Peptide Lipid Interaction
Mostrando 1-12 de 81 artigos, teses e dissertações.
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1. Interaction of antimicrobial peptide Plantaricin149a and four analogs with lipid bilayers and bacterial membranes
The amidated analog of Plantaricin149, an antimicrobial peptide from Lactobacillus plantarum NRIC 149, directly interacts with negatively charged liposomes and bacterial membranes, leading to their lysis. In this study, four Pln149-analogs were synthesized with different hydrophobic groups at their N-terminus with the goal of evaluating the effect of the mod
Braz. J. Microbiol.. Publicado em: 04/02/2014
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2. Efeito da carga dos lipídios na interação do BP100 em modelos de membrana / Charge effect of lipids in interaction of BP100 and model membranes
Antimicrobial peptides (AMPs) have been a promising alternative therapy to antibiotics. These molecules, consisting of less than 80 amino acids, with different structures and amino acids composition, have amphipathic character which gives them the ability to act on lipid bilayers. They act, by different mechanisms, over bacteria to mammal cells. The AMPs are
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 17/02/2012
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3. Plantaricin 149 and analogs: antimicrobial activity, structural studies and mechanisms of action. / Plantaricina 149 e análogos: atividade antimicrobiana, estudos estruturais e mecanismos de ação
Peptídeos antimicrobianos são vistos como alternativas promissoras a serem empregadas pela iindústria farmacêutica no controle de infecções causadas por microrganismos, como também na indústria alimentícia, onde podem desempenhar papéis como conservantes naturais de alimentos. Plantaricina149 é um membro deste grupo, sendo composto por 22 resíduo
Publicado em: 2010
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4. Sinalização intracelular e expressão de receptores mediados por LDL modificada e peptídeos da apolipoproteínaB-100 em monócitos/macrófagos humanos. / Intracellular signaling and receptor expression mediated by modified LDL and apolipoproteinB-100 peptides in human monocytes/macrophages.
The Low Density Lipoprotein (LDL) may undergo oxidative or enzymatic modifications, producing lipid or proteic compounds that interact with macrophages, contributing to inflammatory response in the atherosclerosis. Into the arterial intima, the macrophages interact with minimally modified LDL (LoxLDL) and with highly oxidized LDL (HoxLDL). Moreover, in the a
Publicado em: 2009
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5. Estudos estruturais de histatina-5 e seu análogo, TOAC0-histatina-5: interação com metais e sistemas biomiméticos / Structural studies of Histatin-5 and its analogue, TOAC0-Histatin-5: interaction with metals and biomimetic systems
The mechanism of action of histatin-5 (Hst-5), an antifungal antimicrobial peptide from human saliva is not completely clarified. Circular dichroism (CD), fluorescence, and electron paramagnetic resonance (EPR) were used to examine the conformational behavior of Hst-5 and its analogue containing the paramagnetic amino acid TOAC at the N-terminus (TOAC0-Hst-5
Publicado em: 2008
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6. Viral membrane fusion: is glycoprotein G of rhabdoviruses a representative of a new class of viral fusion proteins?
Enveloped viruses always gain entry into the cytoplasm by fusion of their lipid envelope with a cell membrane. Some enveloped viruses fuse directly with the host cell plasma membrane after virus binding to the cell receptor. Other enveloped viruses enter the cells by the endocytic pathway, and fusion depends on the acidification of the endosomal compartment.
Brazilian Journal of Medical and Biological Research. Publicado em: 2005-06
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7. Caracterização estrutural de peptídeos melanotrópicos e suas interações com agregados anfifílicos: um estudo por fluorescência e ressonância paramagnética eletrônica / Structural caracterization of melanotropic peptides and their interaction with amphilic aggregates: a study by fluorescence and electron spin resonance
Neste trabalho são apresentados vários estudos com o peptídeo melanotrópico catiônico alfa-MSH (hormônio estimulador de melanócito) e análogos biologicamente mais ativos. Foram utilizadas as técnicas de fluorescência estática e resolvida no tempo, e RPE (ressonância paramagnética eletrônica). Com fluorescência, foi monitorado o aminoácido Trp
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 31/01/2002
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8. A single-residue deletion alters the lipid selectivity of a K+ channel-associated peptide in the beta-conformation: spin label electron spin resonance studies.
Lipid-peptide interactions with the 27-residue peptide of sequence KLEALYILMVLGFFGFFTLGIMLSYIR reconstituted as beta-sheet assemblies in dimyristoylphosphatidylcholine bilayers have been studied by electron spin resonance (ESR) spectroscopy with spin-labeled lipids. The peptide corresponds to residues 42-68 of the IsK voltage-gated K+ channel protein and con
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9. Lipid II-Mediated Pore Formation by the Peptide Antibiotic Nisin: a Black Lipid Membrane Study
The antibiotic peptide nisin is the first known lantibiotic that uses a docking molecule within the bacterial cytoplasmic membrane for pore formation. Through specific interaction with the cell wall precursor lipid II, nisin forms defined pores which are stable for seconds and have pore diameters of 2 to 2.5 nm.
American Society for Microbiology.
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10. The interaction of a synthetic mitochondrial signal peptide with lipid membranes is independent of transbilayer potential.
We have used fluorescence measurements and assays of vesicle disruption (contents leakage) to monitor the interaction between lipid vesicles and a synthetic peptide corresponding to the N-terminal 27 amino acids of rat mitochondrial pre-ornithine carbamyltransferase (pOCT). This peptide and two fluorescent derivatives bind reversibly to vesicles composed of
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11. Interaction of small peptides with lipid bilayers.
Molecular dynamics simulations of the tripeptide Ala-Phe-Ala-O-tert-butyl interacting with dimyristoylphosphatidylcholine lipid bilayers have been carried out. The lipid and aqueous environments of the peptide, the alkyl chain order, and the lipid and peptide dynamics have been investigated with use of density profiles, radial distribution functions, alkyl c
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12. Membrane Interaction of Escherichia coli Hemolysin: Flotation and Insertion-Dependent Labeling by Phospholipid Vesicles
The 1,024-amino-acid acylated hemolysin of Escherichia coli subverts host cell functions and causes cell lysis. Both activities require insertion of the toxin into target mammalian cell membranes. To identify directly the principal toxin sequences dictating membrane binding and insertion, we assayed the lipid bilayer interaction of native protoxin, stably ac
American Society for Microbiology.