Phosphatidylserine
Mostrando 1-12 de 445 artigos, teses e dissertações.
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1. Nitro-Heterocyclic compounds induce apoptosis-like effects in Leishmania (L). amazonensis promastigotes
Abstract Background: Three drugs - pentavalent antimonials, amphotericin B and pentamidine - are currently used for leishmaniasis treatment. They are administered for long periods, only parenterally, and have high cardiac, renal and hepatic toxicities. Therefore, the investigation of new compounds is required. Nitro-heterocyclic derivatives have been used a
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 11/03/2019
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2. Fabrication of Multiple Layered Scaffolds with Controlled Porous Micro-Architecture
A multi-layer scaffold that incorporates bioglass, phosphatidylserine and steroidal saponins loaded collagen microparticles was prepared in this study. Combinatorial processing techniques involving porogen leaching protocol and freeze-drying were used. Drug distribution and microstructure could be controlled mainly by the concentrations of drug-loaded collag
Mat. Res.. Publicado em: 16/01/2017
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3. Antimonial drugs entrapped into phosphatidylserine liposomes: physicochemical evaluation and antileishmanial activity
Abstract: INTRODUCTION: Leishmaniasis is a disease caused by the protozoan Leishmania that resides mainly in mononuclear phagocytic system tissues. Pentavalent antimonials are the main treatment option, although these drugs have toxic side effects and high resistance rates. A potentially alternative and more effective therapeutic strategy is to use liposom
Rev. Soc. Bras. Med. Trop.. Publicado em: 2016-04
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4. Microporous Nano-hydroxyapatite/collagen/phosphatidylserine Scaffolds Embedding Collagen Microparticles for Controlled Drug Delivery in Bone Tissue Engineering
AbstractScaffolds featuring spatiotemporal control of drug release is highly desirable for bone tissue regeneration. The objective of this study was to construct a scaffold with gradient porosity and drug distribution and evaluate the effect of scaffold structure on drug release kinetics and cell bioactivity. Nano-hydroxyapatite/collagen/phosphatidylserine s
Mat. Res.. Publicado em: 2015-10
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5. Leishmania amazonensis exhibits phosphatidylserine-dependent procoagulant activity, a process that is counteracted by sandfly saliva
Leishmania parasites expose phosphatidylserine (PS) on their surface, a process that has been associated with regulation of host's immune responses. In this study we demonstrate that PS exposure by metacyclic promastigotes of Leishmania amazonensis favours blood coagulation. L. amazonensis accelerates in vitro coagulation of human plasma. In addition, L. am
Mem. Inst. Oswaldo Cruz. Publicado em: 2013-09
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6. Apoptotic-like activity of staurosporine in axenic cultures of Trypanosoma evansi
Trypanosoma evansi is a blood protozoan parasite of the genus Trypanosoma which is responsible for surra (Trypanosomosis) in domestic and wild animals. This study addressed apoptotic-like features in Trypanosoma evansi in vitro. The mechanism of parasite death was investigated using staurosporine as an inducing agent. We evaluated its effects through several
Revista do Instituto de Medicina Tropical de São Paulo. Publicado em: 2012-04
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7. Miltefosine induces programmed cell death in Leishmania amazonensis promastigotes
In the current study, we evaluated the mechanism of action of miltefosine, which is the first effective and safe oral treatment for visceral leishmaniasis, in Leishmania amazonensis promastigotes. Miltefosine induced a process of programmed cell death, which was determined by the externalization of phosphatidylserine, the incorporation of propidium iodide, c
Memórias do Instituto Oswaldo Cruz. Publicado em: 2011-06
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8. Desenvolvimento e farmacocinética de antimônio encapsulado em lipossomas de fosfatidilserina utilizando radioisótopos em leishmaniose experimental / Development and pharmacokinetic of antimony encapsulated in liposomes of phosphatidylserine using radioisotopes in experimental leishmaniasis
Leishmaniases are a complex of parasitic diseases caused by intramacrophage protozoa of the genus Leishmania, and is fatal if left untreated. Pentavalent antimonials, though toxic and their mechanism of action being unclear, remain the first-line drugs for treatment. Effective therapy could be achieved by delivering antileishmanial drugs to these sites of in
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 19/03/2010
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9. Characterization of the effect of an aminophospholipid (APLT) from Leishmania (Leishmania) amazonensis on phosphatidylserine exposure. / Caracterização do efeito de uma translocase de aminofosfolipídio (APLT) de Leishmania (Leishmania) amazonensis na exposição de fosfatidilserina.
O mecanismo responsável pela exposição da fosfatidilserina (PS) nas membranas celulares não está bem definido. Uma atividade dependente de ATP está envolvida, provavelmente uma ATPase tipo-P. ATPases tipo P são uma família de proteínas transmembranares envolvidas no transporte de metais, íons e fosfolipídios através da membrana plasmática. As P4
Publicado em: 2010
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10. Dengue-2 infection and the induction of apoptosis in human primary monocytes
Monocytes/macrophages are important targets for dengue virus (DENV) replication; they induce inflammatory mediators and are sources of viral dissemination in the initial phase of the disease. Apoptosis is an active process of cellular destruction genetically regulated, in which a complex enzymatic pathway is activated and may be trigged by many viral infecti
Memórias do Instituto Oswaldo Cruz. Publicado em: 2009-12
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11. Geração de espécies reativas por exossomos plaquetários: um possível novo mecanismo de disfunção vascular na sepse / Generation of reactive oxygen species by platelet-derived exosomes: a possible novel mechanism of vascular dysfunction in sepsis
Sepsis, the bodys response to infection, is associated with high mortality rates. Why a protective mechanism turns into a deadly clinical picture is a matter of debate, and goes largely unexplained. In previous work we demonstrated that plateled derived exosomes are found in the plasma of septic patients with septic shock and can induce endothelial and vascu
Publicado em: 2009
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12. EVALUATION OF RADIOLABELING OF ANNEXIN A5 WITH TECHNETIUM-99m: INFLUENCE OF THE LABELING METHODS ON PHYSICO-CHEMICAL AND BIOLOGICAL PROPERTIES OF THE COMPOUNDS / Avaliação da radiomarcação da anexina A5 com Tecnécio-99m: influência do método de marcação nas propriedades físicos-químicas e biológicas do composto
Annexin A5 (ANXA5) is an intracellular human protein of 36 kDa with high affinity for membrane-bound phosphatidylserine that is selectively exposed on the surface of cells undergoing apoptosis. Apoptosis is important in normal physiology and innumerous pathologic states. Clinical applications for ANXA5 imaging are being developed in oncology, organ transplan
Publicado em: 2009