Permeation Enhancers
Mostrando 1-12 de 19 artigos, teses e dissertações.
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1. Influence of different formulation variables on the performance of transdermal drug delivery system containing tizanidine hydrochloride: in vitro and ex vivo evaluations
The present study was aimed at preparation of transdermal patches of tizanidine HCl, evaluation of the effect of polymers on in vitro release pattern of the drug, and the effect of permeation enhancers on the penetration of the drug through the rabbit skin. Various proportions of hydrophilic (HPMC) and hydrophobic (Eudragit L-100) polymers were used with PEG
Braz. J. Pharm. Sci.. Publicado em: 08/04/2019
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2. Formulation and in vitro evaluation of carbopol 934-based modified clotrimazole gel for topical application
ABSTRACT The aim of present study was to enhance topical permeation of clotrimazole gel preparation by using various permeability enhancers such as coconut oil, pistachio oil and sodium lauryl sulphate (SLS). Clotrimazole gel preparations were prepared and optimized by using three factor, five level central composite design. A second-order polynomial equatio
An. Acad. Bras. Ciênc.. Publicado em: 01/12/2016
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3. Evaluation of skin absorption of drugs from topical and transdermal formulations
ABSTRACT The skin barrier function has been attributed to the stratum corneum and represents a major challenge in clinical practice pertaining to cutaneous administration of drugs. Despite this, a large number of bioactive compounds have been successfully administered via cutaneous administration because of advances in the design of topical and transdermal f
Braz. J. Pharm. Sci.. Publicado em: 2016-09
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4. Synergistic effect of iontophoresis and chemical enhancers on transdermal permeation of tolterodine tartrate for the treatment of overactive bladder
PurposeThe objective of the study was to evaluate the synergistic transdermal permeation effect of chemical enhancers and iontophoresis technique on tolterodine tartrate (TT) transdermal gel and to evaluate its pharmacokinetic properties.Materials and MethodsTaguchi robust design was used for optimization of formulations. Skin permeation rates were evaluated
Int. braz j urol.. Publicado em: 2013-01
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5. Liberação de ropivacaína através da pele : aspectos biofarmacêuticos da incorporação de promotores de absorção e da encapsulação em nanopartículas / Ropivacaine released across the skin : biopharmaceuticals aspects of the incorporation of permeation enhancers and encapsulated in nanoparticles
Durante muito tempo, acreditou-se que a função primordial da pele era comportar-se como barreira a agentes químicos, físicos e microbiológicos. Hoje, entretanto, esta concepção mudou e verifica-se que a pele apresenta-se como uma estratégia para a administração cutânea de fármacos, possibilitando a utilização de formas farmacêuticas auto-admin
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 29/07/2011
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6. D-limonene influence in the cutaneous penetration enhancer for 5-aminolevulinic acid in photodynamic therapy of skin cancer: in vitro and in vivo skin permeation and retention studies. / A influência do D-limoneno como promotor de absorção de ácido 5-aminolevulínico para Terapia Fotodinâmica do câncer de pele: avaliação in vitro e in vivo da permeação e retenção cutâneas
BERTOLINI, WAGNER L. H. M. A influência do D-limoneno como promotor de absorção do ácido 5-aminolevulínico para Terapia Fotodinâmica do câncer de pele: avaliação in vitro e in vivo da permeação e retenção cutâneas. 2009 118f. Tese (Doutorado). Faculdade de Ciências Farmacêuticas de Ribeirão Preto Preto Universidade de São Paulo, Ribeirão P
Publicado em: 2009
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7. Efeitos de terpenos nas membranas de estrato córneo estudados por ressonância paramagnética eletrônica / Effects of terpenes on the stratum corneum membranes studied by electron paramagnetic resonance
The interaction of the skin penetration enhancers DL-menthol, -terpineol, 1,8-cineole and (+)-limonene with membranes of the uppermost skin layer, the stratum corneum (SC) and with multilamellar vesicles from 1,2-dipalmitoyl-sn-glycero-3-phosphaticylcholine (DPPC)is investigated by electron paramagnetic resonance (EPR) spectroscopy using spin-labeled
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 18/02/2008
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8. Development of creams containing kaurenoic acid and evaluation of in vivo topical antiinflamatory activity / Desenvolvimento de formas farmacêuticas semisólidas contendo ácido caurenóico e avaliação da atividade antiinflamatória in vivo
O ácido caurenóico (AC) é um diterpeno encontrado em diversas plantas como a Sphagneticola trilobata, Annona glabra, Vigueira robusta, Copaifera langsdorffi, Mikania glomerata e Mikania laevigata. O AC tem apresentado in vitro atividade tripanosomicida, antimicrobiana e antiinflamatória entre outras, sendo um composto com potencial aplicação no desenvo
Publicado em: 2007
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9. Avaliação da influência de tensoativos na pele de muda de cobra (Bothrops jararaca e Spilotis pullatus) por espectroscopia fatoacústica no infravermelho, calorimetria exploratória diferencial e espectroscopia Raman / Evaluation of the influence of surfactants on the stratum corneum of shed snake skin (Bothrops jararaca and Spilotis pullatus) by photoacoustic spectroscopy, differential scanning calorimetry and Raman spectroscopy
The influence of the surfactants sodium lauryl sulfate, cetyl trimethyl ammonium chloride and lauryl alcohol ethoxylate (12 moles ethylene oxide) was evaluated on the stratum corneum of shed snake skin (Bothrops jararaca and Spilotis pullatus) through the biophysical techniques PAS-FTIR, FT-Raman and DSC. The surfactants were used in solutions above and belo
Publicado em: 2004
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10. Transbuccal Delivery of 5-Fluorouracil: Permeation Enhancement and Pharmacokinetic Study
The purpose of this study was to determine the effect of permeation enhancers on the transbuccal delivery of 5-fluorouracil (FU). The effect of permeation enhancers on in vitro buccal permeability was assessed using sodium deoxycholate (SDC), sodium dodecyl sulphate (SDS), sodium tauroglycocholate (STGC), and oleic acid and their concentrations for absorptio
Springer US.
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11. Physical and chemical permeation enhancers in transdermal delivery of terbutaline sulphate
The efficacy of a magnetic field to act as a permeation enhancer was demonstrated. Because in vitro and in vivo performance of F1 and F2 were comparable, the substitution of chemical enhancers by magnetic field in transdermal delivery systems appears to be possible.
Springer-Verlag.
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12. The effect of pH and organic ester penetration enhancers on skin permeation kinetics of terbutaline sulfate from pseudolatex-type transdermal delivery systems through mouse and human cadaver skins
The purpose of this research was to prepare a pseudolatex transdermal delivery system for terbutaline sulfate and to evaluate the effect of pH and organic ester penetration enhancers on permeation kinetics of terbutaline sulfate through mice abdominal skin and human cadaver skin. An increase in the permeation flux by increasing pH was observed. The distribut
Springer-Verlag.