avaliou efeito de ácido cinâmico (AC) em melanócitos (NGM) e células de melanoma (HT144) sobre alterações no ciclo, morte, comunicação e mobilidade celular e morfologia nuclear e investigou efeito de proteção
Publicado em: 2010
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4. Efeitos da inibição de Aurora A sobre a proliferação e fenótipo de células derivadas de hepatocarcinoma humano. / A inhibition effects in proliferation and morphology in cells derivated of Hepatocellular Carcinoma.
Hepatocarcinoma (HCC) é o mais comum tumor maligno primário do fígado. Aurora A é importante durante o ciclo celular, atuando na maturação centrossômica e sua separação, entrada em mitose, montagem de fuso bipolar, alinhamento dos cromossomos na placa metafásica e citocinese. Expressão alterada de Aurora A tem sido associada com o desenvolvimento
Publicado em: 2010
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5. Biomonitoramento genÃtico de indivÃduos expostos ocupacionalmente a pesticidas no povoado Vila Bessa, municÃpio de ConceiÃÃo do JacuÃpe, Bahia / Genetic biomonitoring of individuals occupationally exposed to pesticides in the village Vila Bassa, municipality of ConceiÃÃo do JacuÃpe, Bahia
The high consumption of pesticides in Brazil and all over the world have lead researches to relate this exposition to possible genetic and health damages in rural workers. Studies reveal that cancer is considered a genetic disease, once it results of the mutation accrual in genes involved with control of proliferation and cellular differentiation or mutation
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/11/2009
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6. Toxicity and genotoxicity of wastewater from gasoline stations
The toxicity and genotoxicity of wastewater from eight gasoline stations in Brasília, Brazil's capital city, was studied by assessing chromosomal aberrations, chromosomal malsegregation and the mitotic index in Allium cepa root cells, and the occurrence of micronucleus and nuclear abnormalities in peripheral erythrocytes of tilapia fish (Oreochromis nilotic
Genetics and Molecular Biology. Publicado em: 06/11/2009
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7. Adequacy of cytogenetic dosimetry to evaluate partial and total body irradiation / AdequaÃÃo da dosimetria citogenÃtica para avaliaÃÃo de irradiaÃÃo parcial e de corpo inteiro
The majority of human exposures to ionizing radiation involves partial human body irradiation. Thus, the use of cytogenetic dosimetry, when this aspect is not taken into account, can result in dose underestimation to the irradiated subject. In this context, this research studied methodological parameters of biodosimetry, such as cell culture time, time of Co
Publicado em: 2009
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8. Genotoxicity and mutagenicity of water contaminated with tannery effluents, as evaluated by the micronucleus test and comet assay using the fish Oreochromis niloticus and chromosome aberrations in onion root-tips
Cytotoxicity of metals is important because some metals are potential mutagens able to induce tumors in humans and experimental animals. Chromium can damage DNA in several ways, including DNA double strand breaks (DSBs) which generate chromosomal aberrations, micronucleus formation, sister chromatid exchange, formation of DNA adducts and alterations in DNA r
Genetics and Molecular Biology. Publicado em: 2006
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9. AplicaÃÃo da citogenÃtica na avaliaÃÃo da radioproteÃÃo de traumatologistas do Recife / Application of cytogenetics for evaluating radioprotection conditions of traumatologists in Recife
Among the activities involving the application of ionizing radiation in medicine, fluoroscopic procedures correspond to the major source of irradiation to doctors. Fluoroscopy consists of X-ray equipment coupled with an image intensifier. This methodology permits a real time visualization of interior of the patientâs body during a surgery. A recent study pe
Publicado em: 2006
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10. Emprego das aberraÃÃes cromossÃmicas instÃveis e micronÃcleos no biomonitoramento individual: estudo comparativo
Biodosimetry is based on the investigation of radioinduced biological effects in order to correlate them with the absorbed dose. The quantification of unstable chromosome aberrations and micronuclei, in peripheral blood lymphocytes, are two methods commonly used in biodosimetry. In this context, the aim of this research was to compare these methods in the bi
Publicado em: 2005
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11. Cytogenetic effect of Sm-153-EDTMP in peripheral lymphocytes of patients with metastaic cancer / "Efeito Citogenético do 153Sm-EDTMP em Linfócitos Periféricos de Pacientes com Câncer Metastático"
The 153Sm-EDTMP is a radiopharmaceutical used in nuclear medicine with promising results for the relief of metastatic pain. Therefore, there are few knowledge about the effects of 153Sm-EDTMP at cellular level. The present study was conducted with the aim of evaluating the cytogenetic effects of 153Sm-EDTMP in peripheral lymphocytes from patients with bone m
Publicado em: 2001
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12. Citoesqueleto e Alterações Nucleares em Celulas Tumorais: Uma Abordagem Tridimensional ao Microscópio Confocal. / Cytoskeleton and nuclear aberrations in tumor cells: a confocal microscope 3D approach.
O mecanismo de formação e origem das alterações nucleares ainda é pouco conhecido, sendo o micronúcleo a mais estudada. As células tumorais geralmente apresentam vários tipos de alterações nucleares que estariam associadas à instabilidade genética. O objetivo deste trabalho foi analisar as possíveis associações entre alterações nucleares e c
Publicado em: 2000