Peripheral Neurotoxicity
Mostrando 1-12 de 25 artigos, teses e dissertações.
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1. Tratamento da sÃndrome da TensÃo PrÃ-Menstrual com vitamina B6: resposta terapÃutica e avaliaÃÃo de risco da neurotoxicidade perifÃrica
Premenstrual syndrome is a situation that reaches a great part of feminine population. According with ICD-10, history of few physical or behaviors symptoms that occur on cyclic form during luteal phase of menstrual cycle is requested and disappears within a few days since the beginning of menstruation. Despite many drugs to premenstrual tension treatment, a
Publicado em: 2003
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2. Analise dos elementos do tecido conjuntivo na resposta a injeção intrafascicular do anestesico ropivacaina em nervos ciaticos de coelhos
Persistent neurologic sequelae after central or peripheral nerve blockade with local anesthetics are rare, but in some cases a significant impact on the quality of life of the patients who suffer from such sequelae may occur. Experimental studies indicate that alI local anesthetics are potentially neurotoxin and the neurotoxicity paraIlels their anesthetic p
Publicado em: 2000
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3. Vinorelbine neurotoxicity: clinical and neurophysiological findings in 23 patients.
Vinorelbine (5'-noranhydrovinblastine) is a new semisynthetic antineoplastic vinca alkaloid which interfers with axonal transport, inducing spiralisation of axonal microtubules and resulting in peripheral neurotoxicity. A prospective detailed neurological and electrophysiological evaluation was performed in 23 patients treated with 25 mg vinorelbine a week.
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4. Neurophysiological studies on the relation between the structural properties and neurotoxicity of aliphatic hydrocarbon compounds in rats.
In order to determine the specific structural properties responsible for neurotoxic activity, the comparative neurotoxicity of n-hexane, methyl n-butyl ketone, 2,5-hexanedione, and their relatives was investigated in the peripheral nerves of rats. The maximum conduction velocity of motor and sensory fibres and the motor distal latency of the tail nerves of r
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5. Neurotoxicity of acrylamide and its analogues and effects of these analogues and other agents on acrylamide neuropathy.
N-Hydroxymethylacrylamide, N-methylacrylamide, and N,N-diethylacrylamide produce peripheral neuropathy in rats. Seven other compounds related to acrylamide do not produce neuropathy. Rats given one of the three neurotoxic compounds are more susceptible to acrylamide. A regime for testing acrylamide analogues for neuro-toxicity is suggested. DDT, phenobarbito
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6. A comparative study on the neurotoxicity of n-pentane, n-hexane, and n-heptane in the rat.
The neurotoxicity of n-pentane, n-hexane, and n-heptane have been studied in Wistar strain male rats after exposure to 3000 ppm of n-pentane, n-hexane, or n-heptane for 12 hours a day for 16 weeks. The nerve conduction velocity and the distal latency were measured before the beginning of the exposure and after exposure for four, eight, 12, and 16 weeks. The
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7. Familial deficiency of dihydropyrimidine dehydrogenase. Biochemical basis for familial pyrimidinemia and severe 5-fluorouracil-induced toxicity.
Severe neurotoxicity due to 5-fluorouracil (FUra) has previously been described in a patient with familial pyrimidinemia. We now report the biochemical basis for both the pyrimidinemia and neurotoxicity in a patient we have recently studied. After administration of a "test" dose of FUra (25 mg/m2, 600 microCi[6-3H]FUra by intravenous bolus) to a patient who
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8. Elemental mercury exposure: peripheral neurotoxicity.
Nerve conduction tests were performed on the right ulnar nerve of factory workers exposed to elemental mercury vapour. Time integrated urine mercury indices were used to measure the degree of exposure. Workers with prolonged distal latencies had significantly higher urine mercury concentrations when compared with those with normal latencies. Significant corr
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9. An experimental study on the combined effects of n-hexane and toluene on the peripheral nerve of the rat.
An electrophysiological study was undertaken to determine whether toluene affected the neurotoxicity of n-hexane. Separate groups of eight rats were exposed to 1000 ppm n-hexane, 1000 ppm toulene, 1000 ppm n-hexane plus 1000 ppm toluene, of fresh air in an exposure chamber for 12 hours a day for 16 weeks. The body weight, MCV, DL, MNCVs were measured before
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10. Correlation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity with blood-brain barrier monoamine oxidase activity.
Systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) causes parkinsonism in humans and subhuman primates, but not in rats and many other laboratory animals; mice are intermediate in their susceptibility. Since MPTP causes selective dopaminergic neurotoxicity when infused directly into rat substantia nigra, we hypothesized that syste
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11. Neurologic effects of alcoholism.
Alcoholism, a worldwide disorder, is the cause of a variety of neurologic disorders. In this article we discuss the cellular pathophysiology of ethanol addition and abuse as well as evidence supporting and refuting the role of inheritance in alcoholism. A genetic marker for alcoholism has not been identified, but neurophysiologic studies may be promising. So
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12. In vitro evidence that covalent crosslinking of neurofilaments occurs in gamma-diketone neuropathy.
We have postulated that the toxic neuropathies associated with neurofilament-filled axonal swellings have a common pathogenesis, the covalent crosslinking of neurofilaments during anterograde transport. The newly described gamma-diketone, 3,4-dimethyl-2,5-hexanedione (DMHD), is a more potent analogue of the toxic metabolite of n-hexane, 2,5-hexanedione. The