P53 Arg Pro Polymorphism
Mostrando 1-12 de 15 artigos, teses e dissertações.
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1. Lack of evidence of HPV etiology of prostate cancer following radical surgery and higher frequency of the Arg/Pro genotype in turkish men with prostate cancer
ABSTRACT Objectives The aim of this study was to assess the possible role of HPV in the development of prostate cancer (PCa) and investigate the distribution of the p53 codon 72 polymorphism in PCa in a Turkish population. Materials and methods A total of 96 tissues, which had been obtained using a radical surgery method, formalin-fixed and parafin-embed
Int. braz j urol.. Publicado em: 2017-02
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2. Association of XRCC1 Arg399GIn and Tp53 Arg72Pro polymorphisms and increased risk of uterine leiomyoma - A case-control study
Abstract The aim of present study was to investigate the role of the X-ray repair cross-complementing protein1 (XRCC1) and Tumor protein p53 (Tp53) polymorphisms in Uterine Leiomyoma (UL) susceptibility in southeastern Iran. This case control study was performed on 139 women with UL and 149 age, BMI and ethnicity matched healthy women. All women were genotyp
Genet. Mol. Biol.. Publicado em: 24/11/2015
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3. Influência dos polimorfismos P53 ARG72PRO, MDM2 T309G, BCL2 C(-938)A e BAX G(-248)A, relacionados com apoptose celular, na susceptibilidade ao melanoma cutâneo = : Influence of the polymorphisms P53 ARG72PRO, MDM2 T309G, BCL2 C (-938) A and BAX G (-248) A, involved with cellular apoptosis, incutaneous melanoma susceptibility / Influence of the polymorphisms P53 ARG72PRO, MDM2 T309G, BCL2 C (-938) A and BAX G (-248) A, involved with cellular apoptosis, incutaneous melanoma susceptibility
The P53 and BAX (proapoptotic) and MDM2 and BCL2 (antiapoptotic) genes remove cells damaged by ultraviolet (UV) rays of the sunlight and, therefore, are related to the cutaneous melanoma (CM) origin. The Arg wild allele of the P53 Arg72Pro polymorphism is more efficient in inducing apoptosis than the variant Pro allele. The variant G and A alleles of the MDM
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 12/06/2012
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4. Role of p53 codon 72 polymorphism in chromosomal aberrations and mitotic index in patients with chronic hepatitis B
Polymorphisms of the p53 gene, which participates in DNA repair, can affect the functioning of the p53 protein. The Arg and Pro variants in p53 codon 72 were shown to have different regulation properties of p53-dependent DNA repair target genes that can affect various levels of cytogenetic aberrations in chronic hepatitis B patients. The present study aimed
Braz J Med Biol Res. Publicado em: 2012-11
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5. Estudo de associação do polimorfismo de base única no códon 72 do gene humano p53 e as características de pigmentação / Association study of single-base polymorphism at codon 72 of human p53 gene and characteristics of pigmentation
O gene p53 codifica uma proteína à qual exerce várias funções como monitoramento do ciclo celular, atuação em mecanismos de reparo e apoptose. Novas funções exercidas por essa proteína vêm sendo observadas e estudadas como a atuação na cascata de pigmentação da pele agindo como fator de transcrição para genes importantes nesse processo como
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 30/03/2010
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6. Association study of single-base polymorphism at codon 72 of human p53 gene and characteristics of pigmentation / Estudo de associação do polimorfismo de base única no códon 72 do gene humano p53 e as características de pigmentação
O gene p53 codifica uma proteína à qual exerce várias funções como monitoramento do ciclo celular, atuação em mecanismos de reparo e apoptose. Novas funções exercidas por essa proteína vêm sendo observadas e estudadas como a atuação na cascata de pigmentação da pele agindo como fator de transcrição para genes importantes nesse processo como
Publicado em: 2010
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7. O polimorfismo do gene p5372(RP) no câncer de cabeça e pescoço: estudo de associação e meta-análise / p5372(RP) polymorphism in head and neck cancer: an association and meta-analysis study
O câncer de cabeça e pescoço ocorre nas regiões da cavidade oral, da faringe (orofaringe, nasofaringe e hipofaringe) e da laringe. Aspectos epidemiológicos evidenciam a etiologia multifatorial das neoplasias de cabeça e pescoço, destacando, o tabagismo e o etilismo crônicos como principais fatores de risco, seguidos dos aspectos nutricionais, infecç
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 20/10/2009
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8. Primary open angle glaucoma was not found to be associated with p53 codon 72 polymorphism in a Brazilian cohort / Glaucoma primário de ângulo aberto não associado ao polimorfismo do codon 72 do gene p53 em pacientes brasileiros
Glaucoma primário de ângulo aberto (GPAA) é o tipo de glaucoma mais comum. O polimorfismo Arg-Pro (CGC para CCC) no exon 4 do codon 72 do gene p53 afeta várias propriedades biológicas; recentemente foi publicado que este afeta a indução da apoptose in vitro. Vários genótipos têm sido associados significantemente ao GPAA. Nós analisamos a distribui
Publicado em: 2009
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9. POLIMORFISMO DO GENE TP53 EM SARCOMAS DE PARTES MOLES NO ADULTO
Soft tissue sarcomas (STS) are tumors with mesodermical origin, comprising about 1% of all adult neoplasms. Because of its effect on the p53 protein coding sequence, and its association with an increased risk for some cancer types, TP53 codon 72 polymorphism has been investigated in several studies. TP53 codon 72 codes for either Arginine (p53Arg), or Prolin
Publicado em: 2008
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10. TP53 codon 72 polymorphism as a risk factor for cardiovascular disease in a Brazilian population
TP53, a tumor suppressor gene, has a critical role in cell cycle, apoptosis and cell senescence and participates in many crucial physiological and pathological processes. Identification of TP53 polymorphism in older people and age-related diseases may provide an understanding of its physiology and pathophysiological role as well as risk factors for complex d
Brazilian Journal of Medical and Biological Research. Publicado em: 22/10/2007
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11. Estudo dos herpesvirus humanos tipo 6 e tipo 1 e sua inter-relação com o gene TP53 em diferentes condições patologicas / Study of herpes viruses types 6 and type 1 and their relationship with TP53 gene in distinct pathological conditions
Interactions between viruses, the immune system and detoxifying enzymes have been associated to the etiology of many conditions including cancer and various autoimmune diseases. We investigated the role of herpes viruses type 6 (HHV-6) and 1 (HHV-1) and the codon 72 (P72) and codon 47 (S47) variants of exon 4 of TP53, responsible for a diminished antiapoptot
Publicado em: 2007
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12. Prevalence of codon 72 P53 polymorphism in Brazilian women with cervix cancer
The p53 codon 72 polymorphism seems to be associated with HPV-carcinogenesis, although controversial data have been reported. A series of Brazilian women with cervix carcinomas were analyzed. Ninety-nine (67%) of 148 women were found to be homozygous (arg/arg) for the arginine polymorphism, and 49 (33%) were heterozygous (arg/pro). This polymorphism may be a
Genetics and Molecular Biology. Publicado em: 2004