Nucleophilic Substitution
Mostrando 1-12 de 31 artigos, teses e dissertações.
-
1. Synthesis and Evaluation of Antibacterial Activity of 1,2,3-Triazole and Ether Derivatives of Paeonol
Multi-drug-resistant bacteria (MDR) are the cause of different infections and diseases that have affected humanity for a long time, and have been an emerging global health problem that has led to increased morbidity and mortality. The growing emergence of MDR bacteria has underlined the need for development and discovery of new antibacterial compounds. In th
Journal of the Brazilian Chemical Society. Publicado em: 2023
-
2. New Diesters Derived from Piperine: in silico Study and Evaluation of Their Antimicrobial Potential
Piperine, previously extracted from black pepper (Piper nigrum L.), was used as a precursor for the synthesis of twelve new diester derivatives. The final products were obtained through the bimolecular nucleophilic substitution reaction (SN2) of the alkyl 2-chloroacetates and the salt of piperic acid, obtained from the basic hydrolysis of piperine. The compo
J. Braz. Chem. Soc.. Publicado em: 2020-08
-
3. Identifying New Isatin Derivatives with GSK-3β Inhibition Capacity through Molecular Docking and Bioassays
The semi-synthesis of 11 isatin derivatives was achieved through bimolecular nucleophilic substitution and click chemistry. Seven new compounds were obtained. All chemical structures were determined by infrared spectroscopy (IR), nuclear magnetic resonance spectrometry (NMR) and high-resolution mass spectrometry (HRMS) data. These derivatives were evaluated
J. Braz. Chem. Soc.. Publicado em: 2020-03
-
4. Synthesis of New Conjugates 1H-Pyrazolo[3,4-b]pyridine-phosphoramidate and Evaluation against Leishmania amazonensis
In this research three series of substituted 1H-pyrazolo[3,4-b]pyridine phosphoramidates were synthesized and characterized by infrared, 1H, 13C, and 31P nuclear magnetic resonance (NMR) spectroscopy and high-resolution mass spectrometry. The products were obtained in good yields (67-83%) under mild conditions by nucleophilic aromatic substitution reaction o
J. Braz. Chem. Soc.. Publicado em: 2018-01
-
5. How Accurate is the SMD Model for Predicting Free Energy Barriers for Nucleophilic Substitution Reactions in Polar Protic and Dipolar Aprotic Solvents?
In the past seven years, the SMD (Solvent Model Density) method has been widely used by computational chemists. Thus, assessment on the reliability of this model for modeling chemical process in solution is worthwhile. In this report, it was investigated six anion-molecule nucleophilic substitution reactions in methanol and dipolar aprotic solvents. Geometry
J. Braz. Chem. Soc.. Publicado em: 2016-11
-
6. UM MÉTODO EFICIENTE PARA A OBTENÇÃO DE DERIVADOS DE 1-ALQUILAMINO-2,4-DINITROBENZENO E A REDUÇÃO REGIOSSELETIVA PARA A OBTENÇÃO DE DERIVADOS DE 1-ALQUILAMINO-2-AMINO-4-NITROBENZENO
Both primary and secondary amines react with 2,4-dinitrochlorobenzene to give derivatives of 1-alkylamino-2,4-dinitrobenzene. These compounds are important intermediates for the synthesis of a diverse range of products. The methodology reported in the present study involves either the room temperature reaction or heating at 70 °C in ethanol in the presence
Quím. Nova. Publicado em: 2016-01
-
7. Ab initio and CVTST investigation of the gas phase nucleophilic substitution CH3Cl + OH- → CH3OH + Cl-
Neste trabalho, o estudo teórico da reação de substituição nucleofílica de segunda ordem em fase gasosa, CH3Cl + OH-→ CH3OH + Cl-, é apresentado visando a descrição do caminho de reação e o cálculo de coeficientes de velocidade pelo método do estado de transição variacional canônico (CVTST). Cálculos teóricos foram conduzidos em nível MP
J. Braz. Chem. Soc.. Publicado em: 2014-02
-
8. Obtenção de biodiesel por transesterificação em dois estágios e sua caracterização por cromatografia gasosa: óleos e gorduras em laboratório de química orgânica
Methanolic transesterification of oils and fats was carried out in a two steps procedure, under basic and acidic catalysis. Palm, soybean, canola, corn, rice, grapeseed, sunflower, peanut, pequi and olive oils, besides tallow and lard were used as feedstock. Specific gravity, relative viscosity, thin layer chromatography and gas chromatography were used to c
Quím. Nova. Publicado em: 2013
-
9. 2-Bromo-1,4-naphthoquinone: a potentially improved substitute of menadione in Apatone™ therapy
Apatone™, a combination of menadione (2-methyl-1,4-naphthoquinone, VK3) and ascorbic acid (vitamin C, VC) is a new strategy for cancer treatment. Part of its effect on tumor cells is related to the cellular pro-oxidative imbalance provoked by the generation of hydrogen peroxide (H2O2) through naphthoquinone redox cycling. In this study, we attempted to fin
Brazilian Journal of Medical and Biological Research. Publicado em: 2012-08
-
10. Síntese de novos derivados de 1-(7-cloro-4- Quinolinil)tiossemicarbazidas e Semicarbazidas como potencias agentes Antibacterianos e antiparasitários
This work, entitled Synthesis of novel derivatives of 1-(7-chloro-4- quinolinyl)thiosemicarbazides and semicarbazides as potencial antibacterial and antiparasitic agents describes the synthesis of new derivatives of 1-(7-chloro-4- quinolinyl)thiosemicarbazides and semicarbazides, N-1-substituted pyridine derivatives were also prepared and their evaluation as
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 18/07/2011
-
11. ESTUDO DO COMPORTAMENTO QUÍMICO DE HETEROCICLOS TRIFLUORMETIL SUBSTITUÍDOS EM REAÇÕES COM DAST / STUDY OF THE CHEMICAL BEHAVIOR OF TRIFLUOROMETHYL SUBSTITUTED HETEROCYCLES IN REACTIONS WITH DAST
This work describes the study of the chemical behavior of trifluoromethyl substituted heterocycles as 1H-pyrazoles, 2-pyrazolines, 2H-cromenones and isoxazolines in reactions with DAST, with the aim of evaluating possible reactions in the oxygenated sites, aiming mainly the insertion of fluorine atoms in these molecules. Trifluoromethylated heterocycle precu
Publicado em: 2011
-
12. Síntese, caracterização e polimerização de bis(metacrilamida)s
The aim of this study was the synthesis, characterization and investigation of kinetic behavior of photo- and thermal polymerization of 4,4-diphenylmethane-bis(methacrylamide) (BisFenil), N,N¿,hexamethylene-bis(methacrylamide) (BisHexa), N,N¿-decamethylene-bis(methacrylamide) (BisDeca) and N,N¿-dodecamethylene-bis(methacrylamide) (BisDodeca). Methacrylate
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2011