Paracrine Interaction
Mostrando 1-12 de 33 artigos, teses e dissertações.
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1. FGF2 species of 18 and 22.5 kDa: paracrine molecular signaling and biological functions / FGF2 de 18kDa e de 22,5kDa: sinalização molecular parácrina e funções biológias
FGF2 (Fibroblast Growth Factor 2), the founder of the FGF family, has regulatory functions in mitogenesis, differentiation, morphogenesis and tissue repair. Multiple FGF2 molecular species, sharing a C-terminal sequence of 155 amino acids, are translated from different iniciation sites of the same mRNA. The smaller, the FGF2-18kD, is extracellularly released
Publicado em: 2010
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2. Papel da interação parácrina entre astrócitos e pinealócitos na mediação do efeito potenciador da angiotensina II sobre a síntese de melatonina induzida pela estimulação noradrenérgica na glândula pineal de ratos. / Paracrine interaction between glial cells and pinealocytes determines the potentiating effects of angiotensin II on noradrenaline-stimulated melatonin synthesis on the rat pineal gland.
We have previously demonstrated that Angiotensin II (Ang II) potentiates the noradrenaline-stimulated (Nor+) melatonin synthesis in the rat pineal gland [Baltatu et al.,J. Neurochem.(2002)80, 328-334]. The aim of the present paper was to study the possible paracrine interactions between glial cells and pinealocytes in the rat pineal gland. To accomplish this
Publicado em: 2008
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3. The LRP5 High-Bone-Mass G171V Mutation Disrupts LRP5 Interaction with Mesd
The mechanism by which the high-bone-mass (HBM) mutation (G171V) of the Wnt coreceptor LRP5 regulates canonical Wnt signaling was investigated. The mutation was previously shown to reduce DKK1-mediated antagonism, suggesting that the first YWTD repeat domain where G171 is located may be responsible for DKK-mediated antagonism. However, we found that the thir
American Society for Microbiology.
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4. What brings pericytes to tumor vessels?
Paracrine signaling via platelet-derived growth factor B (PDGFB), expressed by endothelial cells, and its receptor PDGFR-β, expressed by pericytes, plays a central role in blood vessel maturation. A new study reveals that it is not just the presence of PDGFB, but how it is presented to pericytes, that determines the quality of the endothelium-pericyte inter
American Society for Clinical Investigation.
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5. Effects of interleukin-1 beta on insulin-like growth factor-I autocrine/paracrine axis in cultured rat articular chondrocytes.
OBJECTIVE--To clarify the interaction of tissue destruction and repair of articular cartilage during inflammation, the effects of interleukin-1 beta (IL-1 beta) on the expression of insulin-like growth factor I (IGF-I), its receptor, and its binding proteins were examined. METHODS--Articular chondrocytes from five week rats were cultured in serum free medium
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6. Induction of a Potential Paracrine Angiogenic Loop between Human THP-1 Macrophages and Human Microvascular Endothelial Cells during Bartonella henselae Infection
Bartonella henselae is responsible for various disease syndromes that loosely correlate with the immune status of the host. In the immunocompromised individual, B. henselae-induced angiogenesis, or bacillary angiomatosis, is characterized by vascular proliferative lesions similar to those in Kaposi's sarcoma. We hypothesize that B. henselae-mediated interact
American Society for Microbiology.
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7. Leukemia inhibitory factor (LIF) and LIF receptor expression in human endometrium suggests a potential autocrine/paracrine function in regulating embryo implantation.
The uterine expression of leukemia inhibitory factor (LIF) is essential for embryo implantation in the mouse. Here, we describe the expression of LIF, related members of this group of cytokines, oncostatin M and ciliary neurotrophic factor, and the LIF receptor beta and glycoprotein gp130 in normal human tissues and in the endometrium of fertile women. Our r
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8. Fibroblasts modulate intestinal secretory responses to inflammatory mediators.
Cultured colonic epithelial cells and fibroblasts were used to examine the interaction between these cell types during intestinal secretion. Secretory responses of T84 colonic epithelial cells, measured as changes in the short-circuit current in modified Ussing chambers to bradykinin, serotonin, hydrogen peroxide, and histamine, were enhanced in the presence
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9. Natriuretic peptides inhibit angiotensin II-induced proliferation of rat cardiac fibroblasts by blocking endothelin-1 gene expression.
The present study was aimed to test the role of endothelin-1 (ET-1) as a possible autocrine/paracrine growth factor for cardiac fibroblasts, and to examine its interaction with cardiac natriuretic hormones. Expression of preproET-1 (ppET-1) mRNA by cultured cardiac fibroblasts from neonatal rats was demonstrated by Northern blot analysis using cDNA for rat p
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10. Differentiation, Maturation, and Survival of Dendritic Cells by Osteopontin Regulation
Dendritic cells (DCs) are antigen-presenting cells with the ability to induce primary immune responses necessary in innate immunity and adaptive immunity. Osteopontin (OPN) is a secreted acidic phosphoprotein containing an arginine-glycine-aspartate sequence and has been suggested to play an important role in early cellular immune responses. The interaction
American Society for Microbiology.
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11. Effect of glucose/sulfonylurea interaction on release of insulin, glucagon, and somatostatin from isolated perfused rat pancreas.
The effect of a sulfonylurea, glibenclamide, on the release of insulin, glucagon, and somatostatin was studied in the isolated perfused rat pancreas. At glucose concentrations of 1.1 mM or less, the drug stimulated somatostatin release, whereas glucagon release, after 2-3 min of increase, was markedly inhibited. Insulin release was moderately stimulated, and
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12. In vivo inhibition of glucagon secretion by paracrine beta cell activity in man.
The close anatomical relationships betaeen pancreatic alpha and beta cells makes possible their interaction at a local (paracrine) level. To demonstrate this in vivo, we have compared the acute glucagon response to intravenous arginine in the basal state and after beta cell suppression by infusions of insulin. The plasma glucose concentration was maintained