Pamam Dendrimer
Mostrando 1-11 de 11 artigos, teses e dissertações.
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1. Ancoramento de nitrosilo complexo de rutênio em dendrímeros PAMAM e estudo de suas propriedades químicas e biológicas / Anchoring ruthenium nitrosyl complex on PAMAM dendrimer and chemical and biological properties
O ancoramento do complexo trans-[RuIII(NH3)4(SO4)ina]Cl em dendrímeros PAMAM de geração 0 e 2 (G0 e G2) foi realizada por meio de uma ligação peptídica, e esses produtos foram submetidos à reação com NO(g) gerando os respectivos nitrosilo complexos G0/RuNO e G2/RuNO. A caracterização desses compostos por infravermelho, UV-vis, voltametria cíclica
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 14/07/2011
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2. Solubility improvement of an anthelmintic benzimidazole carbamate by association with dendrimers
The improvement of aqueous solubility of methyl (5-[propylthio]-1H-benzimidazol-2-yl) carbamate, albendazole (ABZ) using polyamidoamine (PAMAM) dendrimers as solubility enhancers was investigated. Full generation PAMAM dendrimers with amine terminal groups, (G3), with hydroxyl terminal groups (G3OH) and half generation PAMAM dendrimers with carboxylate termi
Brazilian Journal of Chemical Engineering. Publicado em: 2011-12
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3. Dendrímeros como carreadores da protoporfirina IX para a terapia fotodinâmica tópica do câncer de pele / Dendrimers as drug carriers for protoporphyrin IX to topical photodynamic therapy of skin cancer.
A protoporfirina IX (PpIX) é uma substância fotodinâmicamente ativa, entretanto, devido a sua alta lipofilia apresenta dificuldades para penetrar nas camadas mais profundas da pele, não sendo administrada topicamente. Assim, o objetivo deste trabalho é estudar a influência de diferentes tipos de dendrímeros de poliamidoamina (PAMAM) na solubilidade, p
Publicado em: 2011
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4. Filmes nanoestruturados contendo lipossomos para liberação controlada do Ibuprofeno / Nanostructured films containing liposomes for controlled release of ibuprofen
Controlled drug delivery is a key issue in a number of nanotechnology endeavors owing to the large impact on society that may achieved if improved systems are created which allows for delivery at a specific target and with a controlled rate. Among the various paradigms employed in drug delivery, the use of liposomes is prominent because a variety of drug mol
Publicado em: 2008
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5. Study of photoinduced birefrigence, in layer-by-layer films containing azopolymer and azodye / Estudo de birrefrigência fotoinduzida em filmes automontados de azopolímeros e azocorantes
This work was aimed at investigating the influence of the molecular architecture and film fabrication on the photoinduced birefi-ingence of layer-by-layer (LbL) films containing the azopolymer PS 119® or the azodye Brylliant Yellow (BY) as photoreactive materials. The LbL films were produced with six polications, viz.: poly(allylamine hydrochloride) (PAH),
Publicado em: 2005
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6. Partial shell-filled core-shell tecto(dendrimers): A strategy to surface differentiated nano-clefts and cusps
Poly(amidoamine) (PAMAM) dendrimer shell reagents possessing either nucleophilic (i.e., primary amines) or electrophilic (i.e., carboxymethyl esters) functional groups have been covalently assembled around appropriate electrophilic or nucleophilic dendrimer core reagents to produce partial shell filled/core-shell tecto(dendrimers). Partial shell-filled produ
National Academy of Sciences.
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7. Enhanced delivery of antisense oligonucleotides with fluorophore-conjugated PAMAM dendrimers
PAMAM dendrimers are cationic polymers that have been used for the delivery of genes and oligonucleotides to cells. However, little is known about the behavior of dendrimer–nucleic acid complexes once they reach the cell interior. To pursue this issue, we prepared dendrimers conjugated with the fluorescent dye Oregon green 488. These were used in conjuncti
Oxford University Press.
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8. Poly(amidoamine) (PAMAM) dendritic nanostructures for controlled sitespecific delivery of acidic anti-inflammatory active ingredient
The purpose of the investigation was to evaluate the potential of polyamidoamine (PAMAM) dendrimer as nanoscale drug delivery units for controlled release of water insoluble and acidic anti-inflammatory drug. Flurbiprofen (FB) was selected as a model acidic anti-inflammatory drug. The aqueous solutions of 4.0 generation (G) PAMAM dendrimer in different conce
Springer-Verlag.
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9. PEG-conjugated PAMAM Dendrimers Mediate Efficient Intramuscular Gene Expression
Generations 5 and 6 (G5 and G6) poly(amidoamine) (PAMAM) dendrimers have been shown to be highly efficient nonviral carriers in in vitro gene delivery. However, their high toxicity and unsatisfied in vivo efficacy limit their applications. In this study, to improve their characteristics as gene delivery carriers, polyethylene glycol (PEG, molecular weight 5,
Springer US.
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10. DNA microarrays with PAMAM dendritic linker systems
The DNA microarray-based analysis of single nucleotide polymorphisms (SNPs) is important for the correlation of genetic variations and individual phenotypes, and for locating disease-causing genes. To facilitate the development of surfaces suitable for immobilization of oligonucleotides, we report here a novel method for the surface immobilization of DNA usi
Oxford University Press.
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11. Regulation of in vitro gene expression using antisense oligonucleotides or antisense expression plasmids transfected using starburst PAMAM dendrimers.
Starburst polyamidoamine (PAMAM) dendrimers are a new type of synthetic polymer characterized by a branched spherical shape and a high density surface charge. We have investigated the ability of these dendrimers to function as an effective delivery system for antisense oligonucleotides and 'antisense expression plasmids' for the targeted modulation of gene e