Oxamniquine
Mostrando 1-12 de 40 artigos, teses e dissertações.
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1. Clinical-epidemiological and laboratory profiles of severe Schistosomiasis mansoni infections at a university hospital
OBJECTIVE: Schistosomiasis remains a public health problem. This was a descriptive and retrospective study of 42 patients with a severe form of schistosomiasis who were admitted to the outpatient clinic of the Faculdade de Medicina da Universidade de São Paulo, São Paulo, in São Paulo, Brazil. METHODS: A data collection questionnaire was designed from t
Clinics. Publicado em: 21/09/2018
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2. Antischistosomal activity from Brazilian marine algae
Abstract Schistosomiasis may be caused by six different species of the genus Schistosoma. Current treatment is based only on two drugs: oxamniquine, which is only effective against the Schistosoma mansoni species, and praziquantel, which is ineffective against young parasites. Therefore, research on new drugs and their targets for the treatment of this disea
Rev. bras. farmacogn.. Publicado em: 2015-12
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3. Schistogram changes after administration of antischistosomal drugs in mice at the early phase of Schistosoma mansoni infection
Mice infected with Schistosoma mansoni were treated with oxamniquine, praziquantel, artesunate at the pre-patent phase, aiming at observing schistogram alterations. Half of the animals were perfused five days post-treatment for counting and classification of immature worms, based on pre-established morphological criteria (schistogram); the remaining animals
Mem. Inst. Oswaldo Cruz. Publicado em: 2013-11
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4. Ação de cordia verbenacea sobre schistosoma mansoni / Activity of cordia verbenacea on schistosoma mandoni
The trematode Schistosoma mansoni is responsible for causing a form of schistosomiasis that kills around 280,000 people each year. Since there are cases of tolerance and resistance to the drugs currently used in the treatment for this disease, namely praziquantel (PZQ) and oxamniquine, there is a need for new schistosomicidal drugs. In that regard, the resea
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 17/01/2012
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5. Avaliação de estratégias de vacinação \"prime-boost\" na infecção experimental por Schistosoma mansoni empregando vacinas de DNA / Evaluation of prime-boost vaccination strategies against Schistosoma mansoni experimental infection applying DNA vaccines.
A esquistossomose é uma das mais relevantes doenças induzidas por helmintos, acometendo cerca de 207 milhões de pessoas em todo o mundo. O Praziquantel e o Oxamniquine são os fármacos empregados no tratamento, mas além de não impedirem re-infecções, não atuam nos estágios imaturos do verme. Portanto, o desenvolvimento de uma estratégia de vacina�
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 20/06/2011
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6. Estudo proteômico de vermes adultos machos e fêmeas de Schistosoma mansoni / Proteomic studies of male and female Schistosoma mansoni adult worms
Schistosomiasis is a neglected tropical disease that affects approximately 200 million people around the world, occurring in America, Africa, the Antilles, Middle East and Near East, besides Southeast Asia. The species found in Brazil is Schistosoma mansoni, the typical treatment being administration of either Praziquantel or Oxamniquine. Although, the infec
Publicado em: 2011
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7. Specific schistosomiasis treatment as a strategy for disease control
The great hope for schistosomiasis treatment began with the development of oxamniquine and praziquantel. These drugs can be administered orally in a single dose and have a high curative power with minor side effects. In this study, we carried out a field experiment involving a population of 3,782 people. The population was examined at four localities in Mina
Memórias do Instituto Oswaldo Cruz. Publicado em: 2010-07
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8. Antibody reactivity against potato apyrase, a protein that shares epitopes with Schistosoma mansoni ATP diphosphohydrolase isoforms, in acute and chronically infected mice, after chemotherapy and reinfection
Schistosoma mansoni ATP diphosphohydrolase isoforms and potato apyrase share conserved epitopes. By enzyme-linked immunosorbent assays, elevated levels of IgM, IgG2a and IgG1 antibody reactivity against potato apyrase were observed in S. mansoni-infected BALB/c mice during the acute phase of infection, while only IgM and IgG1 antibody reactivity levels maint
Memórias do Instituto Oswaldo Cruz. Publicado em: 2010-07
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9. Association of oxamniquine praziquantel and clonazepam in experimental Schistosomiasis mansoni
The antischistosomal activity of clonazepam, when administered alone or in association with oxamniquine and praziquantel, was experimentally evaluated in mice infected with Schistosoma mansoni. The animals were treated 45 days post-infection with a single dose, by oral route, according to three treatment schedules: clonazepam 25 mg/kg and sacrificed 15 min,
Memórias do Instituto Oswaldo Cruz. Publicado em: 2008-12
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10. Esquistossomose ectópica: descrição de cinco casos de envolvimento da pele, um do ovário e um da glândula supra-renal
São apresentados sete casos de esquistossomose ectópica (cinco de pele, um de ovário e um de supra-renal) procedentes do Estado de Sergipe, coletados a partir de pesquisa de prontuários e laudos anátomo-patológicos nos arquivos dos Serviços de Dermatologia e de Patologia do Hospital Universitário da Universidade Federal de Sergipe, entre os anos de 1
Revista da Sociedade Brasileira de Medicina Tropical. Publicado em: 2008-12
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11. Oxamniquine, praziquantel and lovastatin association in the experimental Schistosomiasis mansoni
The activity of lovastatin associated with oxamniquine or praziquantel against schistosomiasis mansoni was evaluated in mice infected with Schistosoma mansoni. Forty days after infection, mice were treated with lovastatin, 400 mg/kg for five consecutive days by oral route, and on the last day of this sequence with 50 mg/kg oxamniquine or with 200 mg/kg prazi
Memórias do Instituto Oswaldo Cruz. Publicado em: 2008-08
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12. Ultra-sonografia abdominal na avaliação de fibrose e hipertensão portal em área de baixa endemicidade de esquistossomose
Este estudo desenvolveu-se no município de Bananal, São Paulo, uma área endêmica para esquistossomose com prevalência menor que 10% e baixa carga parasitária nos infectados. Teve como objetivo a identificação de formas clínicas da esquistossomose mansoni através do exame ultra-sonográfico, em 109 pacientes diagnosticados parasitologicamente e medi
Revista do Instituto de Medicina Tropical de São Paulo. Publicado em: 2008-04