Osteoprogenitor Cells
Mostrando 1-12 de 12 artigos, teses e dissertações.
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1. Matriz porosa do BV60S associada a células osteoprogenitoras alógenas no tratamento de defeitos ósseos críticos em rádios de cães
RESUMO O objetivo do estudo foi avaliar o efeito da matriz porosa do biovidro 60S (BV60S) associada a células osteoprogenitoras (CO) alógenas no tratamento de defeitos ósseos críticos de cães. Foram utilizados 20 cães, machos, sem raça definida, com dois anos de idade e massa corporal média de 25kg. Com os cães sob anestesia geral, foram criados def
Arq. Bras. Med. Vet. Zootec.. Publicado em: 10/10/2019
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2. Engenharia de tecido ósseo: avaliações in vitro e in vivo do biomaterial híbrido ácido poli-láctico-co-glicólico/fosfato de cálcio e células osteoblásticas derivadas de células-tronco / Bone tissue engineering: in vitro and in vivo evaluation of hybrid biomaterial acid poly-lactic-co-glycolic/calcium phosphate and osteoblastic cells derived from stem cells
Tem sido sugerido que um adequado reparo ósseo pode ser obtido por biomateriais híbridos, produzidos pela combinação de células e materiais substitutos ósseos macroporosos. O objetivo geral do presente estudo foi avaliar a aplicação do biomaterial híbrido formado pelo arcabouço de PLGA/CaP e células-tronco mesenquimais e osteoblastos derivados de
Publicado em: 2010
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3. Avaliação de matrizes tridimensionais colagênicas como carreadores celulares para a bioengenharia óssea / Evaluation of three-dimensional collagenic matrices as cellular scaffolds to bone bioengineering
The therapy of bone defects constitutes one of the great challenges of the medicine and dentistry. Although autogenous is considered "gold standart", presents limitations as the necessity of second surgical site, limitation of bone availability and lack of previsibility. Tissue bioengineering appeared as a promising treatment for critical bone defects conjug
Publicado em: 2008
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4. Regulation of human bone marrow-derived osteoprogenitor cells by osteogenic growth factors.
Human bone marrow contains a distinct cell population that expresses bone proteins and responds to transforming growth factor beta 1 (TGF-beta), but not to hematopoietic growth factors (Long, M. W., J. L. Williams, and K. G. Mann. 1990. J. Clin. Invest. 86:1387-1395). We now report the isolation, characterization, and growth factor responsiveness of these pr
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5. The role of cartilage canals in the formation of secondary centres of ossification.
The present studies indicate that in the growth of cartilage canals the cartilage is removed by chondroclasts which stem from the primitive connective tissue cells of the perichondrium. Besides fusing to form multinucleated chondroclasts, these cells also provide the osteoblasts which establish the secondary centre of ossification. The growing tips of the bl
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6. Dlx3 Transcriptional Regulation of Osteoblast Differentiation: Temporal Recruitment of Msx2, Dlx3, and Dlx5 Homeodomain Proteins to Chromatin of the Osteocalcin Gene
Genetic studies show that Msx2 and Dlx5 homeodomain (HD) proteins support skeletal development, but null mutation of the closely related Dlx3 gene results in early embryonic lethality. Here we find that expression of Dlx3 in the mouse embryo is associated with new bone formation and regulation of osteoblast differentiation. Dlx3 is expressed in osteoblasts,
American Society for Microbiology.
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7. Bone deficit in ovariectomized rats. Functional contribution of the marrow stromal cell population and the effect of oral dihydrotachysterol treatment.
This study investigates the proliferative and osteogenic role of marrow stromal/osteoprogenitor cells in the development of the cortical bone deficit in ovariectomized (OVX) female rats. In vitro, clonal growth of marrow stromal cells from OVX rats was significantly impaired (vs. sham-operated controls). Yet in vivo, cells from sham-operated and OVX rats had
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8. Primitive adult hematopoietic stem cells can function as osteoblast precursors
Osteoblasts are continually recruited from stem cell pools to maintain bone. Although their immediate precursor is a plastic-adherent mesenchymal stem cell able to generate tissues other than bone, increasing evidence suggests the existence of a more primitive cell that can differentiate to both hematopoietic and mesenchymal cells. We show here that the “s
National Academy of Sciences.
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9. cDNA fingerprinting of osteoprogenitor cells to isolate differentiation stage-specific genes.
A cDNA fingerprinting strategy was developed to identify genes based on their differential expression pattern during osteoblast development. Preliminary biological and molecular staging of cDNA pools prepared by global amplification PCR allowed discrim-inating choices to be made in selection of expressed sequence tags (ESTs) to be isolated. Sequencing of sel
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10. Inhibition of Osteoblastic Cell Differentiation by Lipopolysaccharide Extract from Porphyromonas gingivalis
Lipopolysaccharide from Porphyromonas gingivalis (P-LPS), an important pathogenic bacterium, is closely associated with inflammatory destruction of periodontal tissues. P-LPS induces the release of cytokines and local factors from inflammatory cells, stimulates osteoclastic-cell differentiation, and causes alveolar bone resorption. However, the effect of P-L
American Society for Microbiology.
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11. The Osteogenic Transcription Factor Runx2 Controls Genes Involved in Sterol/Steroid Metabolism, Including Cyp11a1 in Osteoblasts
Steroid hormones including (1,25)-dihydroxyvitamin D3, estrogens, and glucocorticoids control bone development and homeostasis. We show here that the osteogenic transcription factor Runx2 controls genes involved in sterol/steroid metabolism, including Cyp11a1, Cyp39a1, Cyp51, Lss, and Dhcr7 in murine osteoprogenitor cells. Cyp11a1 (P450scc) encodes an approx
The Endocrine Society.
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12. PTHrP prevents chondrocyte premature hypertrophy by inducing cyclin-D1-dependent Runx2 and Runx3 phosphorylation, ubiquitylation and proteasomal degradation
In chondrocytes, PTHrP maintains them in a proliferative state and prevents premature hypertrophy. The mechanism by which PTHrP does this is not fully understood. Both Runx2 and Runx3 are required for chondrocyte maturation. We recently demonstrated that cyclin D1 induces Runx2 protein phosphorylation and degradation. In the present studies, we tested th
Company of Biologists.