Peptidomics
Mostrando 1-10 de 10 artigos, teses e dissertações.
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1. O laser de baixa potência seria terapêutico para lesões causadas por acidentes ofídicos do gênero Bothrops?
Ainda não há evidências científicas em humanos, entretanto, em caráter experimental e de pesquisa, a laserterapia tem sido usada em lesões necróticas incapacitantes secundárias à picada por serpente na região amazônica, devido seu importante impacto em saúde pública pela retirada precoce do trabalhador na geração de renda. Assim, os benefí
Núcleo de Telessaúde Amazonas. Publicado em: 12/06/2023
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2. Characterization of Leiurus abdullahbayrami (Scorpiones: Buthidae) venom: peptide profile, cytotoxicity and antimicrobial activity
Background Scorpion venoms are rich bioactive peptide libraries that offer promising molecules that may lead to the discovery and development of new drugs. Leiurus abdullahbayrami produces one of the most potent venoms among Turkish scorpions that provokes severe symptoms in envenomated victims. Methods In the present study, the peptide profile of the v
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 02/12/2014
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3. Separomics applied to the proteomics and peptidomics of low-abundance proteins: choice of methods and challenges - a review
The enrichment and isolation of proteins are considered limiting steps in proteomic studies. Identification of proteins whose expression is transient, those that are of low-abundance, and of natural peptides not described in databases, is still a great challenge. Plant extracts are in general complex, and contaminants interfere with the identification of pro
Genetics and Molecular Biology. Publicado em: 2012
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4. Proteômica e peptidômica aplicadas ao estudo da defesa de plantas de tomate à injúria mecânica / Proteomics and peptidomics applied to study the defense of tomato plants of the mechanics injury
Plantas são expostas a estresses múltiplos, e suas respostas definirão sua capacidade de sobrevivência. Diferentes vias de resposta são induzidas pela ativação ou inibição de diversas proteínas, quando células de plantas são submetidas a alguma forma de estresse biótico ou abiótico. Estudos proteômicos estruturais e funcionais buscam avaliar o
Publicado em: 2008
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5. Combinatorial peptidomics: a generic approach for protein expression profiling
Traditional approaches to protein profiling were built around the concept of investigating one protein at a time and have long since reached their limits of throughput. Here we present a completely new approach for comprehensive compositional analysis of complex protein mixtures, capable of overcoming the deficiencies of current proteomics techniques. The Co
BioMed Central.
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6. Snapshot Peptidomics of the Regulated Secretory Pathway*
Neurons and endocrine cells have the regulated secretory pathway (RSP) in which precursor proteins undergo proteolytic processing by prohormone convertase (PC) 1/3 or 2 to generate bioactive peptides. Although motifs for PC-mediated processing have been described ((R/K)Xn(R/K) where n = 0, 2, 4, or 6), actual processing sites cannot be predicted from amino a
The American Society for Biochemistry and Molecular Biology.
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7. Striatal Alterations of Secretogranin-1, Somatostatin, Prodynorphin, and Cholecystokinin Peptides in an Experimental Mouse Model of Parkinson Disease*S⃞
The principal causative pathology of Parkinson disease is the progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta projecting to the striatum in the brain. The information regarding the expression of neuropeptides in parkinsonism is very limited. Here we have elucidated striatal neuropeptide mechanisms in experimental parkin
American Society for Biochemistry and Molecular Biology.
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8. Novel endogenous peptide agonists of cannabinoid receptors
Hemopressin (Hp), a 9-residue α-hemoglobin-derived peptide, was previously reported to function as a CB1 cannabinoid receptor antagonist (1). In this study, we report that mass spectrometry (MS) data from peptidomics analyses of mouse brain extracts identified N-terminally extended forms of Hp containing either three (RVD-Hpα) or two (VD-Hpα) additional a
The Federation of American Societies for Experimental Biology.
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9. Discovering New Bioactive Neuropeptides in the Striatum Secretome Using in Vivo Microdialysis and Versatile Proteomics S⃞
The striatum, a major component of the brain basal nuclei, is central for planning and executing voluntary movements and undergoes lesions in neurodegenerative disorders such as Huntington disease. To perform highly integrated tasks, the striatum relies on a complex network of communication within and between brain regions with a key role devoted to secreted
American Society for Biochemistry and Molecular Biology.
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10. Application of Label-free Quantitative Peptidomics for the Identification of Urinary Biomarkers of Kidney Chronic Allograft Dysfunction*
The advent of quantitative proteomics opens new opportunities in biomedical and clinical research. Although quantitative proteomics methods based on stable isotope labeling are in general preferred for biomolecular research, biomarker discovery is a case example of a biomedical problem that may be better addressed by using label-free MS techniques. As a proo
The American Society for Biochemistry and Molecular Biology.