Phosphate Buffer
Mostrando 1-12 de 842 artigos, teses e dissertações.
-
1. SOCIOLOGIA SAGRADA
Benzbromarone (BZB) is a drug that has diuretic activity and is used in the gout treatment. Its therapeutic efficiency is decreased by its low water solubility (11.8 mg L-1) and highly hydrophobic aspect (logP 2.7), which are responsible for affecting its intestinal absorption and bioavailability. BZB inclusion complex (IC) aims at increasing the drug solubi
Sociol. Antropol.. Publicado em: 2020-08
-
2. Preparation and Characterization of the β-Cyclodextrin Inclusion Complex with Benzbromarone
Benzbromarone (BZB) is a drug that has diuretic activity and is used in the gout treatment. Its therapeutic efficiency is decreased by its low water solubility (11.8 mg L-1) and highly hydrophobic aspect (logP 2.7), which are responsible for affecting its intestinal absorption and bioavailability. BZB inclusion complex (IC) aims at increasing the drug solubi
J. Braz. Chem. Soc.. Publicado em: 2020-08
-
3. SPECIATION ANALYSIS OF ARSENIC IN RICE USING HIGH PERFORMANCE LIQUID CHROMATOGRAPHY COUPLED WITH HYDRIDE GENERATION ATOMIC FLUORESCENCE SPECTROMETRY (HPLC-HG-AFS)
The aim of this work was to develop a method using high performance liquid chromatography coupled with hydride generation atomic fluorescence spectrometry (HPLC-HG-AFS) for the determination and speciation analysis of the inorganic and organic species of arsenic found most often in rice samples: As(V), As(III), monomethylarsonic acid (MMA), and dimethylarsin
Quím. Nova. Publicado em: 2020-06
-
4. Chitosan-Sodium Alginate Polyelectrolyte Complex Coating Pluronic® F127 Nanoparticles Loaded with Citronella Essential Oil
Pluronic® F127 nanoparticles were loaded with citronella essential oil (CEO) and then covered with chitosan-sodium alginate polyelectrolyte complex (PEC). The system was characterized according to size, zeta potential and stability over time. Dynamic light scattering (DLS) in different proportions of water/ethanol as a dispersive medium was important in con
J. Braz. Chem. Soc.. Publicado em: 2020-04
-
5. Simultaneous determination of anti-diabetic drugs
A novel reverse phase, isocratic HPLC method is described to separate five anti-diabetic drugs i.e., glimepiride, metformin, sitagliptin, rosiglitazone and pioglitazone. Nucleosil C18 analytical column was used as stationary phase, while mobile phase consisted of acetonitrile:phosphate buffer: methanol (40/40/20, v/v) pH 2.0. Effluent was monitored at a flow
Braz. J. Pharm. Sci.. Publicado em: 20/12/2019
-
6. Enhancing Antitumor Efficacy of Cisplatin Low Dose by EDTA in Ehrlich Ascetic Carcinoma Bearing Mice
Abstract In a recent study, the treatment of different human cancer cell lines in vitro with ethylene diamine tetra-acetic acid (EDTA) showed a promising anticancer activity which could be a novel promising approach for cancer treatment. The aim of this study is to address the ability of EDTA to enhance the antitumor efficacy of the low dose of cisplatin (Ci
Braz. arch. biol. technol.. Publicado em: 20/12/2019
-
7. Evaluation of recombinant human interferon beta 1b by liquid chromatography methods and bioassay
Recombinant human interferon beta 1b (rhIFNβ-1b) is clinically used to treat multiple sclerosis. A reversed-phase liquid chromatography (RP-LC) method was carried out on a Jupiter C4 column (250 mm × 4.6 mm i.d.). The mobile phase A consisted of 0.1% trifluoroacetic acid (TFA) in water, and the mobile phase B was acetonitrile with 0.1% TFA run at a flow ra
Braz. J. Pharm. Sci.. Publicado em: 24/10/2019
-
8. Solid dispersion-based pellet for colon delivery of tacrolimus through time- and pH-dependent layer coating: preparation, in vitro and in vivo studies
The intent of the present investigation is to develop and evaluate colon-specific coated tacrolimus solid dispersion pellet (SDP) that retards drug release in the stomach and small intestine but progressively releases in the colon. Tacrolimus-SDP was prepared by extrusion-spheronization technology and optimized by the micromeritic properties including flowab
Braz. J. Pharm. Sci.. Publicado em: 24/10/2019
-
9. Development of a generic method for the determination of proton-pump inhibitors by capillary zoneelectrophoresis
A generic capillary zone electrophoresis method was developed for the analysis of four proton pump inhibitors: omeprazole, pantoprazole, lansoprazole and rabeprazole. During preliminary analysis screening of phosphate buffers at different pH levels was performed, in order to determine the optimum pH domain suitable for the simultaneous determination of all s
Braz. J. Pharm. Sci.. Publicado em: 30/09/2019
-
10. POLYPHENOL OXIDASE AND PEROXIDASE ENZYME ASSAYS IN SWEET POTATO CULTIVARS HARVESTED AT DIFFERENT TIMES
RESUMO Ensaios enzimáticos são baseados em metodologias descritas na literatura. Entretanto, a cinética enzimática deve ser ajustada para resultados mais confiáveis. Objetivou-se ajustar os ensaios testando diferentes volumes de extrato de polifenoloxidase (PPO) e peroxidase (POD) e tempos de reação em cultivares de batata-doce colhidas em diferentes
Rev. Caatinga. Publicado em: 18/07/2019
-
11. Determination of Gemifloxacin in human plasma by high performance liquid chromatography using Ultra Violet detector and its application to a bioequivalence study
A liquid chromatography method was developed and validated for the determination of gemifloxacin in human plasma using chloramphenicol as internal standard to achieve lower quantification limit. Acetonitrile was used to precipitated and extracted analyte and internal standard from plasma by Protein Precipitation. Analysis was performed isocratically on C18 c
Braz. J. Pharm. Sci.. Publicado em: 08/04/2019
-
12. Preparation and characterization of cefuroxime axetil solid dispersions using poloxamer 188
The main objective of the present work was to enhance the solubility and dissolution rate of poorly water-soluble drug cefuroxime axetil (CA) by formulating it into solid dispersions (SDs) with water soluble carrier poloxamer 188. Different methods were employed to prepare the dispersion, such as: Solvent method (SM), Kneading method (KM), Melt evaporation m
Braz. J. Pharm. Sci.. Publicado em: 08/04/2019