Pertussis Vaccine
Mostrando 1-12 de 175 artigos, teses e dissertações.
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1. Situação epidemiológica da coqueluche no Distrito Federal entre 2007 e 2016
Resumo A vigilância da coqueluche intensificou-se no Brasil com o aumento de casos a partir de 2012. Em 2015, a quantidade de notificações no Distrito Federal diminuiu, possivelmente devido à introdução da vacina adsorvida difteria, tétano e pertussis acelular para gestantes em novembro de 2014 no país. Trata-se de estudo descritivo, baseado na revis
Rev. Bioét.. Publicado em: 10/01/2020
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2. Low tetanus-diphtheria-acellular pertussis (Tdap) vaccine coverage among healthcare workers in a quaternary university hospital in São Paulo, Brazil: need for continuous surveillance and implementation of active strategies
Abstract Introduction: Vaccination with tetanus-diphtheria-acellular pertussis (Tdap) has been recommended for healthcare workers (HCWs) by Brazilian Ministry of Health since November 2014. Objective: To describe the strategies implemented to improve Tdap uptake, cumulative vaccine coverage after each intervention, variables associated to Tdap vaccination,
Braz J Infect Dis. Publicado em: 24/10/2019
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3. Short-term and long-term antibody response by mice after immunization against Neisseria meningitidis B or diphtheria toxoid
Serogroup B Neisseria meningitidis (MenB) is a major cause of invasive disease in early childhood worldwide. The only MenB vaccine available in Brazil was produced in Cuba and has shown unsatisfactory efficacy when used to immunize millions of children in Brazil. In the present study, we compared the specific functional antibody responses evoked by the Cuban
Braz J Med Biol Res. Publicado em: 01/02/2013
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4. Comparative analysis of the intracerebral mouse protection test and serological method for potency assays of pertussis component in DTP vaccine
The aim of this study was to compare the PSPT standardized in-house as an alternative to MPT for potency assays of pertussis component. Statistical analyses have showed similar pertussis potency values when PSPT was compared to MPT. Significant correlation between the potency results obtained by in vivo and in vitro assays was also been observed. Results by
Brazilian Journal of Microbiology. Publicado em: 2012-06
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5. Destruction of immunobiologicals and their disposal
The guidelines of the Brazilian National Health System (SUS) state that the municipal authorities are responsible for the vaccination of the population. The present study examined the types of immunobiologicals, amounts and reasons for their destruction and disposal by the Municipal Health Secretariat in the city of Bauru, São Paulo state, Brazil, between 2
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 2011
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6. Clonagem, expressão e avaliação da imunogenicidade e do potencial adjuvante induzidos pela proteína "heat-shock" Cpn60 da Bordetella pertussis. / Molecular cloning, expression and evaluation of immunogenicity and adjuvant potential induced from the heat-shock protein Cpn60 from Bordetella pertussis.
The Cpn60 protein is a member of a group of higly conserved proteins linked to essencial cell functions. The Cpn60 was cloned, expressed and its immune response has been evaluated. BALB\c mice were immunized with 5 or 10 µg of the recombinant protein (Cpn60r) alone or mixed with DPT vaccine without aluminum hidroxyde (NADPT). The DPT vaccine from Instituto
Publicado em: 2010
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7. Development of a therapeutic vaccine against HPV16 / Desenvolvimento de vacina terapêutica contra HPV16
Cervical cancer is the second most common cancer among women worldwide. Most cases (83%) occur in developing countries, where they are found in relatively advanced stages and, consequently, the median survival is about 49% after five years. Therefore, an effective vaccine against HPV infections can lead to control of cancer of the cervix. Although preventabl
Publicado em: 2010
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8. Pattern of functional antibody activity against Haemophilus influenzae type b (Hib) in infants immunized with diphtheria-tetanus-pertussis/Hib Brazilian combination vaccine
We evaluated the functional activity of Haemophilus influenzae B (Hib) antibodies elicited in a group of infants immunized with the diphtheria-tetanus-pertussis vaccine combined with an Hib vaccine produced totally in Brazil after technological transfer of Hib vaccine production from Glaxo SmithKline, Belgium. Blood samples from immunized infants (N = 985) w
Brazilian Journal of Medical and Biological Research. Publicado em: 06/11/2009
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9. Evaluation of adjuvants in new triple bacterial vaccine formulation. / Avaliação de adjuvantes em novas formulações de vacina tríplice bacteriana.
The whole cell pertussis vaccines present some reactogenicity and the acellular, less reactogenic, have prohibitive use due to its high cost. Instituto Butantan developed a less reactogenic whole cell pertussis vaccine (Plow), with low lipopolysaccharide content and an acellular vaccine (Pa), by simple and economic methodology. These preparations, combined t
Publicado em: 2009
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10. Immunogenicity, reactogenicity and consistency of production of a Brazilian combined vaccine against diphtheria, tetanus, pertussis and Haemophilus influenzae type b
A randomized, double-blinded study evaluating the immunogenicity, safety and consistency of production of a combined diphtheria-tetanus-pertussis-Haemophilus influenzae type b vaccine entirely produced in Brazil by Bio-Manguinhos and Instituto Butantan (DTP/Hib-BM) was undertaken. The reference vaccine had the same DTP vaccine but the Hib component was produ
Memórias do Instituto Oswaldo Cruz. Publicado em: 2008-11
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11. Whooping cough - theoretical evaluation of new vaccination strategies in São Paulo - Brazil / Avaliação de novas estratégias vacinais contra a coqueluche no município de São Paulo
Background: Whooping cough is a respiratory tract infection caused by Bordetella pertussis and characterized by paroxysmal cough that usually causes complications for infants, including death, and for people with chronic respiratory diseases. Immunity against pertussis after infection or vaccination is not everlasting. Despite of high childhood immunization
Publicado em: 2008
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12. Humoral and cellular response in infants vaccinated with whole-cell pertussis or modified cellular pertussis with low / Resposta humoral e celular de lactentes vacinados com pertussis celular total ou modificada pela extração de lipopolissacarideo
A associação temporal de eventos adversos de variada gravidade à imunização com pertussis celular total (DTP) tem estimulado o desenvolvimento de vacinas antipertussis menos reatogênicas. Este ensaio clínico fase I visou à avaliação da imunogenicidade da vacina pertussis celular modificada pela extração do lipopolissacarídeo (DTPm) em comparaç�
Publicado em: 2008