Peripheral Insulin Resistance
Mostrando 1-12 de 85 artigos, teses e dissertações.
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1. Associations of circulating irisin with 24-h blood pressure, total and visceral fat, and metabolic parameters in young adult hypertensives
ABSTRACT Objective: Some experimental and clinical studies suggest a possible role of irisin in central and peripheral regulation of blood pressure. The purpose of the study was to assess the associations between serum irisin levels, total and visceral fat, metabolic parameters, and blood pressure pattern during 24-h monitoring (ABPM). Materials and method
Arch. Endocrinol. Metab.. Publicado em: 2021-04
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2. Insulin signaling in the whole spectrum of GH deficiency
ABSTRACT GH is one of the insulin counterregulatory hormones which acts in the opposite way to insulin, increasing the glucose production by the liver and kidneys and decreasing glucose uptake from peripheral tissues, thus being a hyperglycemic hormone. When in excess, as in acromegaly, it induces glucose intolerance and diabetes. As expected, patients with
Arch. Endocrinol. Metab.. Publicado em: 10/01/2020
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3. Role of microRNAs in the treatment of type 2 diabetes mellitus with Roux-en-Y gastric bypass
The aim of this study was to investigate the effect of Roux-en-Y gastric bypass (RYGB) on the peripheral blood microRNAs (miRNAs) of patients with type 2 diabetes mellitus (T2DM). miRNAs are small 20- to 22-nucleotide (nt) noncoding RNAs. They constitute a novel class of gene regulators that negatively regulate gene expression at the post-transcriptional lev
Braz J Med Biol Res. Publicado em: 02/03/2017
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4. Experimental model of glucocorticoid-induced insulin resistance
ABSTRACT PURPOSE: To evaluate metabolic effects in experimental model of glucocorticoid-induced insulin resistance. METHODS: Twenty Wistar male rats were randomly divided into two groups, which were treated with intraperitoneally injected dexamethasone 1mg/Kg/day for ten days consecutively (Group D; n=10) and placebo (Group C; n=10). The variables analyzed
Acta Cir. Bras.. Publicado em: 2016-10
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5. Mechanisms of endothelial dysfunction in obesity-associated hypertension
Obesity is strongly associated with high blood pressure, dyslipidemia, and type 2 diabetes. These conditions synergistically increase the risk of cardiovascular events. A number of central and peripheral abnormalities can explain the development or maintenance of high blood pressure in obesity. Of great interest is endothelial dysfunction, considered to be a
Brazilian Journal of Medical and Biological Research. Publicado em: 2012-05
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6. Efeitos da suplementação de zinco e do treinamento físico sobre o controle de peso e o metabolismo glicêmico em ratas ovariectomizadas
It is common to observe menopausal metabolic disorders that lead to weight gain and changes in glycemic control. Physical activity and zinc supplementation have been suggested as interventions to prevent weight gain and glucose metabolism disorders. Thus, this study aims to assess the effects of physical training and zinc supplementation on carbohydrate meta
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2012
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7. Dieta de cafeteria induz obesidade, resistência periférica a insulina, e reduz a secreção deste hormônio por ilhotas de ratas : restauração do processo secretório, mas não da sensibilidade à insulina durante a prenhez / Cafeteria diet induces obesity, peripheral insulin resistance, and reduces insulin secretion in isolated from rats : restoration of the secretory process but not of the insulin sensibility during pregnancy
A obesidade atingiu proporções alarmantes constituindo-se num fator de risco para o desenvolvimento de várias doenças. O aumento da resistência periférica à insulina acompanha esta patologia e a incapacidade da célula beta pancreática em suprir a maior necessidade por insulina leva ao desenvolvimento de intolerância à glicose, hiperglicemia e diab
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 31/03/2010
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8. Papel preventivo do exercício físico nas alterações observadas na via de sinalização insulínica induzidas pela Dexametasona
Peripheral insulin resistance is the major side effect after chronic dexamethasone (Dexa) treatment, which is widely used to control inflammatory diseases. On the other hand, exercise training increases insulin-dependent muscle glucose uptake and attenuates hyperglycemia and hyperinsulinemia induced by Dexa treatment. This study investigated whether exercise
Publicado em: 2010
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9. Dieta hiperlipídica poliinsaturada afeta as vias insulínica e inflamatória em hipotálamo de ratos/ / Hyperlipidic diet polyunsaturated affect the via insulinic and inflammatory in the hypothalamus of rats.
Insulin leads an anorexigenic response by acting on hypothalamic neurons. Studies suggest that resistance to its action is involved with diet-induced obesity (diet rich in saturated fatty acids) and its association with hypothalamic inflammation. However, the effects of polyunsaturated fatty acids on insulin and inflammatory signaling pathways are poorly und
Publicado em: 2010
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10. Fructose and cardiometabolic disorders: the controversy will, and must, continue
The present review updates the current knowledge on the question of whether high fructose consumption is harmful or not and details new findings which further pushes this old debate. Due to large differences in its metabolic handling when compared to glucose, fructose was indeed suggested to be beneficial for the diet of diabetic patients. However its growin
Clinics. Publicado em: 2010
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11. Relação entre a Síndrome Metabólica, teor de gordura intramiocelular e os níveis plasmáticos da Adiponectina: papel da Rosiglitazona / Relationship between the Metabolic Syndrome, intramyocellular fat and plasma Adiponectin: role of Rosiglitazone
Insulin resistance (IR) is associated with intramyocellular lipid (IMCL) content and low serum adiponectin (ADP) levels. ADP is also involved in muscle fat oxidation but the relationship between them is still controversial. We aimed to further explore the relationship between ADP and IMCL content in non-diabetic adults and the role of rosiglitazone (RSG) in
Publicado em: 2009
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12. Avaliação da função e plasticidade celuar de ilhotas pancreaticas em modelo de resistencia a insulina induzida por dexametosa em ratos / Analysis of dexamethasone treatment effcts on insulin secretion, molecular and biochemical parameters in submitted to protein restriction
Introduction and aims: Insulin binds to plasma membrane receptors leading to a variety of cellular responses. Malfunction in any of the insulin cell signalling pathways in target tissues may lead to several conditions and diseases, like hyperglycemia, insulin resistance and type 2 diabetes mellitus (T2DM). These effects may be experimentally reproduced using
Publicado em: 2008