Oral Cancer Experimental Model
Mostrando 1-8 de 8 artigos, teses e dissertações.
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1. Amifostine reduces inflammation and protects against 5-fluorouracil-induced oral mucositis and hyposalivation
Oral mucositis (OM) is a common and dose-limiting side effect of cancer treatment, including 5-fluorouracil (5-FU) and radiotherapy. The efficacy of the therapeutic measures to prevent OM is limited and disease prevention is not fully observable. Amifostine is a cytoprotective agent with a described anti-inflammatory potential. It is clinically used to reduc
Braz J Med Biol Res. Publicado em: 25/02/2019
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2. Atividade da fosfoetanolamina sintética em melanoma murino experimental / Activity of synthetic phosphoethanolamine in experimental murine melanoma
The low responsiveness of melanoma to traditional treatments together with its increasing incidence makes the development of new therapeutic strategies against this type of cancer extremely important. In this study, we used a murine melanoma model to evaluate the effects of synthetic phosphoethanolamine (PEA) on the development of this tumor. In vitro, PEA h
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 06/11/2012
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3. Avaliação biomecânica da mandibulotomia / Biomechanical Evaluation of the Mandibulotomy Technique
Currently, cancer is still the cause of high death rates worldwide. Therefore, researchers are engaged in prevention and early diagnosis of this malignant disease that affects millions of people. Specifically in Brazil, it is recognized as a public health problem. Despide all efforts, the incidence of oral cancer in particular, is most often diagnosed in adv
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 04/04/2011
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4. Avaliação dos efeitos da hipertermoterapia por ultrasom associada a agentes antiangiogênicos no tratamento do tumor experimental de walker / EVALUATION OF THE HIPERTHERMOTHERAPY EFFECTS BY ULTRASOUND ASSOCIATED TO ANTIAGIOGENIC AGENTS IN THE TREATMENT OF WALKER EXPERIMENTAL TUMOR
The traditional methods of cancer treatment, like the chemotherapy and radiotherapy, even though they are effective in many types of tumours, they find frequently resistant neoplasic cells population, beyond presenting a low security margin to the patients. The hyperthermia use associated to the chemotherapy and radiotherapy are plenty mentioned as profitabl
Publicado em: 2009
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5. Metrotrexate and bisphosphonate alendronate effects on a experimental model of Walker 256 carcinosarcoma developed in rats mandible / Efeito do metotrexato e do bisfosfonato alendronato em modelo do carcinossarcoma 256 de Walker na mandíbula de ratos.
As reabsorções patológicas do osso alveolar vistas numa variedade de neoplasias malignas são severas e graves, levando precocemente a microfraturas. A invasão tumoral óssea pode acontecer em conseqüência da progressão subcortical do tumor através dos alvéolos dentários. O objetivo desse estudo foi avaliar o efeito do Metotrexato (MTX) e do Bisfos
Publicado em: 2005
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6. Espectroscopia de fluorescência na detecção de lesões quimicamente induzidas por agente carcinogênico na borda lateral da língua-estudo in vivo / Fluorescence spectroscopy to detection of chemically induced lesion at the lateral vorder of the tongue - in vivo study.
The diagnostic validity of the fluorescence spectroscopy in the discrimination of induced lesions at lateral border of the tongue of hamsters was investigated in this study. The animal model using chemical induction with DMBA (dimethylbenzanthracene) was chosen for the carcinogenesis phases comparable to the ones observed at oral cancer development in humans
Publicado em: 2005
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7. Amifostine effects avaliation in oral mucositis and disfunction of intestinal barrier: experimental model study in rats and in patients with cancer submitted a chemotherapy treatment / Avaliação dos efeitos do agente citoprotetor amifostina na mucosite oral e disfunção da barreira intestinal: modelos experimentais em ratos e em pacientes portadores de câncer submetidos à quimioterapia antineoplásica
A mucosite é um efeito colateral comum ao uso de antineoplásicos, podendo afetar áreas distintas do TGI resultando em estomatite e/ou diarréia que, somados a neutropenia podem culminar em quadro clínico grave. Em nosso estudo pretendeu-se, inicialmente, estudar em modelo experimental as ações da amifostina, um derivado Tiol com atividade de citoprote�
Publicado em: 2004
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8. Systemic immunization with papillomavirus L1 protein completely prevents the development of viral mucosal papillomas.
Infection of mucosal epithelium by papillomaviruses is responsible for the induction of genital and oral warts and plays a critical role in the development of human cervical and oropharyngeal cancer. We have employed a canine model to develop a systemic vaccine that completely protects against experimentally induced oral mucosal papillomas. The major capsid