Ovarian Steroid Hormones
Mostrando 1-12 de 13 artigos, teses e dissertações.
-
1. Characterization of proteoglycans in the mouse uterus during the estrous cycle and in ovariectomized animals: analysis of the effects of castration and hormone replacement. / Caracterização de proteoglicanos do útero de camundongos durante o ciclo estral e em animais ovarectomizados: análise dos efeitos da castração e da reposição hormonal.
A matriz extracelular (MEC) dos tecidos uterinos é altamente remodelada na gestação de camundongos. Os objetivos deste estudo foram avaliar a influência dos hormônios ovarianos estrógeno (E2) e progesterona (P4) sobre a estrutura dos tecidos uterinos de camundongo e a deposição dos proteoglicanos decorim, biglicam, fibromodulim, lumicam, perlecam e v
Publicado em: 2009
-
2. Blastocyst-endometrium interaction: intertwining a cytokine network
The successful implantation of the blastocyst depends on adequate interactions between the embryo and the uterus. The development of the embryo begins with the fertilized ovum, a single totipotent cell which undergoes mitosis and gives rise to a multicellular structure named blastocyst. At the same time, increasing concentrations of ovarian steroid hormones
Brazilian Journal of Medical and Biological Research. Publicado em: 22/09/2006
-
3. Role of Estradiol in Cortisol-Induced Reduction of Luteinizing Hormone Pulse Frequency
Precise control of pulsatile GnRH and LH release is imperative to ovarian cyclicity but is vulnerable to environmental perturbations, like stress. In sheep, a sustained (29 h) increase in plasma cortisol to a level observed during stress profoundly reduces GnRH pulse frequency in ovariectomized ewes treated with ovarian steroids, whereas shorter infusion (6
The Endocrine Society.
-
4. Estrogen, Progesterone and Epithelial Ovarian Cancer
Ovarian carcinoma (OCa) continues to be the leading cause of death due to gynecologic malignancies and the vast majority of OCa is derived from the ovarian surface epithelium (OSE) and its cystic derivatives. Epidemiological evidence strongly suggests that steroid hormones, primarily estrogens and progesterone, are implicated in ovarian carcinogenesis. Howev
BioMed Central.
-
5. Tumour-stromal interactions: Reciprocal regulation of extracellular matrix proteins and ovarian steroid activity in the mammary gland
Despite the critical importance of ovarian steroids in the treatment of breast cancer, little is known about the acquisition or loss of estrogen and progesterone responsiveness in either the normal or neoplastic mammary gland. This review focuses on the interactions among mammary stroma-derived extracellular matrix (ECM) proteins, integrins and ovarian hormo
BioMed Central.
-
6. Steroid hormones induce HMG1 overexpression and sensitize breast cancer cells to cisplatin and carboplatin
Cisplatin is an anticancer drug that has enjoyed remarkable success against testicular tumors, but dose limiting side-effects have limited its application against a broader range of cancers. Previous studies have shown that high-mobility group (HMG) domain proteins such as HMG1 sensitize cells to cisplatin by shielding its major DNA adducts from nucleotide e
The National Academy of Sciences.
-
7. Modulation of cognition-specific cortical activity by gonadal steroids: A positron-emission tomography study in women
There is considerable evidence from animal studies that gonadal steroid hormones modulate neuronal activity and affect behavior. To study this in humans directly, we used H215O positron-emission tomography to measure regional cerebral blood flow (rCBF) in young women during three pharmacologically controlled hormonal conditions spanning 4–5 months: ovarian
National Academy of Sciences.
-
8. Vascular endothelial growth factor is produced by peritoneal fluid macrophages in endometriosis and is regulated by ovarian steroids.
Angiogenesis is important in the pathophysiology of endometriosis, a condition characterized by implantation of ectopic endometrium in the peritoneal cavity. Vascular endothelial growth factor (VEGF) is a potent angiogenic factor involved in physiological and pathological angiogenesis, and elevated levels of VEGF are found in peritoneal fluid of patients wit
-
9. Cochaperone immunophilin FKBP52 is critical to uterine receptivity for embryo implantation
Embryo implantation in the uterus is a critical step in mammalian reproduction, requiring preparation of the uterus receptive to blastocyst implantation. Uterine receptivity, also known as the window of implantation, lasts for a limited period, and it is during this period blastocysts normally implant. Ovarian steroid hormones estrogen and progesterone (P4)
National Academy of Sciences.
-
10. Papillary hidradenoma: immunohistochemical analysis of steroid receptor profile with a focus on apocrine differentiation.
AIM: To make a quantitative evaluation by image analysis of oestrogen receptors, progesterone receptors, and androgen receptors in papillary hidradenomas and anogenital sweat glands. METHODS: 20 papillary hidradenomas and the anogenital sweat glands detected in surgical specimens selected from 10 vulvectomies for squamous carcinoma, eight haemorrhoidectomies
-
11. Transcriptome analysis reveals an unexpected role of a collagen tyrosine kinase receptor gene, Ddr2, as a regulator of ovarian function
Mice homozygous for the smallie (slie) mutation lack a collagen receptor, discoidin domain receptor 2 (DDR2), and are dwarfed and infertile due to peripheral dysregulation of the endocrine system of unknown etiology. We used a systems biology approach to identify biological networks affected by Ddr2slie/slie mutation in ovaries using microarray analysis and
American Physiological Society.
-
12. A membrane-associated progesterone-binding protein, 25-Dx, is regulated by progesterone in brain regions involved in female reproductive behaviors
The ventromedial hypothalamus (VMH) plays a central role in the regulation of the female reproductive behavior lordosis, a behavior dependent upon the sequential activation of receptors for the ovarian steroid hormones estradiol (E) and progesterone (P). These receptors function as transcription factors to alter the expression of target genes. To discov
The National Academy of Sciences.