Ospa
Mostrando 1-12 de 195 artigos, teses e dissertações.
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1. Seroprevalence of
Borrelia burgdorferi in occupationally exposed persons in the Belgrade area, SerbiaLyme disease (LD) is a natural focal zoonotic disease caused by
Borrelia burgdorferi, which is mainly transmitted through infectedIxodes ricinus tick bites. The presence and abundance of ticks in various habitats, the infectivity rate, as well as prolonged human exposure to ticks are factors that may affect the infectionBraz. J. Microbiol.. Publicado em: 2015-09
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2. "Com o apoio sincero dos seus dirigentes, como Moisés Vellinho e Machado Villa..."
- Porto Alegre - Teatro São Pedro - OSPA - Centro
Publicado em: 2007
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3. Lyme borreliosis in transgenic mice tolerant to Borrelia burgdorferi OspA or B.
The evolution of Lyme borreliosis in transgenic mice tolerant to Borrelia burgdorferi outer surface proteins (Osps) A or B was assessed to investigate the role of immunity to OspA or B in infection and pathogenesis of Lyme disease. Antibodies to OspA or B protect immunocompetent C3H/HeJ or C.B.17 severe combined immunodeficient (scid) mice from challenge wit
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4. Host-Adapted Borrelia burgdorferi in Mice Expresses OspA during Inflammation
Antibody responses to outer surface protein A (OspA) of Borrelia burgdorferi may occur during periods of arthritis late in the clinical course of untreated Lyme disease. These antibody responses are paradoxical, given the conclusive evidence demonstrating that B. burgdorferi transmitted to the mammalian host expresses little or no OspA. The parallel occurren
American Society for Microbiology.
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5. Role of attached lipid in immunogenicity of Borrelia burgdorferi OspA.
OspA is a protective antigen of the Lyme disease spirochete Borrelia burgdorferi. Expression of the full-length B. burgdorferi B31 OspA gene in Escherichia coli produces a protein that is processed posttranslationally by signal peptidase II and contains an attached lipid moiety. The recombinant OspA lipoprotein has been purified by detergent extraction and i
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6. OspA antibodies inhibit the acquisition of Borrelia burgdorferi by Ixodes ticks.
Ixodes ticks are infected by Borrelia burgdorferi when larvae feed on spirochete-infected mice. We studied the acquisition of B. burgdorferi by larval ticks, characterized the production of outer surface protein A (OspA) by spirochetes entering larvae, and examined the effects of OspA antibodies on the establishment of B. burgdorferi infections in ticks. Mos
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7. Outer surface lipoproteins of Borrelia burgdorferi activate vascular endothelium in vitro.
Previously, we reported that activation of vascular endothelium by the Lyme disease pathogen Borrelia burgdorferi results in enhanced expression of endothelial cell adhesion molecules and promotion of the transendothelial migration of neutrophils in vitro. To investigate the role of spirochetal lipoproteins in this process, we assessed the ability of a synth
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8. Attachment of Borrelia burgdorferi within Ixodes scapularis mediated by outer surface protein A
Borrelia burgdorferi outer surface protein (Osp) A has been used as a Lyme disease vaccine that blocks transmission: OspA antibodies of immune hosts enter ticks during blood feeding and destroy spirochetes before transmission to the host can occur. B. burgdorferi produce OspA in the gut of unfed Ixodes scapularis ticks, and many spirochetes repress OspA prod
American Society for Clinical Investigation.
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9. Transmission of Borrelia garinii OspA Serotype 4 to BALB/c Mice by Ixodes ricinus Ticks Collected in the Field
In Europe, Borrelia garinii OspA serotype 4 has been isolated from the cerebrospinal fluid of patients but, up to now, has never been identified among culture isolates from Ixodes ricinus ticks. This information raises the question of whether OspA serotype 4 is transmitted by I. ricinus in nature. In the present study, I. ricinus nymphs collected in an area
American Society for Microbiology.
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10. Roles of OspA, OspB, and flagellin in protective immunity to Lyme borreliosis in laboratory mice.
Vaccination with recombinant outer surface protein A (OspA) has been shown to protect mice from infection with Borrelia burgdorferi, the Lyme disease agent. To determine whether antibodies to B. burgdorferi proteins other than OspA are involved in protective immunity, antibodies to OspA were removed from protective anti-B. burgdorferi serum; the residual ser
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11. Abilities of OspA proteins from different seroprotective groups of Borrelia burgdorferi to protect hamsters from infection.
The ability of vaccination with recombinant OspA from six seroprotective groups of Borrelia burgdorferi sensu lato to induce protection against infection with homologous and other Lyme spirochetes was examined in hamsters. Antisera generated against the OspA proteins of B. burgdorferi sensu stricto S-1-10 and C-1-11 (seroprotective groups 1 and 2, respective
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12. Purification of Borrelia burgdorferi outer surface protein A (OspA) and analysis of antibody binding domains.
The major outer surface protein, OspA, of Borrelia burgdorferi is a lipoprotein which is a particular interest because of its potential as a vaccine candidate. However, serotypic and genetic analysis of OspA from both European and North American strains have demonstrated antigenic and structural heterogeneities. We purified OspA to homogeneity by exploiting