Orexin
Mostrando 1-12 de 12 artigos, teses e dissertações.
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1. Participação do sistema da orexina na sensibilização comportamental ao efeito estimulante do etanol em camundongos machos / Role of orexin system in ethanol-induced behavioral sensitization in male mice
Orexins are two neuropeptides, orexin-A and orexin-B, derived from the same precursor gene (pre-pro-orexin) produced by a few thousand neurons located in the perifornical area of the lateral hypothalamus. Despite having a restricted production, orexinergic neurons project widely to brain structures that regulate a number of endocrine and homeostatic function
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 30/03/2011
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2. Estradiol-induced hypophagia is associated with the differential mRNA expression of hypothalamic neuropeptides
Estradiol participates in the control of energy homeostasis, as demonstrated by an increase in food intake and in body weight gain after ovariectomy in rats. In the present study, female Wistar rats (200-230 g, N = 5-15 per group), with free access to chow, were individually housed in metabolic cages. We investigated food intake, body weight, plasma leptin l
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-08
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3. Melanin-concentrating hormone and orexin A neuropeptidergic systems in the dorsal motor nucleus of the vagus nerve in rat / Sistema neuropeptidergico do hormonio concentrador de melanina e da orexina A no nucleo motor dorsal do nervo vago em rato
Melanin-concentrating hormone (MCH) and orexin-A (OXA) are neuromediators expressed in neurons distributed in the diencephalum, mainly in the lateral hypothalamic area, projecting nerve fibers to several parts of the central nervous system. These neuropeptides exert potent orexigenic activity, increasing feeding and controlling the energetic balance. Consequ
Publicado em: 2009
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4. Connections and neurochemical characterization of neural pathways involved in the control of jaw movements / Conexões e caracterização neuroquímica de vias neurais envolvidas com o controle dos movimentos mandibulares
O núcleo motor do trigêmeo (Mo5) está cercado por um anel de neurônios pré-motores localizados na região h. Estudos demonstram que neurônios que inervam o Mo5 estão distribuídos no tronco encefálico e no prosencéfalo. Após implante de traçador retrógrado no Mo5, verificamos células retrogradamente marcadas no núcleo mesencefálico do trigême
Publicado em: 2007
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5. Narcolepsia: muito além do sono; eficácia adaptativa do ego, equilíbrio psíquico e destinações inconscientes / Narcolepsy: way beyond sleep; ego\ s adaptive efficiency, psychological equilibrium and unconscious destinations
Narcolepsy is a chronic brain disorder characterized by excessive daytime sleepiness and sleep attacks. It affects up to one in a thousand people. Rapid eye movement (REM) sleep phenomena such as cataplexy, sleep paralysis and hypnagogic hallucinations can also occur. The condition impinges on every aspect of life, and can make it difficult for sufferers to
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 08/08/2003
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6. Orexin peptides prevent cataplexy and improve wakefulness in an orexin neuron-ablated model of narcolepsy in mice
Narcolepsy-cataplexy is a neurological disorder associated with the inability to maintain wakefulness and abnormal intrusions of rapid eye movement sleep-related phenomena into wakefulness such as cataplexy. The vast majority of narcoleptic-cataplectic individuals have low or undetectable levels of orexin (hypocretin) neuropeptides in the cerebrospinal fluid
National Academy of Sciences.
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7. Arousal effect of orexin A depends on activation of the histaminergic system
Orexin neurons are exclusively localized in the lateral hypothalamic area and project their fibers to the entire central nervous system, including the histaminergic tuberomammillary nucleus (TMN). Dysfunction of the orexin system results in the sleep disorder narcolepsy, but the role of orexin in physiological sleep–wake regulation and the mechanisms
National Academy of Sciences.
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8. Orexin A activates locus coeruleus cell firing and increases arousal in the rat
The localization of orexin neuropeptides in the lateral hypothalamus has focused interest on their role in ingestion. The orexigenic neurones in the lateral hypothalamus, however, project widely in the brain, and thus the physiological role of orexins is likely to be complex. Here we describe an investigation of the action of orexin A in modulating the arous
The National Academy of Sciences.
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9. Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems
We determined the immunohistochemical distributions of orexin-A and orexin-B, hypothalamic peptides that function in the regulation of feeding behavior and energy homeostasis. Orexin-A and -B neurons were restricted to the lateral and posterior hypothalamus, whereas both orexin-A and -B nerve fibers projected widely into the olfactory bulb, cerebral cortex,
The National Academy of Sciences.
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10. Antagonism of orexin receptor-1 in the retrotrapezoid nucleus inhibits the ventilatory response to hypercapnia predominantly in wakefulness
Recent data from transgenic mice suggest that orexin plays an important role in the ventilatory response to CO2 during wakefulness. We hypothesized that orexin receptor-1 (OX1R) in the retrotrapezoid nucleus (RTN) contributes to chemoreception. In unanaesthetized rats, we measured ventilation using a whole-body plethysmograph, together with EEG and EMG. We d
Blackwell Science Inc.
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11. A Major Role for Perifornical Orexin Neurons in the Control of Glucose Metabolism in Rats
American Diabetes Association.
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12. The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis
The cannabinoid receptor type 1 (CB1) and its endogenous ligands, the endocannabinoids, are involved in the regulation of food intake. Here we show that the lack of CB1 in mice with a disrupted CB1 gene causes hypophagia and leanness. As compared with WT (CB1+/+) littermates, mice lacking CB1 (CB1–/–) exhibited reduced spontaneous caloric intake and, as
American Society for Clinical Investigation.