Pathological Angiogenesis
Mostrando 1-12 de 57 artigos, teses e dissertações.
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1. Tissue Factor Expression in Colorectal Adenocarcinoma: Association with Angiogenesis and Clinical and Pathological Aspects
Abstract Introduction Tissue factor (TF) expression has been described in various neoplasms and was correlated with angiogenesis and metastases. Objectives To describe TF expression in colorectal cancers, correlating it with microvessel density and clinical and pathological variables. Methods Immunohistochemistry was used to determine TF expression and
Journal of Coloproctology (Rio de Janeiro). Publicado em: 2022
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2. Eicosanoids and cancer
Eicosanoids are 20-carbon bioactive lipids derived from the metabolism of polyunsaturated fatty acids, which can modulate various biological processes including cell proliferation, adhesion and migration, angiogenesis, vascular permeability and inflammatory responses. In recent years, studies have shown the importance of eicosanoids in the control of physiol
Clinics. Publicado em: 09/08/2018
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3. Clinical Value of High Mobility Group Box 1 and the Receptor for Advanced Glycation Endproducts in Head and Neck Cancer: A Systematic Review
Abstract Introduction High mobility group box 1 is a versatile protein involved in gene transcription, extracellular signaling, and response to inflammation. Extracellularly, high mobility group box 1 binds to several receptors, notably the receptor for advanced glycation end-products. Expression of high mobility group box 1 and the receptor for advanced g
Int. Arch. Otorhinolaryngol.. Publicado em: 2016-12
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4. Immunohistochemical angiogenic biomarkers in hepatocellular carcinoma and cirrhosis: correlation with pathological features
OBJECTIVE To investigate immunohistochemical markers of angiogenesis and their association with pathological prognostic features in hepatocellular carcinoma and cirrhotic liver. METHODS Vascular endothelial growth factor, CD105, and cyclooxygenase-2 were immunohistochemically detected in 52 hepatocellular carcinoma tissue samples and 48 cirrhotic liver tis
Clinics. Publicado em: 2016-11
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5. Promoting inflammatory lymphangiogenesis by vascular endothelial growth factor-C (VEGF-C) aggravated intestinal inflammation in mice with experimental acute colitis
Angiogenesis and lymphangiogenesis are thought to play a role in the pathogenesis of inflammatory bowel diseases (IBD). However, it is not understood if inflammatory lymphangiogenesis is a pathological consequence or a productive attempt to resolve the inflammation. This study investigated the effect of lymphangiogenesis on intestinal inflammation by overexp
Braz J Med Biol Res. Publicado em: 08/04/2016
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6. Arthropod venom Hyaluronidases: biochemical properties and potential applications in medicine and biotechnology
AbstractHyaluronidases are enzymes that mainly degrade hyaluronan, the major glycosaminoglycan of the interstitial matrix. They are involved in several pathological and physiological activities including fertilization, wound healing, embryogenesis, angiogenesis, diffusion of toxins and drugs, metastasis, pneumonia, sepsis, bacteremia, meningitis, inflammatio
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 10/11/2015
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7. Composition and significance of glycosaminoglycans in the uterus and placenta of mammals
Glycosaminoglycans (GAGs) are heteropolysaccharides in mammalian tissue and consist of repeated disaccharide units with mono-sulfated or non-sulfated monosaccharides. GAGs are important components of the Extracellular Matrix (ECM) with several physiological roles, in the recognition, migration, adhesion, proliferation and differentiation processes. They are
Braz. arch. biol. technol.. Publicado em: 01/05/2015
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8. Putative role of ischemic postconditioning in a rat model of limb ischemia and reperfusion: involvement of hypoxia-inducible factor-1α expression
Hypoxia-inducible factor-1α (HIF-1α) is one of the most potent angiogenic growth factors. It improves angiogenesis and tissue perfusion in ischemic skeletal muscle. In the present study, we tested the hypothesis that ischemic postconditioning is effective for salvaging ischemic skeletal muscle resulting from limb ischemia-reperfusion injury, and that the m
Braz J Med Biol Res. Publicado em: 25/07/2014
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9. Vimentin and laminin are altered on cheek pouch microvessels of streptozotocin-induced diabetic hamsters
OBJECTIVE: Normal endothelial cells respond to shear stress by elongating and aligning in the direction of fluid flow. Hyperglycemia impairs this response and contributes to microvascular complications, which result in deleterious effects to the endothelium. This work aimed to evaluate cheek pouch microvessel morphological characteristics, reactivity, permea
Clinics. Publicado em: 2011
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10. Avaliação da expressão gênica da proteína 2 ligante de SH3 ativadora da GTPase de Ras (G3BP2), do fator da tecidual (TF) e da isoforma asHTF como possíveis marcadores prognósticos em carcinoma epidermóide de cabeça e pescoço / Evaluation of gene expression GTPase activating protein (SH3 domain) binding protein 2 (G3BP2), tissue factor (TF) and its isoform asHTF as possible prognostic markers in head and neck squamous cell carcinoma
GTPase activating protein (SH3 domain) binding protein 2 (G3BP2) seems to be involved in pathways important for cell survival as NF- B pathway. Tissue factor (TF) and its isoform asHTF appear to be involved in angiogenesis, proliferation and metastasis. Thus, the genes G3BP2, TF and asHTF seem possible prognostic factors in head and neck squamous cell carcin
Publicado em: 2009
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11. Thalidomide failed to inhibit angiogenesis and fibrosis in hepatic schistosomiasis of the mouse
The relationship between angiogenesis and fibrosis has been demonstrated in several pathological conditions, one of them being schistosomiasis. To observe whether suppression of angiogenesis would interfere with fibrosis, Thalidomide, an anti-angiogenesis drug, was administered during 30 consecutive days to mice with experimental schistosomiasis. Computerize
Memórias do Instituto Oswaldo Cruz. Publicado em: 30/10/2007
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12. Avaliação da expressão e dos níveis séricos do fator de crescimento do endotélio vascular (VEGF) e da densidade de microvasos em cães portadores de sarcomas de tecidos moles submetidos à excisão cirúrgica / Evaluation of the expression and serum level of the vascular endothelial growth factor (VEGF) and of the microvascular density in dogs with soft tissue sarcoma submitted to surgical excision
No indivíduo adulto, a angiogênese ocorre particularmente em situações patológicas como nos tumores em crescimento, no desenvolvimento de metástases e no processo de cicatrização, sendo o fator de crescimento do endotélio vascular (VEGF) o principal fator envolvido na angiogênese tumoral. Por essa razão, o presente estudo teve como objetivo avalia
Publicado em: 2007