Phorbol 12 Myristate 13 Acetate
Mostrando 1-12 de 659 artigos, teses e dissertações.
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1. Antinociceptive effect of semi-purified petroleum ether partition of Muntingia calabura leaves
ABSTRACT Muntingia calabura L., Muntingiaceae, is a medicinal plant for various pain-related diseases. The aims of the present study were to determine the antinociceptive profile and to elucidate the possible mechanisms of antinociception of petroleum ether partition obtained from crude methanol extract of M. calabura leaves using various animal models. The
Rev. bras. farmacogn.. Publicado em: 2016-08
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2. Hydroxychloroquine decreases Th17-related cytokines in systemic lupus erythematosus and rheumatoid arthritis patients
OBJECTIVES: Hydroxychloroquine is an antimalarial agent that has been used in systemic lupus erythematosus and rheumatoid arthritis treatment for many years. Recently, novel mechanisms of action have been proposed, thereby broadening the therapeutic perspective of this medication. The purpose of this study was to evaluate the immunomodulatory activity of hy
Clinics. Publicado em: 2013-06
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3. Modulation of ROS production in human leukocytes by ganglioside micelles
Recent studies have reported that exogenous gangliosides, the sialic acid-containing glycosphingolipids, are able to modulate many cellular functions. We examined the effect of micelles of mono- and trisialoganglioside GM1 and GT1b on the production of reactive oxygen species by stimulated human polymorphonuclear neutrophils using different spectroscopic met
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-10
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4. Estudo da modulação de funções efetoras de neutrófilos humanos por derivados cumarínicos: avaliação do efeito biológico sobre a produção de espécies reativas de oxigênio e a desgranulação / Study of modulation of human neutrophil effector functions by coumarin derivatives: evaluation of biological effect on reactive oxygen species production and degranulation
Neutrophils are phagocytic cells from the innate immune system with highly developed mechanisms for intracellular digestion of pathogens, immune complexes and cell debris, which are mainly mediated by reactive oxygen species (EROs) and proteolytic enzymes. However, massive neutrophil activation lead to release of large amounts of enzymes and EROs to the extr
Publicado em: 2009
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5. Papel da proteína quinase C (PKC) na modulação da isoforma 1 do permutador Na+ - H+ (NHE1), em células MDCK. / Role of PKC on exchanger isoform 1 (NHE1), modulation in MDCK cells.
O presente trabalho visa contribuir para o esclarecimento da seqüência de eventos intracelulares produzidos pelas PKCs a e e, na modulação do pHi, via NHE1. Os estudos foram realizados em células MDCK e as medidas de pHi efetuadas por microscopia de fluorescência. A expressão das PKCs a e e, bem como do NHE1 foi investigada por western blot, utilizand
Publicado em: 2008
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6. Effect of sphingosine and phorbol-12-myristate-13-acetate on the growth and dimethylsulfoxide-induced differentiation in the insect trypanosomatid Herpetomonas samuelpessoai
We investigated the effect of two modulators of protein kinase C, sphingosine and phorbol-12-myristate-13-acetate (PMA), on the growth and dimethylsulfoxide (DMSO)-induced differentiation in Herpetomonas samuelpessoai. Sphingosine did not stimulate the transformation of undifferentiated-promastigotes in differentiated-paramastigotes. PMA alone or in associat
Memórias do Instituto Oswaldo Cruz. Publicado em: 14/06/2007
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7. Mecanismos anti-proliferativos disparados por FGF2 e éster de forbol em células de camundongos tranformadas por Ras / Anti-proliferative mechanisms induced by FGF2 and phorbol ester in murine cell lines transformed by Ras
Mutações com ganho de função do proto-oncogene Ras se encontram entre umas das mais freqüentes modificações em cânceres humanos, além disso, tumores com esses caracterísitcas possuem, em geral, mau prognóstico. O objetivo inicial desta tese foi estudar novos mecanismos anti-proliferativos disparados por dois agentesmitogênicos, FGF2 ("Fibroblast
Publicado em: 2007
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8. Influence of bovine enzootic leukosis on respiratory burst activity of leukocytes / Influência da leucose enzoótica bovina na atividade oxidativa de leucócitos
Different leukocyte populations play key roles on the elimination of foreign antigens through phagocytosis and killing by oxygen-independent and -dependent (respiratory burst) mechanisms. Assuming that Enzootic Bovine Leukosis virus (BLV), that causes a chronic disease, and affects, mainly, lymphoid tissues, alters bovine circulating leukocyte subpopulations
Publicado em: 2007
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9. Indole ring oxidation by activated leukocytes prevents the production of hypochlorous acid
Hypochlorous acid (HOCl) released by activated leukocytes has been implicated in the tissue damage that characterizes chronic inflammatory diseases. In this investigation, 14 indole derivatives, including metabolites such as melatonin, tryptophan and indole-3-acetic acid, were screened for their ability to inhibit the generation of this endogenous oxidant by
Brazilian Journal of Medical and Biological Research. Publicado em: 2005-11
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10. Effect of therapeutic plasma concentrations of non-steroidal anti-inflammatory drugs on the production of reactive oxygen species by activated rat neutrophils
The release of reactive oxygen specie (ROS) by activated neutrophil is involved in both the antimicrobial and deleterious effects in chronic inflammation. The objective of the present investigation was to determine the effect of therapeutic plasma concentrations of non-steroidal anti-inflammatory drugs (NSAIDs) on the production of ROS by stimulated rat neut
Brazilian Journal of Medical and Biological Research. Publicado em: 2005-04
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11. The effect of medium composition on interleukin-2 production by murine EL-4 thymoma cells
Due to the role of interleukin-2 (IL-2) in the mediation of immune response, this cytokine has been used in the treatment of some types of cancer and infectious diseases. However, relatively high levels of this cytokine are required to achieve significant activity. The aim of this work was to study a culture medium composition designed to increase the produc
Brazilian Journal of Chemical Engineering. Publicado em: 2004-06
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12. Cytotoxicity of chlorhexidine digluconate to murine macrophages and its effect on hydrogen peroxide and nitric oxide induction
Chlorhexidine, even at low concentrations, is toxic for a variety of eukaryotic cells; however, its effects on host immune cells are not well known. We evaluated in vitro chlorhexidine-induced cytotoxicity and its effects on reactive oxygen/nitrogen intermediate induction by murine peritoneal macrophages. Thioglycollate-induced cells were obtained from Swiss
Brazilian Journal of Medical and Biological Research. Publicado em: 2004-02