Olfactory Tubercle
Mostrando 1-12 de 30 artigos, teses e dissertações.
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1. Organization of ventral tegmental area projections to the striatum: an anterograde tracing study in the rat with the Phaseolus vulgaris leucoagglutinin technique / Organização das projeções da área tegmental ventral para o estriado. Um estudo no rato com a técnica de rastreamento anterógrado da leucoaglutina do Phaseolus vulgaris
A área tegmental ventral (VTA) contém neurônios dopaminérgicos do grupamento A10 e envia projeções muito densas para o estriado ventral. Esta circuitaria está crucialmente envolvida em mecanismos de recompensa. Recentemente, a organização destas projeções foi reexaminada por Ikemoto S. (Brain Res. Rev., 56:27-78, 2007), em um estudo de rastreament
Publicado em: 2010
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2. Dopamine receptor binding in inbred mice: strain differences in mesolimbic and nigrostriatal dopamine binding sites.
Dopamine receptors were examined by Scatchard analysis in the striatal and olfactory tubercle regions of 11 inbred mouse strains. Simultaneous determinations of the binding characteristics of 3H-labeled 2-amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene (ADTN), a dopaminergic agonist, and [3H]spiroperidol, a dopaminergic antagonist, were examined. Among the
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3. The olfactory tubercle, prepyriform cortex and precommisural region of the porpoise (Phocaena phocaena)
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4. Olfactory tubercle choline acetyltransferase activity in Alzheimer-type dementia, Down's syndrome and Huntington's chorea.
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5. OLFACTORY BULB REMOVAL: EFFECTS ON BRAIN NOREPINEPHRINE*
Removal of one olfactory bulb causes marked changes in the norepinephrine contents of several brain regions. The brainstem catecholamine level is higher on the side of the lesion than on the control side, whereas telencephalic norepinephrine is lower ipsilateral to the lesion. The apparent decline in telencephalic norepinephrine is associated with a parallel
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6. Dopamine-Sensitive Adenylate Cyclase in Mammalian Brain: A Possible Site of Action of Antipsychotic Drugs
Adenylate cyclase (EC 4.6.1.1), selectively stimulated by low concentrations of dopamine, has been found in the olfactory tubercle, the nucleus accumbens, and the caudate nucleus of several mammalian species. Several different classes of drugs effective in the treatment of schizophrenia (antipsychotic drugs) were potent inhibitors of the stimulation by dopam
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7. D-serine, an endogenous synaptic modulator: localization to astrocytes and glutamate-stimulated release.
Using an antibody highly specific for D-serine conjugated to glutaraldehyde, we have localized endogenous D-serine in rat brain. Highest levels of D-serine immunoreactivity occur in the gray matter of the cerebral cortex, hippocampus, anterior olfactory nucleus, olfactory tubercle, and amygdala. Localizations of D-serine immunoreactivity correlate closely wi
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8. Region-dependent dynamics of cAMP response element-binding protein phosphorylation in the basal ganglia
The cAMP response element-binding protein (CREB) is an activity-dependent transcription factor that is involved in neural plasticity. The kinetics of CREB phosphorylation have been suggested to be important for gene activation, with sustained phosphorylation being associated with downstream gene expression. If so, the duration of CREB phosphorylation might s
The National Academy of Sciences.
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9. Resolution of dopamine and serotonin receptor components of [3H]spiperone binding to rat brain regions.
A procedure was developed to identify receptors for dopamine and serotonin separately and selectively by means of [3H]spiperone and to measure the density of each receptor in different regions of the rat brain. In the striatum, the binding of [3H]spiperone to dopamine receptors was inhibited by sulpiride but not by quinazolinedone R43448 (R43448); in the fro
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10. Autoradiography of benzodiazepine receptor binding in the central nervous system of the normal C57BL6J mouse.
[3H]flunitrazepam has been used as a photoaffinity label for the specific, clonazepam-displaceable 1,4-benzodiazepine binding sites in sections of normal C57BL6J mouse brain and spinal cord. Binding was visualized by light microscope autoradiography and quantified by a simple microdensitometric procedure. Specific flunitrazepam binding was seen to be highest
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11. Immunocytochemical localization of beta II subspecies of protein kinase C in rat brain.
The distribution of a subspecies of protein kinase C (PKC) encoded by the beta II sequence in rat central nervous tissue was demonstrated immunocytochemically by using antibodies raised against an oligopeptide having a partial sequence specific for the beta II PKC. The beta II PKC immunoreactivity was widely but discretely distributed in the brain. The distr
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12. Distribution of D2 dopamine receptor mRNA in rat brain.
The distribution of mRNA coding for the D2 dopamine receptor was studied in the rat brain by in situ hybridization. A cDNA probe corresponding to the putative third cytosolic loop and sixth and seventh transmembrane domains of the rat D2 receptor was used to generate an 35S-labeled riboprobe to hybridize to D2 receptor mRNA. D2 mRNA was found both in dopamin