Pericytes
Mostrando 1-12 de 71 artigos, teses e dissertações.
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1. Angiogenesis and experimental hepatic fibrosis
Angiogenesis is a basic change occurring during repair by granulation tissue. This process seems to precede fibrosis formation in most types of chronic liver disease. To examine its presence and significance in different types of hepatic insults, this paper sought to identify the presence, evolution and peculiarities of angiogenesis in the most common experi
Memórias do Instituto Oswaldo Cruz. Publicado em: 2010-08
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2. Angiogenesis and schistosomiasis
Angiogenesis has been recognised as a precursor of fibrosis in several pathologic conditions. Its participation has been demonstrated in schistosomiasis, both during periovular granuloma formation and in the genesis of schistosomal periportal fibrosis. Paradoxically, proliferation of new blood vessels, accompanied by production of vascular-endothelial growth
Memórias do Instituto Oswaldo Cruz. Publicado em: 2010-07
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3. Proporção volumétrica dos constituintes do corpo lúteo de Nelore
Volumetric proportions and nuclear diameter of the small and large luteinic cells of the corpus luteum (CL) were evaluated in ovaries of 17 Nelore cows and heifers, collected in slaughterhouse and classified into two groups: group I (GI, n=7), non-pregnant animals, and group II (GII, n=10), pregnant animals. The CL was reduced to small cuts (less than 3mm),
Arquivo Brasileiro de Medicina Veterinária e Zootecnia. Publicado em: 2006-10
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4. Morphologic spectrum, immunohistochemical characterization and prognosis of the canine haemangiopericytoma / Classificação morfológica, imunoistoquímica e prognóstica dos hemangiopericitomas caninos
Haemangiopericytomas CHP like Schwanomas are cutaneous neoplasms of mesenchymal origin, frequently appearing in dogs, unlike neurofibromas, which are rare on the species. There are cases reported that CHP originates from pericytes, or cells located around blood vessels. They are observed more in limbs such as tissues, they are well defined, big and firm. Hae
Publicado em: 2005
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5. Ultrastructural study of pericytes in the rat supraoptic nucleus.
Pericytes of the supraoptic nucleus of normal rats have been studied with the electron microscope. These cells are morphologically similar to those of pericytes in other parts of the nervous system. The pericytes and their cytoplasmic processes were surrounded by basal membrane. The nucleus contained large masses of heterochromatin. The cytoplasm, less dense
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6. What brings pericytes to tumor vessels?
Paracrine signaling via platelet-derived growth factor B (PDGFB), expressed by endothelial cells, and its receptor PDGFR-β, expressed by pericytes, plays a central role in blood vessel maturation. A new study reveals that it is not just the presence of PDGFB, but how it is presented to pericytes, that determines the quality of the endothelium-pericyte inter
American Society for Clinical Investigation.
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7. Endothelial and nonendothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors
Tumor-infiltrating blood vessels deviate morphologically and biochemically from normal vessels, raising the prospect of selective pharmacological targeting. Current antiangiogenic approaches focus mainly on endothelial cells, but recent data imply that targeting pericytes may provide additional benefits. Further development of these concepts will require dee
American Society for Clinical Investigation.
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8. An electron microscopic study of the pericytes of the developing capillaries in human fetal brain and muscle.
Capillaries of the developing cerebral cortex were examined by electron microscopy and compared with those developing in the superior rectus oculi muscle. The pericytes of cerebral vessels were found to be of very elaborate form and involved in complex 'peg and socket' relationships with endothelial cells. They were numerous and formed an almost complete inv
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9. Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall
Several platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF) family members display C-terminal protein motifs that confer retention of the secreted factors within the pericellular space. To address the role of PDGF-B retention in vivo, we deleted the retention motif by gene targeting in mice. This resulted in defective inve
Cold Spring Harbor Laboratory Press.
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10. Differential responsiveness to insulin of endothelial and support cells from micro- and macrovessels.
The pathologies of diabetic micro- and macroangiopathy are different, suggesting that diabetes affects these two types of vascular tissue in a dissimilar manner. We have compared insulin receptors and the effects of insulin on cultured endothelium from calf retinal capillaries and aorta, and the vascular supporting cells, retinal pericytes, and aortic smooth
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11. Expression of tissue factor procoagulant activity: regulation by cytosolic calcium.
Intact bovine fibroblasts, pericytes, and kidney cells manifested significantly less tissue factor procoagulant activity than their disrupted counterparts. Addition of calcium ionophore A23187 rapidly and reversibly enhanced the cell-surface expression of tissue factor in intact cells up to the level achieved by disruption. Inhibitors of calmodulin blocked t
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12. An activated form of transforming growth factor beta is produced by cocultures of endothelial cells and pericytes.
Using an in vitro coculture system to mimic the interactions between the cells of the vessel wall, we have previously shown that pericytes and smooth muscle cells (SMC) inhibit the growth of capillary endothelial cells (EC). We have undertaken studies to determine the mechanism of this inhibition. Using conditioned media and affinity-purified antibodies to t