Ouabain
Mostrando 1-12 de 617 artigos, teses e dissertações.
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1. Presynaptic neuromuscular action of a methanolic extract from the venom of Rhinella schneideri toad
Background Rhinella schneideri, previously known as Bufo paracnemis, is a common toad in many regions of Brazil. Its venom exerts important cardiovascular effects on humans and other animals. Although this toad venom has been the subject of intense investigations, little is known about its neuromuscular activity. Methods The neurotoxicity of a methanolic
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 02/09/2014
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2. Administração intrahipocampal de Ouabaína ativa o NF - kB e a sinalização da proteína WNTem ratos. / Intrahippocampal injection of Ouabain activates NF-kB and WNT signaling pathways in rats.
A enzima Na+, K+-ATPase é uma proteína de membrana altamente conservada em eucariotos, capaz de gerar um gradiente eletroquímico, fundamental para o balanço osmótico das células, o potencial de repouso das membranas e a propriedade excitatória das células musculares e nervosas. Além de seu papel regulatório na homeostasia iônica, desempenha um pap
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 16/02/2012
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3. Atividade imunomoduladora da ouabaína no processo inflamatório agudo / OUABAIN IMMUNOMODULATORY ACTIVITY IN THE ACUTE INFLAMMATORY PROCESS.
Ouabain (OUA), a potent inhibitor of the Na+,K+-ATPase pump, was identified as an endogenous substance of human plasma. In recent years, ouabain was shown to affect various immunological processes. Mechanisms that involve cellular differentiation, proliferation, activation and migration, as well as inflammatory mediators release, are activated during inflamm
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 15/02/2012
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4. Análise do efeito imunomodulador da ouabaína na inflamação e nocicepção
A Ouabaína é um glicosídeo cardiotônico, inibidor da Na+/K+-ATPase, utilizada na clínica para o tratamento de insuficiência cardíaca. Atualmente, sabe-se que essa substância é endógena, e capaz de interferir em várias funções fisiológicas, inclusive em diversos aspectos do sistema imunológico. Apesar disso, pouco se sabe sobre seu envolvimento
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 30/09/2011
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5. Hypertensive effects of the iv administration of picomoles of ouabain
Ouabain, an endogenous digitalis compound, has been detected in nanomolar concentrations in the plasma of several mammals and is associated with the development of hypertension. In addition, plasma ouabain is increased in several hypertension models, and the acute or chronic administration of ouabain increases blood pressure in rodents. These results suggest
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-09
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6. Efeito modulador da ouabaína no sistema imunológico
Initially known as a cardiotonic steroid capable to inhibit the Na+/K+ATPase, ouabain was identified as an endogenous substance present in human plasma, produced by the adrenal, pituitary and hypothalamus and can interfere with various aspects of immune response. In this study, which aimed to study the modulating effect of ouabain on the immune system in viv
Publicado em: 2011
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7. A low concentration of ouabain (0.18 µg/kg) enhances hypertension in spontaneously hypertensive rats by inhibiting the Na+ pump and activating the renin-angiotensin system
We investigated the effects of low ouabain concentrations on systolic (SAP) and diastolic (DAP) arterial pressures and on pressor reactivity in 3-month-old male spontaneously hypertensive rats (SHR). Arterial blood pressure (BP) and pressor reactivity to phenylephrine (PHE) were investigated before and after 0.18 μg/kg ouabain administration (N = 6). The in
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-08
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8. Caracterização cinética da (Na+, K+)-ATPase de animais juvenis e adultos durante a ontogenia do camarão de água doce M. amazonicum / Kinetic characterization of (Na +, K +)-ATPase of juvenile and adult animals during ontogeny of the freshwater shrimp M. amazonicum.
In the present work the kinetic characterization and biochemical properties of the (Na+, K+)-ATPase gill in ontogenetic stages of juvenile and adult freshwater prawn M. amazonicum was studied. In both stages of development the (Na+, K+)-ATPase was expressed as a molecular weight of 105 kDa. The stimulation of activity (Na+, K+)-ATPase by ATP in adult animals
Publicado em: 2010
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9. A key role for Na+/K+-ATPase in the endothelium-dependent oscillatory activity of mouse small mesenteric arteries
Oscillatory contractile activity is an inherent property of blood vessels. Various cellular mechanisms have been proposed to contribute to oscillatory activity. Mouse small mesenteric arteries display a unique low frequency contractile oscillatory activity (1 cycle every 10-12 min) upon phenylephrine stimulation. Our objective was to identify mechanisms invo
Brazilian Journal of Medical and Biological Research. Publicado em: 09/10/2009
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10. Ventricular performance and Na+-K+ ATPase activity are reduced early and late after myocardial infarction in rats
Myocardial infarction leads to compensatory ventricular remodeling. Disturbances in myocardial contractility depend on the active transport of Ca2+ and Na+, which are regulated by Na+-K+ ATPase. Inappropriate regulation of Na+-K+ ATPase activity leads to excessive loss of K+ and gain of Na+ by the cell. We determined the participation of Na+-K+ ATPase in ven
Brazilian Journal of Medical and Biological Research. Publicado em: 04/09/2009
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11. Papel dos rins na hipertensão arterial induzida pelo tratamento crônico com ouabaína em ratos. / Role of kidneys in ouabain-induced hypertension rats.
A Na+K+-ATPase (NKA) é uma proteína de membrana que participa de mecanismos de transporte nos túbulos renais para a reabsorção de sódio e outros substratos. Sabe-se que a administração de ouabaína (OUA), um inibidor da NKA, induz hipertensão arterial em ratos. No entanto, o papel dos rins nesse modelo de hipertensão não está bem elucidado. Desta
Publicado em: 2009
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12. Purificação e caracterização parcial de ATPase de larvas de Zabrotes subfasciatus (Coleóptera: Chrysomelidae: Bruchinae) e modulação fitoterápica de sua atividade
Zabrotes subfasciatus is the most common pest of the stored beans (Phaselous vulgaris). This study was carried out to characterize ATPase from Z. subfasciatus larvae and to investigate its phytotherapy modulation. Larvae extracted from Phaseolus vulgaris were firstly homogenised in extraction buffer, and then centrifuged 45000g for 30min at 4C. Supernatant w
Publicado em: 2009