Peroxisome Proliferators
Mostrando 1-12 de 28 artigos, teses e dissertações.
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1. Characterization of PRLR and PPARGC1A genes in buffalo (Bubalus bubalis)
More than 40 million households in India depend at least partially on livestock production. Buffaloes are one of the major milk producers in India. The prolactin receptor (PRLR) gene and peroxisome proliferators activated receptor-γ coactivator 1-alpha (PPARGC1A) gene are reportedly associated with milk protein and milk fat yields in Bos taurus. In this stu
Genetics and Molecular Biology. Publicado em: 19/08/2011
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2. Mecanismos moleculares envolvidos na dominância negativa na síndrome de resistência ao hormônio tireoideano : I. genes regulados negativamente pelo receptor de hormônio tireoideano; II. genes regulados pelos receptores ativos por proliferadores de peroxissoma
A Síndrome de Resistência ao Hormônio Tireoideano (SRHT) é uma patologia caracterizada pela resposta reduzida dos tecidos-alvo ao hormônio tireoideano (HT). Ocorre comumente devido a mutações em um alelo do gene do receptor do hormônio tireoideano β (TRβ) que codifica para um TR mutante, o qual inibe a função do TRβ wt, fenômeno con
Publicado em: 2010
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3. Atividade agonista do extrato de Tabebuia heptaphylla sobre os receptores proliferadores peroxissomais alfa (PPAR a), beta/delta (PPAR ß/d) e gama (PPAR y)
Over recent decades, the prevalence of metabolism disorders such as metabolic syndrome, obesity and diabetes have, increased drastically, becoming a global epidemic. Therefore, new effective therapies to avoid the advance these diseases will have a great impact in the public health. Peroxisome proliferators-activated receptors (PPARs) have used as a pharmaco
Publicado em: 2008
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4. Rosiglitazona, agonista do PPAR-y "Peroxisome Proliferator-Activated Receptor-y" reverte a nefrotoxicidade induzida pelo tenofovir-DF / The peroxisome proliferator-activated receptor-y agonist rosiglitazone reverses tenofovir-induced nephrotoxicity
Objective: To characterize the mechanisms of tenofovir disoproxil fumarate (TDF)- induced nephrotoxicity and the protective effects of rosiglitazone (RSG), a peroxisome proliferator-activated receptor-y agonist. Methods: Rats were treated for 30 days with one of two TDF doses (50 or 300 mg/kg of food), to which RSG (92 mg/kg of food) was added for the last 1
Publicado em: 2008
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5. Increased expression of MMP-9, PPAR a and Chlamydophila pneumoniae e Mycoplasma pneumoniae antigens in atherosclerostic aortic fragments with aneurysms / Expressão aumentada dos antígenos de MMP-9 PPAR, Chlamydophila pneumoniae e Mycoplasma pneumoniae em fragmentos ateroscleróticos de aorta com aneurisma
Introdução: Aneurisma de aorta é considerado uma doença inflamatória crônica, mas ainda é controverso se está relacionado a aterosclerose aos agentes infecciosos. Antígenos de Chlamydophila pneumoniae (CP) e Mycoplasma pneumoniae (MP) foram encontrados em grande quantidade nas placas instáveis que usualmente estão associadas a remodelamento positi
Publicado em: 2008
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6. Chalcona como modelo de estudo no receptor ativado por proliferador peroxissomal (PPAR)
Peroxisome proliferators-activated receptors (PPAR) are genes regulators of important physiological processes, such as glucose homeostasis and inflammatory processes. Therefore, the development of ligants which behave as agonist for PPAR, have special interest in the research of the treatment of illnesses such as diabetes mellitus, dislypidemia and arteriosc
Publicado em: 2008
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7. The mouse peroxisome proliferator activated receptor recognizes a response element in the 5' flanking sequence of the rat acyl CoA oxidase gene.
Peroxisome proliferators are a diverse group of chemicals, including several hypolipidaemic drugs, that activate a nuclear hormone receptor termed the peroxisome proliferator activated receptor (PPAR). The peroxisomal enzyme acyl CoA oxidase (ACO) is the most widely used marker of peroxisome proliferator action. We have examined the 5' flanking region of the
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8. Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators.
To gain insight into the function of peroxisome proliferator-activated receptor (PPAR) isoforms in rodents, we disrupted the ligand-binding domain of the alpha isoform of mouse PPAR (mPPAR alpha) by homologous recombination. Mice homozygous for the mutation lack expression of mPPAR alpha protein and yet are viable and fertile and exhibit no detectable gross
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9. Peroxisome proliferators induce mouse liver stearoyl-CoA desaturase 1 gene expression.
Peroxisome proliferators induce stearoyl-CoA desaturase activity (EC 1.14.99.5) in liver [Kawashima, Y., Hanioka, N., Matsumura, M. & Kozuka, H. (1983) Biochim. Biophys. Acta 752, 259-264]. We analyzed the changes in stearoyl-CoA desaturase 1 (SCD1) mRNA to further define the molecular mechanism for the induction of stearoyl-CoA desaturase by peroxisome prol
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10. Transcription regulation of peroxisomal fatty acyl-CoA oxidase and enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase in rat liver by peroxisome proliferators.
The structurally diverse peroxisome proliferators ciprofibrate, clofibrate, and bis(2-ethylhexyl) phthalate [(EtHx)2 greater than Pht] increase the activities of hepatic catalase and peroxisomal fatty acid beta-oxidation enzymes in conjunction with profound proliferation of peroxisomes in hepatocytes. In order to delineate the level at which these enzymes ar
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11. Transformation of mammalian cells by overexpressing H2O2-generating peroxisomal fatty acyl-CoA oxidase.
Peroxisome proliferators induce qualitatively predictable pleiotropic responses, including development of hepatocellular carcinomas in rats and mice despite the inability of these compounds to interact with and damage DNA directly. In view of the nongenotoxic nature of peroxisome proliferators, it has been postulated that hepatocarcinogenesis by this class o
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12. In Vivo Regulation of Hepatitis B Virus Replication by Peroxisome Proliferators†
The role of the peroxisome proliferator-activated receptor α (PPARα) in regulating hepatitis B virus (HBV) transcription and replication in vivo was investigated in an HBV transgenic mouse model. Treatment of HBV transgenic mice with the peroxisome proliferators Wy-14,643 and clofibric acid resulted in a less than twofold increase in HBV transcription rate
American Society for Microbiology.