Parthenolide
Mostrando 1-9 de 9 artigos, teses e dissertações.
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1. Trypanosoma Cruzi : estudos sobre o efeito do partenolídeo
a de Chagas é causada pelo protozoário Trypanosoma cruzi e é a doença endêmica de maior abrangência na América Latina, com aproximadamente 100 milhões de pessoas vivendo em áreas de risco. Assim como outras doenças causadas por protozoários parasitas, a única droga disponível para o tratamento dos doentes apresenta muitos efeitos colaterais, e n
Publicado em: 2007
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2. The solution and solid state stability and excipient compatibility of parthenolide in feverfew
The objectives of this research were to evaluate the stability of parthenolide in feverfew solution state and powdered feverfew (solid state), and explore the compatibility between commonly used excipients and parthenolide in feverfew. Feverfew extract solution was diluted with different pH buffers to study the solution stability of parthenolide in feverfew.
Springer-Verlag.
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3. Antileishmanial Activity of Parthenolide, a Sesquiterpene Lactone Isolated from Tanacetum parthenium
The in vitro activity of parthenolide against Leishmania amazonensis was investigated. Parthenolide is a sesquiterpene lactone purified from the hydroalcoholic extract of aerial parts of Tanacetum parthenium. This isolated compound was identified through spectral analyses by UV, infrared, 1H and 13C nuclear magnetic resonance imaging, DEPT (distortionless en
American Society for Microbiology.
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4. Modulation of DNA Methylation by a Sesquiterpene Lactone Parthenolide
Hypermethylation of 5′-cytosine-guanosine islands of tumor suppressor genes resulting in their silencing has been proposed to be a hallmark of various tumors. Modulation of DNA methylation with DNA methylation inhibitors has been shown to result in cancer cell differentiation or apoptosis and represents a novel strategy for chemotherapy. Currently, eff
American Society for Pharmacology and Experimental Therapeutics.
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5. CTGF Promotes Inflammatory Cell Infiltration of the Renal Interstitium by Activating NF-κB
Connective tissue growth factor (CTGF) is an important profibrotic factor in kidney diseases. Blockade of endogenous CTGF ameliorates experimental renal damage and inhibits synthesis of extracellular matrix in cultured renal cells. CTGF regulates several cellular responses, including adhesion, migration, proliferation, and synthesis of proinflammatory factor
American Society of Nephrology.
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6. Nuclear Factor-κB Regulates Estrogen Receptor-α Transcription in the Human Heart*
Estrogen receptor (ER)-mediated effects have been associated with the modulation of myocardial hypertrophy in animal models and in humans, but the regulation of ER expression in the human heart has not yet been analyzed. In various cell lines and tissues, multiple human estrogen receptor α (hERα) mRNA isoforms are transcribed from distinct promoters and di
American Society for Biochemistry and Molecular Biology.
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7. Requirement for NF-κB in Transcriptional Activation of Monocyte Chemotactic Protein 1 by Chlamydia pneumoniae in Human Endothelial Cells
Infection with Chlamydia pneumoniae, a causative agent of acute and chronic respiratory diseases, has recently been implicated as a potential risk factor in atherosclerosis. Atherosclerotic lesions are characterized by monocyte infiltration, which may be regulated by the chemokine monocyte chemotactic protein 1 (MCP-1). We have previously shown that C. pneum
American Society for Microbiology.
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8. Survival of Chlamydia pneumoniae-Infected Mono Mac 6 Cells Is Dependent on NF-κB Binding Activity
The respiratory tract pathogen Chlamydia pneumoniae has been associated with atherosclerosis. Monocytes are supposed to serve as a vehicle for systemic dissemination of intracellular C. pneumoniae from the lung to the artery vessel wall. We were therefore interested in pathogen-induced cellular events associated with NF-κB, a crucial transcription factor fo
American Society for Microbiology.
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9. NF-κB Activation during Rickettsia rickettsii Infection of Endothelial Cells Involves the Activation of Catalytic IκB Kinases IKKα and IKKβ and Phosphorylation-Proteolysis of the Inhibitor Protein IκBα
Rocky Mountain spotted fever, a systemic tick-borne illness caused by the obligate intracellular bacterium Rickettsia rickettsii, is associated with widespread infection of the vascular endothelium. R. rickettsii infection induces a biphasic pattern of the nuclear factor-κB (NF-κB) activation in cultured human endothelial cells (ECs), characterized by an e
American Society for Microbiology.