Nuclear Effects
Mostrando 1-12 de 1886 artigos, teses e dissertações.
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1. Clinical Significance of HSCARG for Atherosclerotic Coronary Heart Disease and Reduced ROS-Oxidative Stress in in Vivo and in Vitro Models via p47phox by NF-κB Activity
ABSTRACT Introduction: Coronary heart disease (CHD) is a dynamic process in which there are interactions between endothelial dysfunction, oxidative stress, and inflammatory responses. The aim of the present study was to investigate the function and mechanism of HSCARG in the treatment of CHD. Methods: Male apolipoprotein E/low-density lipoprotein receptor-
Brazilian Journal of Cardiovascular Surgery. Publicado em: 2022
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2. Anti-Hyperglycemic Activities, Molecular Docking and Structure-Activity Relationships (SARs) Studies of Endiandric Acids and Kingianins from Endiandra kingiana
Diabetes has become a severe chronic disease worldwide with patients significantly increasing daily. Due to the side effects of insulin and oral hypoglycaemic agents employed in diabetes treatment, scientists are working hard to develop alternative approaches from natural plants that inhibit α-amylase and α-glucosidase. Consequently, by performing a phytoc
Journal of the Brazilian Chemical Society. Publicado em: 2022
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3. Co-administration of sodium hydrosulfide and tadalafil modulates hypoxia and oxidative stress on bladder dysfunction in a rat model of bladder outlet obstruction
ABSTRACT Purpose: This study aimed to assess the possible healing effect of combination treatment with a hydrogen sulfide (H2S) donor, sodium hydrosulfide (NaHS) plus tadalafil on partial bladder outlet obstruction (PBOO)-induced bladder dysfunction. Materials and Methods: A total of 75 male Sprague-Dawley rats aged 10-wk and 300-350g were divided into fiv
International braz j urol. Publicado em: 2022
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4. Optimization and Study of the Response Surface of Properties for the Synthesis of ZSM-5 Zeolites with Hierarchical Pore Structure Obtained by Desilication
Hierarchical ZSM-5 zeolites were prepared by alkali treatment (desilication) at two temperatures, two reaction times, and two NaOH concentrations. A 23 factorial design was used to study the effect of these variables on the crystallinity, microporosity, and mesoporosity of the zeolite due to the desilication treatment. The factorial design analysis showed th
J. Braz. Chem. Soc.. Publicado em: 2021-06
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5. Synthesis, in silico Study and Antileishmanial Evaluation of New Selenides Derived from 7-Chloro-quinoline and N-Phenylacetamides
This study describes a virtual screening performed for two series of selenides (28 compounds), derived from N-phenylacetamides chlorides and 7-chloro-quinoline, to determine their potential for leishmanicidal activity against Leishmania amazonensis and Leishmania donovani. Seven compounds were predicted as potential leishmanicides; therefore, they were synth
J. Braz. Chem. Soc.. Publicado em: 2021-04
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6. EVALUATION OF THE CHEMICAL COMPOSITION AND STRUCTURE OF ASPHALTENES FROM THREE OFFSHORE BRAZILIAN BIODEGRADED HEAVY OILS
Asphaltenes fractions were extracted and purified from three heavy Brazilian oils. Their mass compositions of C, H, N, Ni and V were obtained from elemental analysis and S and O atomic percentages from EDS. The H/C ratios showed high degree of unsaturation, while the O atomic percentages indicated more pronounced biodegradation effects on two samples. Quanti
Quím. Nova. Publicado em: 2021-04
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7. Multifunctionality of βCD/Ofloxacin and HPβCD/Ofloxacin Complexes: Improvement of the Antimicrobial Activity and Apoptosis Induction on Lung Adenocarcinoma A549 Cells
The ofloxacin (OFLOX) is a second-generation synthetic antibiotic that can be classified as a multifunctional drug, but is a poorly soluble drug, which influences its efficiency. The inclusion complexes of OFLOX with β-cyclodextrin (βCD) or hydroxypropyl-β-cyclodextrin (HPβCD) can improve the chemical characteristics of the drug; however, studies showing
J. Braz. Chem. Soc.. Publicado em: 2020-12
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8. Synthesis, Characterization, Absorption and Fastness Properties of Novel Monoazo Dyes Derived from 1-Phenyl-3-amino-4-(2-thiazolilazo)pyrazol-5-one
Monosubstitute thiazolyl amines were diazotized in acetic acid, coupled to 1-phenyl-3-aminopyrazol-5-one (1a-1c) and acetylated to obtain the 2a-2c dyes. The dyes were characterized by elemental analysis and spectroscopic (Fourier transform infrared (FTIR), nuclear magnetic resonance (NMR), ultraviolet (UV)) methods. The effects on the visible absorption spe
J. Braz. Chem. Soc.. Publicado em: 2020-09
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9. Combined Analytical Py-GC/MS, SEM, FTIR and 13C NMR for Investigating the Removal of Trace Metals from Aqueous Solutions by Biochar
In this study, the efficiency of biochar (BC) produced from sugarcane bagasse at different pyrolysis temperatures (300, 400, 500 and 600 ºC) for simultaneous removal of CdII, PbII, CuII, CrIII, NiII and ZnII ions from aqueous solutions was assessed. All BC were characterized using scanning electron microscopy (SEM), Fourier transform infrared (FTIR), 13C nu
J. Braz. Chem. Soc.. Publicado em: 2020-07
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10. Synthesis, Characterization and in vitro, in vivo and in silico Anti-Inflammatory Studies of the Novel Hybrid Based on Ibuprofen and 3-Hydroxy-Copalic Acid Isolated from Copaiba Oil (Copaifera multijuga)
A novel anti-inflammatory hybrid 3-ibuprofenyl-copalic acid (3-IbuCA) was synthesized from 3-hydroxy-copalic acid isolated from Amazonian copaiba oil (Copaifera multijuga Hayne), and the anti-inflammatory ibuprofen. After full characterization, several assays to verify its anti-inflammatory effects were performed in vitro, in vivo and in silico (molecular do
J. Braz. Chem. Soc.. Publicado em: 2020-07
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11. Antioxidant-mediated protective role of Hericium erinaceus (Bull.: Fr.) Pers. against oxidative damage in fibroblasts from Friedreich’s ataxia patient
Abstract Friedreich’s ataxia (FRDA) is a progressive neuromuscular disorder caused by substantial decrease of mitochondrial protein frataxin responsible for biogenesis of iron-sulphur clusters and protection from oxidative damage. In this study, we investigated the antioxidant activities of a standardized aqueous extract from fruiting bodies of Hericium er
Food Sci. Technol. Publicado em: 2020-06
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12. Synthesis of Glycerol-Derived 4-Alkyl-Substituted 1,2,3-Triazoles and Evaluation of Their Fungicidal, Phytotoxic, and Antiproliferative Activities
Herein, the synthesis of nine novel glycerol-derived 4-alkyl-substituted 1,2,3-triazoles, using the CuI-catalyzed alkyne-azide cycloaddition reaction as the key step, is reported. The triazoles were characterized by infrared and nuclear magnetic resonance (NMR 1H and 13C) spectroscopy and mass spectrometry. The nine prepared compounds were evaluated with reg
J. Braz. Chem. Soc.. Publicado em: 2020-04