Pharmaceutical Excipients
Mostrando 1-12 de 49 artigos, teses e dissertações.
-
1. Compatibility by a Nonisothermal Kinetic Study of Azathioprine Associated with Usual Excipients in the Product Quality Review Process
Azathioprine is an immunosuppressive drug for several inflammatory disorders. Due to its clinical relevance, to explore the solid-state properties for excipient compatibility in the product quality review process is essential. Fourier transform infrared spectroscopy, powder X-ray diffraction and thermal analysis (thermogravimetry/derivative thermogravimetry
J. Braz. Chem. Soc.. Publicado em: 2021-03
-
2. Novel PEG 4000 derivatives and its use in controlled release of drug indomethacin
The insertion of functional groups in polymer compounds may facilitate their interaction with different drugs. PEG polymers are widely used for their low melting point, low toxicity, drug compatibility, and hydrophilicity. They are used as pharmaceutical excipients for the formulation of conventional or modified released drugs and are designed to be upgraded
Quím. Nova. Publicado em: 2020-06
-
3. Preformulation of a liquid dosage formulation of captopril for pediatric use: drug-excipient compatibility and stability studies
Currently, medications used in children are typically modified from pharmaceutical dosage forms designed for adults. Captopril is widely adapted to liquid formulations for use in hospitals. Its stability in the aqueous medium is reduced since it undergoes oxidation producing captopril disulfide (its main metabolite). The aim of this formulation study was to
Braz. J. Pharm. Sci.. Publicado em: 20/12/2019
-
4. Desenvolvimento e caracterização de membranas de quitosana / Cissus Verticillata (L.) Nicolson & C.E. Jarvis
RESUMO Os polímeros, devido às suas diversas aplicações e funcionalidades, estão entre os excipientes mais utilizados para a obtenção de formas farmacêuticas, ganhando destaque a quitosana. O objetivo deste trabalho foi desenvolver e avaliar comparativamente membranas de quitosana com diferentes concentrações da espécie vegetal Cissus verticillata
Matéria (Rio J.). Publicado em: 16/09/2019
-
5. Development and validation of a quantification method for α-humulene and trans-caryophyllene in Cordia verbenacea by high performance liquid chromatography
ABSTRACT Acheflan® herbal medicine is the first medicine developed and produced in Brazil using Cordia verbenacea DC., Boraginaceae, essential oil as a constituent. C. verbenacea has anti-inflammatory properties, which have been directly related to α-humulene and trans-caryophyllene. Currently, the quantification of α-humulene and trans-caryophyllene in C
Rev. bras. farmacogn.. Publicado em: 27/05/2019
-
6. Pharmaceutical development of tablets containing a spray-dried optimized extract from Lippia origanoides H. B. K.: influence of excipients and toxicological assessment
ABSTRACT Lippia origanoides is a honey shrub which has showed hypotensive potential assessed by in vivo studies. The aim of this work is the development of a pharmaceutical formulation composed by an optimized extract obtained from aerial parts of L. origanoides. The quantification of the naringenin marker in the dry extract and tablets developed was perform
Braz. J. Pharm. Sci.. Publicado em: 26/07/2018
-
7. Solubility and dissolution studies of tibolone polymorphs
ABSTRACT Different solid forms of an active pharmaceutical ingredient can have distinct chemical and physical characteristics. In this work, we studied the solubility and dissolution properties of the described tibolone polymorphic forms (I and II). Both forms were successively recrystallized and characterized by powder X-ray diffraction and attenuated total
Braz. J. Pharm. Sci.. Publicado em: 05/03/2018
-
8. Xuezhikang reduced arterial stiffness in patients with essential hypertension: a preliminary study
This study aimed to test the effects of xuezhikang, a cholestin extract that contains statin-like components, on arterial stiffness in patients with essential hypertension. One hundred hypertensive patients from the Chinese PLA General Hospital were randomly allocated to receive xuezhikang (1200 mg/day, orally) or placebo (same capsules containing only pharm
Braz J Med Biol Res. Publicado em: 31/08/2017
-
9. The Use of Near Infrared Spectroscopy and Multivariate Calibration for Determining the Active Principle of Olanzapine in a Pharmaceutical Formulation
The aim of this study was to quantitatively determine the olanzapine in a pharmaceutical formulation for assessing the potentiality of near infrared spectroscopy (NIR) combined with partial least squares (PLS) regression. The method was developed with samples based on a commercial formulation containing olanzapine and seven excipients. Laboratory and commerc
J. Braz. Chem. Soc.. Publicado em: 2017-05
-
10. Development and validation of alternative methods by non-aqueous acid-base titration and derivative ultraviolet spectrophotometry for quantification of sildenafil in raw material and tablets
Sildenafil citrate (SILC) is a potent phosphodiesterase-5 inhibitor used for erectile dysfunction and pulmonary hypertension. This study shows two simple, fast and alternative analytical methods for SILC determination by non-aqueous titration and by derivative ultraviolet spectrophotometry (DUS) in active pharmaceutical ingredient and/or dosage forms. The qu
Braz. J. Pharm. Sci.. Publicado em: 20/04/2017
-
11. DEVELOPMENT OF A SECOND TYPE ELECTRODE BASED ON THE SILVER/SILVER IBUPROFENATE PAIR FOR IBUPROFEN QUANTIFICATION IN PHARMACEUTICAL SAMPLES
Ibuprofen is a widely used pharmaceutical because of its therapeutic properties; it is considered a safe medicament, thus it does not require medical prescription to be sold. However, in order to ensure consumer's health it is indispensable that the pharmaceutical industry relies on analytic methods for its quantification. Potentiometry has proven to be a su
Quím. Nova. Publicado em: 2017-01
-
12. In vitro evaluation of cutaneous penetration of acyclovir from semisolid commercial formulations and relation with its effective antiviral concentration
ABSTRACT The evaluation of drug permeation/penetration of semisolid formulations into animal skin can be useful to supplement the pharmaceutical equivalence. This paper describes the in vitro assessment of acyclovir (ACV) into porcine skin from commercial formulations with etermination of drug concentration in different layers of cutaneous tissue to correlat
Braz. J. Pharm. Sci.. Publicado em: 2016-09