Photocarcinogenesis
Mostrando 1-10 de 10 artigos, teses e dissertações.
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1. Photoprotection in adolescents: what they know and how they behave
Abstract: Background: The greatest sun exposure occurs until adolescence and this is the only factor involved in photocarcinogenesis subject to modification with photoprotection. Objective: The objective of this study was to evaluate the habits and knowledge of adolescents regarding photoprotection. Method: Cross-sectional study that included 512 students
An. Bras. Dermatol.. Publicado em: 2018-02
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2. Análise do fenômeno da imunotolerância na fotocarcinogênese em lábio / Analysis of the immunotolerance phenomenon of in the lip photocarcinogenesis
Ultraviolet radiation (UV) is the main cause of non-melanoma skin cancer and induces biological effects that promote photocarcinogenesis by causing mutations directly on DNA. However, there seems to be an indirect effect, which induces immunosuppession. The physiological phenomenon of immune tolerance, which is responsible for the prevention of autoimmune di
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 07/12/2011
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3. Proteínas e polimorfismos de genes de reparo de DNA na fotocarcinogênese em lábio / Proteins and polymorfism of DNA repair genes in lip photocarcinogenesis
O carcinoma epidermóide de lábio (CEL) e a queilite actínica (QA) são condições que atingem o vermelhão do lábio e são causadas pela exposição crônica e excessiva à radiação ultravioleta (UV) do sol. A absorção da radiação UV produz dois tipos predominantes de danos ao DNA, os dímeros de pirimidina-ciclobutanos (CPD) e os fotoprodutos 6-4
Publicado em: 2009
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4. The presence of proteins hMLH1 and hMSH6 of DNA mismatch repair system in actinic cheilitis and squamous cell carcinoma of the lip / "A presença das proteínas hMLH1 e hMSH6 do sistema de reparo do mau pareamento do DNA em queilites actínicas e carcinomas epidermóides de lábio"
Actinic cheilitis (AC) results from chronic and excessive exposure of the lips to the ultraviolet radiation in sunlight. AC is recognized as a potentially malignant condition and it is estimated that 10% to 20% will become lip squamous cell carcinoma (LSCC). It has been suggested that virtually every LSCC was initially AC. It is well known that solar radiati
Publicado em: 2006
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5. Topical DNA oligonucleotide therapy reduces UV-induced mutations and photocarcinogenesis in hairless mice
UV-induced DNA damage gives rise to mutations and skin cancer. We have previously reported that treatment of skin cells in vitro with thymidine dinucleotide (pTT) activates p53 and increases the ability of cells to repair subsequent UV-induced DNA damage by enhancing endogenous DNA repair capacity. Here we show that topical pTT pretreatment enhances the rate
National Academy of Sciences.
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6. Photocarcinogenesis and inhibition of intercellular adhesion molecule 1 expression in cells of DNA-repair-defective individuals
Cells from patients with xeroderma pigmentosum complementation group D (XP-D) and most patients with trichothiodystrophy (TTD) are deficient in excision repair of ultraviolet (UV) radiation-induced DNA damage. Although in both syndromes this defect is based on mutations in the same gene, XPD, only XP-D, not TTD, individuals have an increased risk of skin can
The National Academy of Sciences of the USA.
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7. A role for ultraviolet A in solar mutagenesis.
It is well established that exposure to solar UVB (290-320 nm) gives rise to mutations in oncogenes and tumor suppressor genes that initiate the molecular cascade toward skin cancer. Although UVA (320-400 nm) has also been implicated in multistage photocarcinogenesis, its potential contribution to sunlight mutagenesis remains poorly characterized. We have de
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8. Enzyme plus light therapy to repair DNA damage in ultraviolet-B-irradiated human skin
Ultraviolet-B (UVB) (290–320 nm) radiation-induced cyclobutane pyrimidine dimers within the DNA of epidermal cells are detrimental to human health by causing mutations and immunosuppressive effects that presumably contribute to photocarcinogenesis. Conventional photoprotection by sunscreens is exclusively prophylactic in nature and of no value once DNA dam
The National Academy of Sciences.
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9. Clues to epidermal cancer proneness revealed by reconstruction of DNA repair-deficient xeroderma pigmentosum skin in vitro
Sun exposure has been clearly implicated in premature skin aging and neoplastic development. These features are exacerbated in patients with xeroderma pigmentosum (XP), a hereditary disease, the biochemical hallmark of which is a severe deficiency in the nucleotide excision repair of UV-induced DNA lesions. To develop an organotypic model of DNA repair defic
The National Academy of Sciences.
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10. Polypodium leucotomos Extract Decreases UV-Induced Cox-2 Expression and Inflammation, Enhances DNA Repair, and Decreases Mutagenesis in Hairless Mice
UV-irradiated skin and UV-induced tumors overexpress the inducible isoform of cyclooxygenase-2 (Cox-2), and Cox-2 inhibition reduces photocarcinogenesis. To evaluate photoprotective effects of Polypodium leucotomos extract (PL), hairless Xpc+/− mice were fed for 10 days with PL (300 mg/kg) or vehicle then UV-irradiated, once. By 24 hours, UV-induced Cox-2
American Society for Investigative Pathology.