Pathological Neovascularization
Mostrando 1-12 de 19 artigos, teses e dissertações.
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1. Study of vascular permeability and extracellular volume fraction in the differentiation of benign and malignant breast lesions / Estudo da permeabilidade vascular e volume extra-celular na diferenciação das lesões nodulares benignas e malignas da mama
INTRODUCTION: There has been a great development in the study of breast lesions with the use of contrast-enhanced magnetic resonance. However, several findings are common in malignant and in benign lesions turning their differentiation difficult. The objective of this research was to study the vascular permeability and the extracellular volume fraction (EVF)
Publicado em: 2009
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2. Amplificação dos genes que codificam a Endotelina - 1 e seus receptores em valvas mitrais reumáticas
Introduction: the study of the vasoconstrictor substance endothelin-1 and its receptors A and B, since its discovery in 1988, has grown gradually in the last years. This is due to their recognition as a critical element in the pathophysiology of many diseases, with emphasis on those from cardiovascular involvement. His role in vasorreactivity is already know
Publicado em: 2008
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3. Potential Role for ADAM15 in Pathological Neovascularization in Mice
ADAM15 (named for a disintegrin and metalloprotease 15, metargidin) is a membrane-anchored glycoprotein that has been implicated in cell-cell or cell-matrix interactions and in the proteolysis of molecules on the cell surface or extracellular matrix. To characterize the potential roles of ADAM15 during development and in adult mice, we analyzed its expressio
American Society for Microbiology.
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4. An anti-angiogenic state in mice and humans with retinal photoreceptor cell degeneration
Abnormal angiogenesis accompanies many pathological conditions including cancer, inflammation, and eye diseases. Proliferative retinopathy because of retinal neovascularization is a leading cause of blindness in developed countries. Another major cause of irreversible vision loss is retinitis pigmentosa, a group of diseases characterized by progressive photo
The National Academy of Sciences.
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5. Inducible nitric oxide synthase mediates the change from retinal to vitreal neovascularization in ischemic retinopathy
Intravitreal neovascular diseases are a major cause of blindness worldwide. It remains unclear why neovessels in many retinal diseases spread into the physiologically nonvascularized vitreous rather than into the ischemic retinal areas, where the angiogenic factors are released. Here we show that inducible nitric oxide synthase (iNOS) is expressed in the isc
American Society for Clinical Investigation.
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6. Preventing pathological regression of blood vessels
Oxygen administration to premature infants suppresses retinal VEGF expression and results in the catastrophic vessel loss associated with retinopathy of prematurity. A study investigating the development of the retinal vasculature in mice (see related article on pages 50–57) demonstrates that specific activation of VEGF receptor-1 by placental growth facto
American Society for Clinical Investigation.
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7. Involvement of integrins alpha v beta 3 and alpha v beta 5 in ocular neovascular diseases.
Angiogenesis underlies the majority of eye diseases that result in catastrophic loss of vision. Recent evidence has implicated the integrins alpha v beta 3 and alpha v beta 5 in the angiogenic process. We examined the expression of alpha v beta 3 and alpha v beta 5 in neovascular ocular tissue from patients with subretinal neovascularization from age-related
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8. Hypoxia-induced pathological angiogenesis mediates tumor cell dissemination, invasion, and metastasis in a zebrafish tumor model
Mechanisms underlying pathological angiogenesis in relation to hypoxia in tumor invasion and metastasis remain elusive. Here, we have developed a zebrafish tumor model that allows us to study the role of pathological angiogenesis under normoxia and hypoxia in arbitrating early events of the metastatic cascade at the single cell level. Under normoxia, implant
National Academy of Sciences.
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9. HLF/HIF-2α is a key factor in retinopathy of prematurity in association with erythropoietin
An HLF (HIF-1α-like factor)/HIF-2α-knockout mouse is embryonic lethal, preventing investigation of HLF function in adult mice. To investigate the role of HLF in adult pathological angiogenesis, we generated HLF-knockdown (HLFkd/kd) mice by inserting a neomycin gene sandwiched between two loxP sequences into exon 1 of the HLF gene. HLFkd/kd mice expressing
Oxford University Press.
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10. VEGF-A stimulates lymphangiogenesis and hemangiogenesis in inflammatory neovascularization via macrophage recruitment
Lymphangiogenesis, an important initial step in tumor metastasis and transplant sensitization, is mediated by the action of VEGF-C and -D on VEGFR3. In contrast, VEGF-A binds VEGFR1 and VEGFR2 and is an essential hemangiogenic factor. We re-evaluated the potential role of VEGF-A in lymphangiogenesis using a novel model in which both lymphangiogenesis and hem
American Society for Clinical Investigation.
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11. Autologous transplantation of genetically modified iris pigment epithelial cells: A promising concept for the treatment of age-related macular degeneration and other disorders of the eye
Age-related macular degeneration (ARMD) is the leading cause for visual impairment and blindness in the elder population. Laser photocoagulation, photodynamic therapy and excision of neovascular membranes have met with limited success. Submacular transplantation of autologous iris pigment epithelial (IPE) cells has been proposed to replace the damaged retina
The National Academy of Sciences.
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12. Immunotherapy for choroidal neovascularization in a laser-induced mouse model simulating exudative (wet) macular degeneration
Age-related macular degeneration (AMD) is the leading cause of blindness after age 55 in the industrialized world. Severe loss of central vision frequently occurs with the exudative (wet) form of AMD, as a result of the formation of a pathological choroidal neovasculature (CNV) that damages the macular region of the retina. We tested the effect of an immunot
The National Academy of Sciences.