Ob Ob Db Db
Mostrando 1-12 de 31 artigos, teses e dissertações.
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1. Efeito da restrição protéica materna durante a lactação sobre a resposta de timócitos da prole jovem de ratos Wistar / Maternal protein deprivation during lactation increases leptin activity and inhibits apoptosis of thymic cells from young offspring
In this study, we investigated the consequences of maternal protein deprivation during lactation on thymocyte responses of the offspring Wistar rats (PD group) and the role of leptin in these alterations. Compared to group C, PD animals showed at 30 days of age, lower body and thymus weights, with no alteration in the thymocyte number or any difference in th
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 16/03/2011
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2. Efeitos da obesidade no sistema calicreína-cininas: estudo dos receptores b1 e b2 de cininas em tecido adiposo humano e murino. / Obesity, Leptin and Renin-Angiotensin System: Role on blood pressure control and autonomic regulation in ob/ob and db/db mice.
The leptin deficient ob/ob mice are insulin resistant and obese. However, the control of blood pressure in this model is not well defined. The goal of this study was to evaluate the role of leptin and the renin-angiotensin system (RAS) in the cardiovascular abnormalities observed in obesity using a model lacking leptin. Leptin is a hormone related to metabol
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 26/08/2009
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3. Exercício físico reduz a hiperglicemia de jejum em camundongos diabéticos através da ativação da AMPK
INTRODUÇÃO: A deficiência na captação de glicose em tecidos periféricos e o aumento da gliconeogênese hepática são fenômenos fisiopatológicos observados em pacientes diabéticos do tipo 2. O exercício físico é considerado um importante aliado para a melhora do perfil glicêmico em pacientes diabéticos; entretanto, os mecanismos envolvidos ness
Revista Brasileira de Medicina do Esporte. Publicado em: 2009-06
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4. Alterações histológicas, do fluxo portal e do óxido nítrico plasmático em ratos submetidos à obstrução/desobstrução biliar
OBJETIVO: Avaliar alterações hepáticas resultantes do processo de obstrução/desobstrução biliar. MÉTODOS: Trinta e nove ratos Wistar foram distribuídos aleatoriamente em 4 grupos: OB (n=18), oclusão biliar, seguimento de 20 dias, avaliação das alterações histológicas hepáticas, do fluxo portal e dosagens de NO e de malondialdeído (MDA); grup
Acta Cirurgica Brasileira. Publicado em: 2008
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5. "Estudo da influência de instrumentos e técnicas alternativas de preparo cavitário na resistência de união de sistema adesivos à dentina" / Study of the influence of alternative tools and techniques of cavity preparation on teh bond strength of adhesive system to dentin
The current trend toward minimal invasive dentistry has introduced alternative cavity preparation techniques. However, these technologies should not only fulfill the requirements of a conservative philosophy, but also prepare the cavity walls for the subsequent bonding restoration. The purpose of this study was to assess the null hypotheses that: (1) both co
Publicado em: 2007
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6. Dosagem serica da interleucina-8 (IL-8) em pacientes portadores de doença de Behçet e poliarterite nodosa
A patogênese da doença de Behçet (DB) e da poliarterite nodosa (PAN) não está totalmente esclareci da. No desencadeamento destas doenças provavelmente atuam diversos fenômenos interrelacionados, incluindo-se a produção de várias citocinas pró-inflamatórias. Neste estudo foi investigado o comportamento da interleucina-8 (IL-8) sérica em 21 pacien
Publicado em: 2000
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7. Increased expression in adipocytes of ob RNA in mice with lesions of the hypothalamus and with mutations at the db locus.
The gene product of the recently cloned mouse obese gene (ob) is important in regulating adipose tissue mass. ob RNA is expressed specifically by mouse adipocytes in vivo in each of several different fat cell depots, including brown fat. ob RNA is also expressed in cultured 3T3-442A preadipocyte cells that have been induced to differentiate. Mice with lesion
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8. OB protein binds specifically to the choroid plexus of mice and rats.
Binding studies were conducted to identify the anatomical location of brain target sites for OB protein, the ob gene product. 125I-labeled recombinant mouse OB protein or alkaline phosphatase-OB fusion proteins were used for in vitro and in vivo binding studies. Coronal brain sections or fresh tissue from lean, obese ob/ob, and obese db/db mice as well as le
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9. Defective STAT signaling by the leptin receptor in diabetic mice.
Leptin and its receptor, obese receptor (OB-R), comprise an important signaling system for the regulation of body weight. Splice variants of OB-R mRNA encode proteins that differ in the length of their cytoplasmic domains. We cloned a long isoform of the wild-type leptin receptor that is preferentially expressed in the hypothalamus and show that it can activ
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10. Trehalase activity in genetically diabetic mice (serum, kidney, and liver).
Trehalase activity was determined in serum, liver, and kidney in alloxan treated Swiss mice and in homozygous (Ob/Ob, Db/Db) and heterozygous (Ob/+, Db/m+) diabetic mice. Both alloxan and genetic diabetic mice exhibited a large increase in serum and liver trehalase activity with no change in kidney trehalase activity. The heterozygotes (Ob/+, Db/m+) showed o
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11. Selective deletion of leptin receptor in neurons leads to obesity
Animals with mutations in the leptin receptor (ObR) exhibit an obese phenotype that is indistinguishable from that of leptin deficient ob/ob mice. ObR is expressed in many tissues, including brain, and the relative importance of leptin’s effects on central versus peripheral sites has not been resolved. To address this, we generated mice with neuron-specifi
American Society for Clinical Investigation.
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12. Leptin-dependent platelet aggregation and arterial thrombosis suggests a mechanism for atherothrombotic disease in obesity
Obesity is associated with increased cardiovascular morbidity and mortality and with elevated circulating levels of the satiety factor leptin. This study provides evidence for a direct link between leptin and the risk for thrombotic complications in obese individuals. For example, although arterial injury provokes thrombosis in both lean and obese (ob/ob) mi
American Society for Clinical Investigation.