Phospholipase D2
Mostrando 1-12 de 324 artigos, teses e dissertações.
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1. Inflammation in Cardiovascular Disease: From Basic Concepts to Clinical Application
Abstract Although low-density lipoprotein cholesterol is central to the development and progression of atherosclerosis, the role of inflammation in the atherosclerotic process is becoming better understood and appreciated. Chronic inflammatory conditions such as rheumatoid arthritis, lupus, psoriasis, HIV infection, and inflammatory bowel disease have all be
Int. J. Cardiovasc. Sci.. Publicado em: 2020-10
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2. Effect of phospholipase A2 inhibitors during infection caused by Leishmania (Leishmania) amazonensis
Abstract Background: Lipid metabolites play an important role in parasite differentiation and virulence. Studies have revealed that Leishmania sp. uses prostaglandins to evade innate barriers, thus enabling the parasites to survive inside immune cells. Despite the role of the enzyme Phospholipase A2 (PLA2) in prostaglandins production, few studies have inve
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 21/09/2018
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3. Effects of baicalin on inflammatory reaction, oxidative stress and PKDl and NF-kB protein expressions in rats with severe acute pancreatitis
Abstract Purpose: To investigate the effects of baicalin on inflammatory reaction, oxidative stress and protein kinase D1 (PKD1) and nuclear factor-kappa B (NF-κB) protein expressions in severe acute pancreatitis (SAP) rats. Methods: Sixty rats were divided into sham operation, model, and low-, medium- and high-dose baicalin group. SAP model was establis
Acta Cir. Bras.. Publicado em: 2018-07
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4. Biochemical characterization of a phospholipase A2 homologue from the venom of the social wasp Polybia occidentalis
Abstract Background: Wasp venoms constitute a molecular reservoir of new pharmacological substances such as peptides and proteins, biological property holders, many of which are yet to be identified. Exploring these sources may lead to the discovery of molecules hitherto unknown. This study describes, for the first time in hymenopteran venoms, the identific
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 26/03/2018
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5. In vitro activity of phospholipase A 2 and of peptides from Crotalus durissus terrificus venom against amastigote and promastigote forms of Leishmania (L.) infantum chagasi
Abstract Background American visceral leishmaniasis is caused by the intracellular parasiteLeishmania (L.) infantum chagasi, and transmitted by the sand fly Lutzomyia longipalpis. Since treatment is based on classical chemotherapeutics with significant side effects, the search for new drugs remains the greatest global challenge. Thus, this in vitro study a
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 22/12/2015
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6. Sulfated polysaccharide extracted of the green algae Caulerpa racemosa increase the enzymatic activity and paw edema induced by sPLA2 from Crotalus durissus terrificus venom
Sulfated polysaccharides derived from seaweed have shown great potential for use in the development of new drugs. In this study, we observed that a low-molecular-weight sulfated polysaccharide from Caulerpa racemosa, termed CrSP, could interact with secretory phospholipase A2 (sPLA2) isolated from Crotalus durissus terrificus venom. When native sPLA2 (14 kDa
Rev. bras. farmacogn.. Publicado em: 02/08/2013
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7. Estudo das ações neurotóxica, miotóxica e pró-inflamatória da PLA2 BrTX-I, isolada do veneno de Bothrops roedingeri (Jérgon da Costa) : caracterização bioquímica e farmacológica in vivo e ex vivo / Study of neurotoxic, myotoxic and proinflammatory actions of BrTX-I PLA2, isolated from Bothrops roedingeri (Jergon Coast) : biochemical and pharmacological characterization in vivo and ex vivo
Uma grande variedade de toxinas provenientes de venenos animais tem sido largamente utilizada no estudo de mecanismos de ação e processos fisiológicos, sendo consideradas valiosas ferramentas moleculares. As serpentes peçonhentas expressam no veneno diversas proteínas muito estudadas e utilizadas clinicamente, apresentando diferentes graus de variabilid
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 09/10/2012
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8. Caracterização estrutural e funcional da fosfolipase A IND. 2 BtTX-II, purificada do veneno da serpente Bothriopsis taeniata / Structural and functional characterization of the phospholipase A IND. 2 BTTX-II, purified of the Bothriopsis taeniata snake venom
Uma nova miotoxina fosfolipase A2 (BtTX-II) foi purificada a partir do veneno total de Bothriopsis taeniata através de dois passos cromatográficos, envolvendo inicialmente cromatografia de exclusão molecular, seguida de HPLC de fase reversa. BtTX-II foi caracterizada bioquimicamente através de eletroforese em gel de poliacrilamida (SDS-PAGE) mostrando um
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 30/03/2012
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9. Uso contínuo de antipsicóticos modula fosfolipase A2 e glicogênico sintase quinase-3 beta em plaquetas de pacientes com esquizofrenia / Antipsychotics prolonged use modulates phospholipase A2 and glycogen synthase kinase-3 beta in platelets from patients with schizophrenia
Duas enzimas têm-se destacado como possíveis marcadores biológicos periféricos na esquizofrenia: a fosfolipase A2 (PLA2) e a glicogênio sintase quinase-3 beta (GSK-3B). Essas moléculas exercem importante influência na arquitetura e plasticidade celulares, na regulação de vias metabólicas comuns (metabolismo de fosfolípides e via Wnt), em fatores d
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 09/03/2012
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10. Synergistic haemolytic activity and its correlation to phospholipase D productivity by Corynebacteruim pseudotuberculosis Egyptian isolates from sheep and buffaloes
Fourteen isolates of Corynebacteruim pseudotuberculosis of them 7 were isolated from sheep with Caseous Lymphadenitis "biotype 1" and 7 isolated from buffaloes with Oedematous Skin Disease "biotype 2". All isolates were identified by standard microbiological techniques and by polymerase chain reaction targeting, 16S rRNA and phospholipase D genes. Synergisti
Brazilian Journal of Microbiology. Publicado em: 2012-06
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11. Mechanism involved in the anti-inflammatory effect of Spiranthera odoratissima (Manacá)
Acetic acid-induced writhing, hot-plate, carrageenan-induced pleurisy, formalin-induced pain, croton oil-induced ear edema, vascular permeability tests and phospholipase A2 activity assay were used to study the analgesic and/or anti-inflammatory activity of the hydromethanolic fraction of ethanolic extract from Spiranthera odoratissima A. St.-Hil., Rutaceae,
Revista Brasileira de Farmacognosia. Publicado em: 26/08/2011
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12. Avaliação da glicosilação não enzimática (glicação) sobre a fosfolipases A2 secretórias pró-inflamatórias isoladas de venenos de serpentes / Evaluation of non enzymatic glycosylation (glycation) on phospholipase A2 secretory pro-inflammatory isolated from snake venoms
O objetivo deste trabalho foi avaliar o efeito de glicações sobre a PLA2 secretórias isoladas do veneno das serpentes Crotalus durissus collilineatus e Bothrops jararacussu. A técnica de MALDI-TOF foi usado para comprovar a glicação dos carboidratos nas PLA2: a PLA2 de Cdcolli apresentou glicação a 6 moléculas de D-Glicose e de 5 moléculas de D-Lac
Publicado em: 2011