Partial Agonist
Mostrando 1-12 de 146 artigos, teses e dissertações.
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1. Editorial Comment: Increased risk of dementia among patients with overactive bladder treated with an anticholinergic medication compared to a beta-3 agonist: a population-based cohort study
ABSTRACT Hypothesis: Partial Nephrectomy is oncological safe in patients with pT3a RCC. Purpose: To compare the oncological and functional outcomes of patients with pT3a RCC scheduled for PN and RN. Materials and Methods: We retrospectively reviewed patients with pT3a N0 M0 RCC who underwent partial or radical nephrectomy from 2005 to 2016. Perioperative
Int. braz j urol.. Publicado em: 2021-08
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2. Analysis of psychiatrists’ prescription of opioid, benzodiazepine, and buprenorphine in Medicare Part D in the United States
Abstract Introduction The opioid epidemic is a severe problem in the world, especially in the United States, where prescription opioid overdose accounts for a quarter of drug overdose deaths. Objective To describe psychiatrists’ prescription of opioid, benzodiazepine, and buprenorphine in the United States. Methods We conducted a retrospective cross-
Trends Psychiatry Psychother.. Publicado em: 2020-03
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3. Corrigendum: Cognitive-behavioral therapy for treatment-resistant depression in adults and adolescents: a systematic review
Abstract Introduction The opioid epidemic is a severe problem in the world, especially in the United States, where prescription opioid overdose accounts for a quarter of drug overdose deaths. Objective To describe psychiatrists’ prescription of opioid, benzodiazepine, and buprenorphine in the United States. Methods We conducted a retrospective cross-
Trends Psychiatry Psychother.. Publicado em: 2020-03
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4. Nicotine receptor partial agonists for smoking cessation
BACKGROUND: Nicotine receptor partial agonists may help people to stop smoking by a combination of maintaining moderate levels of dopamine to counteract withdrawal symptoms (acting as an agonist) and reducing smoking satisfaction (acting as an antagonist). OBJECTIVES: The primary objective of this review is to assess the efficacy and tolerability of nicotine
Sao Paulo Med. J.. Publicado em: 2012
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5. Treatment of cutaneous tumors with topical 5% imiquimod cream
INTRODUCTION: There are various approaches to the treatment of cutaneous tumors; one of them is treatment with imiquimod, a synthetic toll-like receptor agonist with a low molecular weight that offers a topical, noninvasive, and non-surgical therapeutic option. The main objective of our study was to provide data on 89 patients who used a 5% imiquimod cream f
Clinics. Publicado em: 2009
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6. Tratamento neonatal com agonista 5-HT1A: repercussÃes sobre o desenvolvimento da atividade locomotora em ratos
Locomotion is an important function to living beings. Environmental changes that occur during the critical period of development can promote changes in the development of locomotor activity, bringing impairment for the individual. Works using automatic analysis of behavior are of great importance for the study of locomotion. Among the systems that can influe
Publicado em: 2009
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7. Investigação da atividade farmacológica de benzilideno-e acridinilideno-tiazolidinedionas e de isoflavonas nos receptores alfa, beta/delta e gama ativados por proliferadores peroxissomais
As tiazolidinedionas (TZDs) melhoram a sensibilidade insulínica e a homeostase da glicose em diversos modelos animais de obesidade e diabetes, e também em humanos. Esses benefícios são atribuídos, em grande parte, aos efeitos antiinflamatórios da ativação do receptor gama ativado por proliferadores peroxissomais (PPARg). No entanto, a utilização cl
Publicado em: 2008
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8. Papel dos receptores canabinóides em um modelo experimental de angiogênese inflamatória
Angiogenesis depends on a complex network of cells and mediators. The activation or blockade of cannabinoid receptors showed to be an interesting pharmacological strategy to attenuate the angiogenic and/or inflammatory response in many experimental models. Here we investigated how this strategy may interfere in inflammatory angiogenesis. Polyester-polyuretha
Publicado em: 2007
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9. Effects of Levetiracetam on pilocarpine-induced seizures in mice / Efeitos do levetiracetan no modelo de convulsões induzidas por pilorcarpina em camundongos
Levetiracetam (LEV) is a new antiepileptic drug effective as adjunctive therapy for partial seizures and in experimental models of seizures, including pilocarpine-induced seizures in rodents. Objectifying to clarify if anticonvulsant activity of LEV occurs near cholinergic muscarinic alterations, adult male mice received LEV injections before muscarinic agon
Publicado em: 2005
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10. Memantine binding to a superficial site on NMDA receptors contributes to partial trapping
Although many nervous system disorders are associated with N-methyl-d-aspartate (NMDA) receptor overactivation, pharmacological inhibition of NMDA receptors has typically demonstrated limited clinical value due to debilitating psychotomimetic side-effects. Memantine, however, induces far fewer behavioural side-effects than other NMDA receptor channel blocker
Blackwell Science Inc.
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11. Structural determinants for interaction of partial agonists with acetylcholine binding protein and neuronal α7 nicotinic acetylcholine receptor
The pentameric acetylcholine-binding protein (AChBP) is a soluble surrogate of the ligand binding domain of nicotinic acetylcholine receptors. Agonists bind within a nest of aromatic side chains contributed by loops C and F on opposing faces of each subunit interface. Crystal structures of Aplysia AChBP bound with the agonist anabaseine, two partial agonists
Nature Publishing Group.
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12. Comparison of the Antinociceptive and Antirewarding Profiles of Novel Bifunctional Nociceptin Receptor/μ-Opioid Receptor Ligands: Implications for Therapeutic Applications
The nociceptin receptor (NOPr), a member of the opioid receptor family, is a target for the treatment of pain and drug abuse. Nociceptin/orphanin FQ (N/OFQ), the endogenous peptide for NOPr, not only modulates opioid antinociception, but also blocks the rewarding effects of several abused drugs, such as morphine, cocaine, and amphetamine. We hypothesized tha
The American Society for Pharmacology and Experimental Therapeutics.