Olfactory Neuroepithelium
Mostrando 1-12 de 13 artigos, teses e dissertações.
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1. Olfactory neuroepithelium in the middle turbinate: is there any impact on olfaction function after lateral marsupialization for concha bullosa surgery?
Abstract Introduction: The effect of the quantity of olfactory neuroepithelium in the middle turbinate on the postoperative olfactory function for middle turbinate concha bullosa patients has not yet been evaluated. Objective: The primary aim of this study was to investigate the olfactory structures in the middle turbinate by immunohistochemical analysis o
Brazilian Journal of Otorhinolaryngology. Publicado em: 2022
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2. Olfactory neuroepithelium in the superior and middle turbinates: which is the optimal biopsy site?
INTRODUCTION: Olfactory neuroepithelium (ON) biopsy has several therapeutic applications for both disorders of olfaction and neurodegenerative diseases. Successful collection of ON is still anything but routine due to a dearth of studies on the distribution of ON in the superior and middle turbinates. AIM: To determine the location in which ON is most likely
Int. Arch. Otorhinolaryngol.. Publicado em: 2013-06
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3. Avaliação da cultura de células-tronco do epitélio olfatório de cães sem raça definida (Canis familiaris Linnaeus, 1758) / Evaluation of stem cell culture of olfactory epithelium from Mongrel dogs (Canis familiaris Linnaeus, 1758)
As células provenientes do epitélio olfatório apresentam capacidade regenerativa durante toda a vida, embora este mecanismo ainda não esteja completamente elucidado. O potencial de diferenciação de células-tronco provenientes do epitélio olfatório de cães sem raça definida (Canis familiaris Linnaeus, 1758) foi avaliado utilizando-se 12 cães adult
Publicado em: 2009
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4. Distribuição do neuroepitélio olfatório em concha média e superior em cadáveres humanos / Distribution of olfactory neuroepithelium in the middle and superior turbinate of human cadavers
INTRODUCTION: Olfactory neuroepithelium (ON) biopsy provides perspectives for several therapeutic applications, both in disorders of olfaction and in neurodegenerative diseases. Successful in vivo collection of ON is still not routine, due to a dearth of studies on ON distribution in the superior and middle turbinate (ST and MT respectively). This study desc
Publicado em: 2008
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5. Molecular cloning of olfactomedin, an extracellular matrix protein specific to olfactory neuroepithelium.
The extracellular mucous matrix of olfactory neuroepithelium is a highly organized structure in intimate contact with chemosensory cilia that house the olfactory transduction machinery. Here we describe the molecular cloning and primary structure of olfactomedin, which is the major component of this extracellular matrix. Olfactomedin is expressed exclusively
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6. Olfactory marker protein (OMP) gene deletion causes altered physiological activity of olfactory sensory neurons.
Olfactory marker protein (OMP) is an abundant, phylogentically conserved, cytoplasmic protein of unknown function expressed almost exclusively in mature olfactory sensory neurons. To address its function, we generated OMP-deficient mice by gene targeting in embryonic stem cells. We report that these OMP-null mice are compromised in their ability to respond t
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7. Olf-1-binding site: characterization of an olfactory neuron-specific promoter motif.
We report characterization of several domains within the 5' flanking region of the olfactory marker protein (OMP) gene that may participate in regulating transcription of this and other olfactory neuron-specific genes. Analysis by electrophoretic mobility shift assay and DNase I footprinting identifies two regions that contain a novel sequence motif. Interac
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8. A receptor guanylyl cyclase expressed specifically in olfactory sensory neurons.
We have cloned an additional member (GC-D) of the membrane receptor guanylyl cyclase [GTP pyrophosphate-lyase (cyclizing), EC 4.6.1.2] family that is specifically expressed in a subpopulation of olfactory sensory neurons. The extracellular, putative ligand-binding domain of the olfactory cyclase is similar in primary structure to two guanylyl cyclases expres
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9. Defective forebrain development in mice lacking gp330/megalin.
gp330/megalin, a member of the low density lipoprotein (LDL) receptor gene family, is expressed on the apical surfaces of epithelial tissues, including the neuroepithelium, where it mediates the endocytic uptake of diverse macromolecules, such as cholesterol-carrying lipoproteins, proteases, and antiproteinases. Megalin knockout mice manifest abnormalities i
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10. Evidence for distinct signaling mechanisms in two mammalian olfactory sense organs.
In mammals, olfactory stimuli are detected by sensory neurons at two distinct sites: the olfactory epithelium (OE) of the nasal cavity and the neuroepithelium of the vomeronasal organ (VNO). While the OE can detect volatile chemicals released from numerous sources, the VNO appears to be specialized to detect pheromones that are emitted by other animals and t
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11. A subset of olfactory neurons that selectively express cGMP-stimulated phosphodiesterase (PDE2) and guanylyl cyclase-D define a unique olfactory signal transduction pathway
Odorant information is encoded by a series of intracellular signal transduction events thought to be mediated primarily by the second messenger cAMP. We have found a subset of olfactory neurons that express the cGMP-stimulated phosphodiesterase (PDE2) and guanylyl cyclase-D (GC-D), suggesting that cGMP in these neurons also can have an important regulatory f
The National Academy of Sciences of the USA.
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12. Emx2 homeodomain transcription factor interacts with eukaryotic translation initiation factor 4E (eIF4E) in the axons of olfactory sensory neurons
We report that Emx2 homeogene is expressed at the mRNA and protein levels in the adult mouse olfactory neuroepithelium. As expected for a transcription factor, Emx2 is present in the nucleus of immature and mature olfactory sensory neurons. However, the protein is also detected in the axonal compartment of these neurons, both in the olfactory mucosa axon bun
National Academy of Sciences.